Could an implant replace daily eye drops for glaucoma?

NCT ID NCT04499248

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an implant called AGN-193408 SR that is placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 100 participants will receive the implant, and some will also get standard eye drops for comparison. The goal is to see if the implant is safe and effective at reducing eye pressure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AGN-193408 SR implant
What this could lead to: If successful, this implant could provide a longer-lasting way to lower eye pressure, reducing the need for daily eye drops.
What could go wrong: This is an early-phase trial with only 100 participants, so results may not apply to everyone. Risks include side effects from the implant procedure or the drug itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ocular hypertension open-angle glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OCULAR HYPERTENSION OPEN-ANGLE GLAUCOMA

Contacts and locations

Locations

Advanced Research, LLC /ID# 276987

Deerfield Beach, Florida, 33064-1346, United States
Advancing Vision Research /ID# 236683

Smyrna, Tennessee, 37167, United States
Asheville Eye Associates /ID# 234963

Asheville, North Carolina, 28803, United States
Brandon Eye Associates - Brandon /ID# 276600

Brandon, Florida, 33511, United States
Coastal Research Associates /ID# 234649

Roswell, Georgia, 30076, United States
Connecticut Eye Consultants P.C. /ID# 235862

Danbury, Connecticut, 06810, United States
Drs Fine Hoffman & Sims LLC /ID# 235919

Eugene, Oregon, 97401, United States
Duplicate_Shimane University Hospital /ID# 238641

Izumo-shi, Shimane, 693-8501, Japan
East Florida Eye Institute /ID# 235762

Stuart, Florida, 34994, United States
Eye Specialty Group /ID# 252201

Memphis, Tennessee, 38120, United States
Fraser Eye Care Center /ID# 267100

Fraser, Michigan, 48026, United States
Global Research Management /ID# 241699

Glendale, California, 91204-2500, United States
Hayashi eye hospital /ID# 267604

Fukuoka, 812-0011, Japan
Horizon Eye Specialists & Lasik Center - Sun City /ID# 252153

Sun City, Arizona, 85351, United States
Indiana University - Glick Eye Institute /ID# 235887

Indianapolis, Indiana, 46202, United States
Kitasato University Hospital /ID# 238880

Sagamihara-shi, Kanagawa, 252-0375, Japan
Lakeside Vision Center /ID# 241698

Irvine, California, 92604, United States
Logan Ophthalmic Research Inc. /ID# 252087

Tamarac, Florida, 33321, United States
Macro Trials (SMO/Network/Consortium) /ID# 266772

Austin, Texas, 78731, United States
Midwest Medical Advisors Inc /ID# 235845

Carmel, Indiana, 46290, United States
Midwest Vision Research Foundation at Pepose Vision Institute /ID# 267094

Chesterfield, Missouri, 63017, United States
National Hospital Organization Saitama Hospital /ID# 266953

Wako, Saitama, 351-0102, Japan
Nature Coast Clinical Research - Crystal River /ID# 237781

Crystal River, Florida, 34429, United States
Nippon Medical School Tama Nagayama Hospital /ID# 273428

Tama-shi, Tokyo, 206-8512, Japan
Northern New Jersey Eye Institute /ID# 241545

South Orange, New Jersey, 07079, United States
Nv Eye Surgery - Henderson /ID# 276925

Henderson, Nevada, 89052, United States
Oklahoma Eye Surgeons /ID# 252089

Oklahoma City, Oklahoma, 73112, United States
Ophthalmic Consultants of Boston /ID# 236535

Boston, Massachusetts, 02129, United States
Piedmont Eye Center /ID# 246455

Lynchburg, Virginia, 24502, United States
Premiere Practice Management LLC /ID# 235957

Torrance, California, 90505, United States
Private Practice - Dr. James D. Branch /ID# 234560

Winston-Salem, North Carolina, 27101, United States
Rutgers New Jersey Medical School Campus, Doctors Office Center /ID# 234365

Newark, New Jersey, 07103-2425, United States
Sacramento Eye Consultants /ID# 241697

Sacramento, California, 95815, United States
San Antonio Eye Center /ID# 272087

San Antonio, Texas, 78215, United States
Scott and Christie and Associates /ID# 252284

Cranberry Township, Pennsylvania, 16066, United States
Silverstein Eye Centers /ID# 266767

Kansas City, Missouri, 64133, United States
St. George Eye Center /ID# 236200

St. George, Utah, 84790, United States
Tekwani Vision Center /ID# 235149

St Louis, Missouri, 63128, United States
The Eye Research Foundation /ID# 234528

Newport Beach, California, 92663-3637, United States
The Ohio State University /ID# 267590

Columbus, Ohio, 43210, United States
The University of Tokyo Hospital /ID# 238871

Bunkyo-ku, Tokyo, 113-8655, Japan
Thomas Eye Group PC /ID# 266775

Sandy Springs, Georgia, 30328, United States
United Medical Research Institute /ID# 241701

Inglewood, California, 90301, United States
University of Florida Health Ophthalmology - Jacksonville /ID# 243122

Jacksonville, Florida, 32209-6533, United States
University of Illinois Hospital and Health Sciences System /ID# 253630

Chicago, Illinois, 60607, United States
University of Yamanashi Hospital /ID# 238642

Chuo-shi, Yamanashi, 409-3898, Japan
Vanderbilt Eye Institute /ID# 266915

Nashville, Tennessee, 37232-0025, United States
Vistar Eye Center /ID# 234811

Roanoke, Virginia, 24011, United States
Wolstan & Goldberg Eye Associates /ID# 241700

Torrance, California, 90505, United States

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