Hypertensive disorder

This study tests a drug called riociguat in children aged 6 to 18 who have pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. The goal is to see if the drug is safe and how the body processes it at differen…

This phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can better slow chronic kidney disease (CKD) progression in adults with CKD and high blood pressure. About 2,500 participants will receive either the combination or dapagliflozin alone for 24 mo…

This study tests a virtual clinic where pharmacists monitor blood pressure, adjust medications, and provide telehealth support to older adults (65+) with high blood pressure. The goal is to see if better blood pressure control can also help prevent cognitive decline. About 1,000 …

This study tests a 12-week home-based digital program called eCardiacRehab for people who have had a heart procedure (PCI). The program includes video messages, modules, and tracking to support recovery. Researchers want to see if patients will use it regularly and find it accept…

This study tests whether taking 480 mg of magnesium glycinate daily for 12 weeks can lower blood pressure in adults with slightly high systolic blood pressure (130-159 mmHg). 120 participants will be randomly assigned to get the supplement or a placebo. The main goal is to see if…

This study looks at the long-term safety of an inhaled medication called seralutinib for people with pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the arteries in the lungs. About 316 participants who finished a previous seralutinib …

This study tests two programs—mindfulness training and a heart-healthy diet plan—to help Black women caregivers lower their blood pressure and stress. About 90 participants will join weekly group sessions online for 8 weeks, with follow-up calls. The goal is to see if these appro…

This early study tests a small, permanent device called the V-Wave Interatrial Shunt in 9 people with severe pulmonary arterial hypertension (PAH). The device is placed in the heart during a minimally invasive procedure to create a small opening between the upper chambers, which …

This study tests whether home visits by female community health volunteers plus regular SMS messages can help adults in Pokhara, Nepal, better control high blood pressure, type 2 diabetes, and smoking. About 2100 participants are split into two groups: one gets the home visits an…

This early-stage study tests a new drug called ADX-850 in 28 people with mild to moderate high blood pressure. The drug uses siRNA technology to target genes involved in blood pressure regulation. The main goal is to check safety and how the drug moves through the body, with a se…

This study tests a smartphone app called Liebria designed to help people manage high blood pressure. 328 adults with high blood pressure used the app at home to track and lower their readings. The goal is to see if the app can help control blood pressure and improve daily life.

This study tests a 6-month church-based program to help African Americans with uncontrolled high blood pressure. The program includes Bible study sessions led by the pastor and small group meetings focused on diet and exercise. A community health worker provides extra support if …

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study follows 116 people with open-angle glaucoma who already have a MINIject implant in their eye. Researchers will track them for up to 5 years to see if any serious device-related problems occur. No new treatment is given—this is a safety check to see how well the implant…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests whether Rhopressa eye drops can further lower eye pressure in people with glaucoma or high eye pressure who recently had laser surgery (SLT) in both eyes. About 70 adults will receive either Rhopressa or placebo drops daily for several weeks. The goal is to see i…

This study tests a mobile app called HyperCoach that provides health coaching to help people with high blood pressure manage their condition. Thirty-seven adults with hypertension who are already on medication will use the app to track blood pressure, weight, and steps, and set p…

This study looks at the long-term safety of a drug called sotatercept for people with a specific type of pulmonary hypertension caused by heart failure with preserved ejection fraction. About 130 people who completed a prior study will receive sotatercept injections and be monito…

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This study is testing the safety and right dose of a drug called selexipag in children aged 2 to 17 with pulmonary arterial hypertension (PAH), a serious condition where blood pressure in the lungs is too high. The goal is to find a dose that works like the adult version. The stu…

This study tests whether adding selexipag to standard treatment can delay disease worsening in children aged 2 to 18 with pulmonary arterial hypertension (PAH). About 138 children will receive either selexipag or a placebo, plus their usual medications. The main goal is to see if…

This phase 3 trial compares two doses of macitentan (75 mg vs 10 mg) in about 935 adults with pulmonary arterial hypertension. The goal is to see if the higher dose can delay serious events like hospitalization or death. Participants will be followed for several years.

This study looks at whether giving low-income people with diabetes or hypertension a monthly grocery card ($80 or $120) helps them control their disease and feel less stressed about food. About 4,450 adults in California are taking part. Researchers will check changes in blood su…

This study tests whether a natural supplement called nicotinamide riboside can improve artery stiffness and lower blood pressure in people with moderate to severe chronic kidney disease. About 118 adults aged 35-80 will take either the supplement or a placebo for 3 months. The go…

This study looks at whether providing medically tailored groceries can help people with type 2 diabetes and high blood pressure keep up healthy eating habits and control their blood sugar and blood pressure. About 80 adults who already took part in a meal delivery study will rece…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests whether a church-based program led by community health workers can help Black adults in Louisiana lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 812 participants from local churches will receive either a health worke…

This study tests whether sending primary care doctors a monthly report comparing their hypertension control rates to peers can improve patient care. About 93 doctors and their patients with high blood pressure are involved. The goal is to see if this feedback leads to more medica…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests a program called PACE that combines nurse support, remote blood pressure monitoring, and help with social needs (like housing or food) to improve blood pressure control in Black patients. About 500 adults with uncontrolled high blood pressure will take part acros…

This study tests an experimental drug called QCZ484, given as an injection under the skin every 6 months, for people with mild to moderate high blood pressure. About 385 adults aged 18 to 75 are taking part. The goal is to see if the drug safely lowers blood pressure compared to …

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This study tests whether monthly home visits from trained health agents can help people in poor, high-altitude communities in Peru better control their high blood pressure and diabetes. Over 1,000 participants will either receive these visits for a year or get usual care. The goa…

This Phase 3 trial tests a daily pill called orforglipron in 487 adults with high blood pressure who are also overweight or obese. The study measures how well the drug lowers blood pressure and body weight compared to a placebo. It is currently active but not recruiting.

This Phase 3 trial is testing a once-daily pill called orforglipron in nearly 1,000 people with high blood pressure who are also overweight or have obesity. The study compares the drug to a placebo to see if it safely lowers blood pressure. Participants may be untreated or on sta…

This Phase 3 study tests an experimental once-daily pill called orforglipron in about 487 adults who have both high blood pressure and obesity or overweight. The main goal is to see if the drug lowers blood pressure more than a placebo. Researchers will also check for changes in …

This early-phase study tests a single injection of ART101 in 16 adults with high blood pressure. The goal is to see if it is safe and how it affects blood pressure over 24 weeks. Participants receive either 600 mg or 800 mg of the drug and are closely monitored.

This study is testing the long-term safety and tolerability of an inhaled treprostinil powder (TPIP) in people with pulmonary arterial hypertension (PAH). About 91 participants who completed earlier TPIP studies will receive the drug for up to several years. Researchers will moni…

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study tests whether eye pressure-lowering medication can slow the progression of severe nearsightedness (high myopia) in adults. Researchers will measure changes in eye length and vision over time. The trial includes 152 participants aged 18 to 65 with worsening high myopia …

This study tests whether nurse-led health coaching can help adults with high blood pressure in Huayuan County, China, better manage their condition. About 78 participants will receive either standard care or additional coaching sessions over six months. The goal is to see if coac…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…

This study tests a new daily pill called QLS1410 in 260 adults whose high blood pressure remains high despite taking two or more medications. Participants will receive either QLS1410 or a placebo for 12 weeks. The main goal is to see if QLS1410 can lower systolic blood pressure m…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This Phase 2 trial tests an inhaled drug called LAM-001 (sirolimus) in 85 adults who have pulmonary hypertension (high blood pressure in the lungs) along with interstitial lung disease (lung scarring). The study compares the drug to a placebo to see if it improves blood flow in t…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study tests an implant called AGN-193408 SR that is placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 100 participants will receive the implant, and some will also get standard eye drops for comparison. The goal is to se…

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This early-stage study by Pfizer tests a new drug called PF-07868489. First, it will be given to healthy volunteers to check safety and how the body processes it. Then, people with pulmonary arterial hypertension (PAH) will receive repeated doses over 24 weeks to see if it helps …

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …

This study tests a device called TIVUS that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. It includes 25 adults with uncontrolled stage 2 hypertension who have not responded well to medication. The main goal is to see if the proced…

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This study tests a new eye drop called DE-117B in 345 Chinese adults with open-angle glaucoma or high eye pressure. The goal is to see if it safely lowers eye pressure better than an existing drug. Participants use the drops once daily for at least 4 weeks, with long-term follow-…

This study looks at whether automatically sending home blood pressure readings to doctors and getting automated advice through a patient portal can help people with high blood pressure lower their numbers better than just writing them down. About 1,300 adults with uncontrolled hy…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study tests a mobile health system called mGlide that helps patients with uncontrolled high blood pressure monitor their BP at home and automatically share readings with their healthcare team. The system alerts doctors when BP goes off track, allowing for timely medication a…

This Phase 2 trial tests an experimental eye drop called BL1107 against a standard treatment (timolol) in 252 adults with glaucoma or high eye pressure. Participants use the drops twice daily for 28 days. The study measures changes in vision and eye pressure to see if BL1107 is s…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study tests a device that uses ultrasound to burn nerves around the kidney arteries, aiming to lower blood pressure in people with autosomal dominant polycystic kidney disease (ADPKD) whose blood pressure remains high despite medication. 44 participants will be randomly assi…

This study tests an inhaled drug called frespaciguat (MK-5475) in 129 adults who have high blood pressure in their lungs caused by COPD. The main goal is to see if the drug helps people walk farther in 6 minutes after 24 weeks compared to a placebo. Participants take one daily in…

This phase 3 trial tests a procedure called renal denervation, where a small amount of alcohol is injected around the kidney nerves to calm overactive signals that raise blood pressure. 142 people with uncontrolled hypertension will either get the real procedure or a sham (fake) …

This study tests a smartphone app called MED-AD that sends reminders and tracks medication use for people with heart disease, high blood pressure, or high cholesterol. About 1,000 adults in Oman will be randomly assigned to use the app, receive daily text reminders, or get usual …

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This early-stage trial is testing a single biodegradable implant placed in the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. The implant slowly releases medication over time and then dissolves. The study includes 12 adults and focuses on safety,…

This study tests whether the drug eplerenone works better than amlodipine for controlling high blood pressure in Black adults who carry a specific gene variant (LSD1 risk allele). About 300 participants will follow a controlled diet and take escalating doses of one of the two dru…

This pilot study tests whether checking blood pressure at home and talking to a pharmacist weekly by phone can help manage uncontrolled hypertension after an emergency department visit. Twenty-four participants will be split into two groups: one receives the home monitoring and t…

This study looks at how the timing of meals and sleep patterns influence blood sugar, heart health, and weight loss in adults with type 2 diabetes, obesity, or high blood pressure. Researchers will provide nutritional guidance and track changes in weight, lab results, and body me…

This study tests a device that uses ultrasound to disrupt overactive nerves in the kidneys, which can drive high blood pressure. About 282 adults with hypertension will either get the real procedure or a sham (fake) procedure. The goal is to see if this treatment safely lowers bl…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study looks at the long-term safety of relacorilant, a drug for people with Cushing syndrome. It includes 125 adults who previously completed a relacorilant study and may benefit from continued treatment. Researchers will track side effects over time to see if the drug is sa…

This study is testing a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. It includes 1,000 people whose blood pressure stays high despite taking three or more medications, or who can't tolerate those drugs. Researchers …

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This study tests a device called Paradise™ that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers will compare the device to a sham (fake) procedure in 154 adults with hypertension who are already taking two blood pressure …

This study tests whether giving people free boxes of fruits and vegetables along with nutrition education can improve health in three Mississippi counties with high rates of diabetes, obesity, and poverty. About 300 adults with high blood sugar or obesity will receive produce and…

This study compares two ways to help stroke survivors control their blood pressure using telehealth. About 86 participants will receive either enhanced remote monitoring or standard care. The goal is to see which approach better helps people reach a safe blood pressure target and…

This study looks at whether eating oats for 6 weeks can improve cholesterol, blood pressure, and gut health in people who are overweight or have high cholesterol. Participants will follow a low-gluten diet rich in either oats or rice. Researchers will measure blood fats, inflamma…

This study looks at the long-term safety of an inhaled drug called GB002 for people with pulmonary arterial hypertension (PAH), a serious lung condition. It includes 74 patients who already completed a previous GB002 study. Researchers will track side effects and measure how far …

This study tests a new drug, Oxacom®, in 200 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. The drug is given in different doses to see if it can lower pressure in the lung's blood vessels better than a placebo. The goal…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study tests a new app called COACH that helps patients and their doctors work together to control high blood pressure. The app connects home blood pressure readings to the patient's medical record and sends reminders based on behavioral science. About 550 adults with high bl…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study is a patient registry that follows 300 adults with pulmonary arterial hypertension (PAH) who are starting or recently started Orenitram. Researchers will track how well patients tolerate the drug and how it affects their daily function and symptoms over 78 weeks. The g…

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study tests whether having more frequent checkups with an obstetric provider or a study nurse during the first year after childbirth can help women with high blood pressure or diabetes manage their health better. One hundred women with Medicaid insurance who had these condit…

This study tests a new inhaled drug called L606 (liposomal treprostinil) in 28 adults with pulmonary arterial hypertension or PH-ILD. The goal is to see if it is safe and tolerable when taken twice daily, both short-term and over a year. Participants either switch from another in…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study tests if a smartphone app called OptiZ can help people with high blood pressure get better control of their condition. Participants use the app to track their blood pressure, medication, and side effects, and share reports with their doctor for personalized dose adjust…

This phase 3 trial tests an inhaled drug called seralutinib for people with pulmonary hypertension (high blood pressure in the lungs) caused by interstitial lung disease (lung scarring). About 480 adults will receive either seralutinib or a placebo for 24 weeks, followed by a lon…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study looks at whether a program that combines remote patient monitoring with care management can help people with uncontrolled hypertension lower their blood pressure. About 130 participants will be followed for up to 24 months. The goal is to see if this approach can be us…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This study tests a program that helps adults with type 2 diabetes, high blood pressure, or high cholesterol address social needs like food, housing, and transportation. About 4,800 participants will be screened during primary care visits and offered support from providers, care c…

This study tests whether giving women a home blood pressure monitor plus regular pharmacist follow-up helps lower blood pressure better than usual care. 368 women with high blood pressure will be randomly assigned to either the home monitoring program or standard care. The pharma…

This study looks at whether a home blood pressure monitoring program helps people with high blood pressure get better control. About 24,000 adults from primary care clinics are taking part. The program includes support and education to help patients measure and manage their blood…

This study looks at whether a cuffless blood pressure monitor (CART BP Pro) can help manage high blood pressure better than usual care in Korean adults whose blood pressure is not well controlled. About 288 participants will either use the device to guide their treatment or recei…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with group 2 pulmonary hypertension (high blood pressure in the lungs). About 48 participants will take tadalafil or a placebo for 12 weeks. Researchers will measure how far they can w…

This study tests whether community health workers (CHWs) who screen patients for social needs like food, housing, or transportation and connect them to resources can improve blood sugar and blood pressure control. About 3,120 adults with uncontrolled diabetes or hypertension from…

This study looks at whether the drug bevacizumab can help people with a rare condition called hereditary hemorrhagic telangiectasia (HHT) who have severe liver problems leading to high heart output and possible heart failure. Researchers will check heart function before and after…

This study tests a 6-month digital care program for adults aged 50+ with type 2 diabetes and at least one other chronic condition like high blood pressure or kidney disease. The program combines online education, phone support, a mobile health app, home visits, and personalized c…

This study follows 160 people who have or will get a CODMAN CERTAS Plus valve, a device implanted in the brain to drain extra fluid. The main goal is to see if the valve is placed correctly and works without problems 30 days after surgery. Participants include children and adults…

This Phase 2 trial tests an inhaled medication called mosliciguat in 135 people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs. Participants are randomly assigned to receive either the drug or a placebo for 16 weeks. The study measure…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug remains s…

This study tests whether a specially designed app can help women who had high blood pressure or diabetes during pregnancy get the recommended heart check-ups after giving birth. About 400 women from Oslo University Hospital will either use the app or receive standard care. The go…

This study looks at the long-term safety and effectiveness of a drug called lorundrostat for people with high blood pressure. About 1,076 adults who have already taken lorundrostat in a previous study will continue taking it for up to 36 weeks. The goal is to see if the drug keep…

This trial tests whether trained village health workers, using a smartphone app, can effectively manage high blood pressure in rural Lesotho. About 1,350 participants with either uncontrolled or controlled hypertension will receive either community-based care (medication and moni…

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study tests a new fixed-dose combination pill containing three blood pressure medicines (telmisartan, amlodipine, and chlorthalidone) against another triple combination (with hydrochlorothiazide instead of chlorthalidone) in elderly patients whose blood pressure is not well …

This study tests a special device that uses radiofrequency energy to calm overactive kidney nerves, which can help lower blood pressure. It is for adults aged 18-65 with uncontrolled high blood pressure and chronic kidney disease who are already on at least two blood pressure med…

This study tests different strategies to help people from diverse backgrounds monitor their blood pressure at home. About 330 adults with uncontrolled high blood pressure will receive training on using a blood pressure monitor and a mobile app, plus SMS reminders and education. T…

This study tests a program to help control high blood pressure in adults aged 35 and older living in rural Pakistan. The program includes regular blood pressure checks, home health education, and referrals to doctors. Researchers want to see if this approach can be effectively us…

This study tests whether providing home-delivered DASH diet groceries, with help from a dietitian, can lower blood pressure in Black adults who already take medication for hypertension and live in areas with limited access to healthy food. About 150 participants will receive week…

This study tests whether interactive storytelling modules can help adults in a large Vietnamese city better control their high blood pressure. Seven hundred participants with uncontrolled hypertension will receive the storytelling intervention or usual care. The goal is to see if…

This study tests a dual GIP/GLP-1 drug (a type of diabetes medication) in 120 adults in Kazakhstan who have both chronic heart failure and type 2 diabetes. Participants take the drug for 40 weeks and have regular heart tests, blood work, and genetic checks. The goal is to see if …

This study tests an implanted catheter and pump system that delivers Remodulin, a drug for pulmonary arterial hypertension (PAH), directly into the bloodstream. The goal is to see if this device is safe for long-term use. The trial includes 64 patients who already use the system.…

This study tests different patient- and clinic-focused strategies to help people with high blood pressure get it under control. Researchers will compare changes in blood pressure readings from clinic and home monitoring. The goal is to find the most effective approach for English…

This study tests whether regular exercise and cognitive training, alone or together, can improve physical and mental function in adults aged 60+ who have had a stroke and also have high blood pressure or diabetes. Over 400 participants from five Chinese cities will take part in 1…

This study looks at how to best help primary care clinics adopt team-based home blood pressure monitoring. Over 5,700 patients and their care teams will use a program where patients send in their home readings and get support from doctors, nurses, and community resources. The goa…

This study compares two types of peritoneal dialysis—standard and incremental—in 100 adults starting dialysis. The goal is to see if using less dialysis solution (incremental) helps preserve remaining kidney function and reduces cell damage compared to the standard approach. Part…

This study tests whether helping people who sleep less than 6.5 hours per night extend their sleep can lower their blood pressure. Researchers will compare an 8-week sleep coaching program to general health education in 110 adults with prehypertension or mild hypertension. The ma…

This study reviews 100 patients with open-angle glaucoma who had two minimally invasive surgeries (Hydrus microstent and iTrack canaloplasty) along with cataract surgery. Researchers want to see if this combination lowers eye pressure and reduces the need for glaucoma medications…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study tests whether hydroxytyrosol, a natural antioxidant from olives, can improve blood vessel function in pregnant women with high blood pressure. Fifty-two women will take either the supplement or a placebo for 4 weeks. Researchers will measure changes in blood markers an…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study tests whether carefully managing blood pressure during a clot-removal procedure for stroke can improve patient recovery. About 550 people having emergency clot retrieval will have their systolic blood pressure kept within a specific target range. Researchers will then …

This study looked at whether a 36-week program of exercise, nutrition advice, and psychoeducation could improve body composition, blood markers, and physical performance in 40 older women, some with high blood pressure and some without. The women exercised regularly and received …

This study tests whether motivational interviewing, a type of counseling, can help people with high blood pressure living in semi-rural areas better understand their condition, feel more confident, and stick to their treatment. About 100 adults aged 25-59 will either receive four…

This study tests whether colchicine, a drug used for gout, can improve blood vessel stiffness and heart function in people with high blood pressure. About 150 adults with hypertension and additional risks like diabetes or high cholesterol will take colchicine or a placebo daily f…

This large trial tests whether a program led by village doctors can help control high blood pressure in rural China. Over 33,000 participants will receive training, discounted medications, and a simple treatment protocol. The study aims to see if this approach improves blood pres…

This study looks at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent high blood pressure or lower it in healthy adults. Over 25,000 people are taking part, with a smaller group having their blood pressure monitored around the clock. The goal is t…

This study tests whether empagliflozin, a diabetes medicine, can improve right heart function in 78 adults with pulmonary arterial hypertension (PAH). Participants continue their usual PAH treatments and receive either empagliflozin or a placebo. The main goal is to see if the dr…

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study tests whether quickly starting and increasing a medication called treprostinil can lower blood pressure in the lungs and improve the heart's pumping ability in people with pulmonary arterial hypertension (PAH). The trial involves 52 adults with PAH and will measure cha…

This study was designed to test whether a new fixed-dose combination of two blood pressure medicines (olmesartan and chlorthalidone) works as well as an existing combination (olmesartan and hydrochlorothiazide) in people with untreated high blood pressure. The trial was withdrawn…

This study aimed to compare two different combination pills for controlling high blood pressure: one with olmesartan and chlorthalidone, and another with olmesartan and hydrochlorothiazide (Benicar HCT). The trial was planned for people with uncontrolled hypertension but was with…

This study looks at the long-term safety of a medicine called sotatercept for people with pulmonary arterial hypertension (PAH). Participants from an earlier study can join and receive weight-based doses every 3 weeks. The main goal is to see if the medicine is safe and well-tole…

This study tests whether a gamification program, along with support from a partner and updates to their doctor, can help 84 adults with high blood pressure and high cholesterol take their medications more consistently. Participants who have struggled with adherence will either re…

This study tests whether a powder made from haskap berries can help lower blood pressure and improve alertness in women aged 35 and older. Thirty-two participants will take either the berry powder or a placebo for six weeks, then switch after a break. The goal is to see if this n…

This study tests whether a culturally tailored telehealth coaching program led by community health workers can help South Asian adults with type 2 diabetes and high blood pressure get their blood pressure under control. About 450 participants will either receive the coaching or u…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This study tests whether intensive blood pressure treatment after childbirth can improve women's long-term heart health. Researchers will enroll 60 women who had high blood pressure during pregnancy and give them nifedipine to keep their BP below 140/90 mmHg. The goal is to see i…

This study tests whether giving blood pressure medication to women after childbirth can prevent hospital readmissions and reduce severe high blood pressure. About 300 women with preeclampsia will either receive standard care or start blood pressure drugs like labetalol or nifedip…

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot or will not use a CPAP machine. Researchers will measure blood pressure changes over 36 weeks in 122 p…

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This study compares different ways of performing a laser treatment called selective laser trabeculoplasty (SLT) for people with open-angle glaucoma or high eye pressure. 400 participants will receive SLT using one of several protocols, and researchers will track how much their ey…

This study looks at the best way to repeat a laser treatment called SLT for people with open-angle glaucoma or high eye pressure. Researchers will compare different treatment methods in 400 participants who were already in an earlier SLT trial. The goal is to see how well repeat …

This study tests if a new, automated laser treatment (DSLT) works as well as the standard laser treatment (SLT) for lowering eye pressure in people with open-angle glaucoma. About 51 adults will receive one of the two treatments and be followed for 12 months. The goal is to see i…

This study tests whether patient- and provider-focused strategies can help more people control their blood pressure. About 540 adults with hypertension from Los Angeles County clinics will take part. Clinics are randomly assigned to receive either provider outreach, patient outre…

This study tests whether a 12-week program of exercise and diet counseling can improve insulin sensitivity and heart function in people with pulmonary arterial hypertension (PAH). The 34 participants have stable PAH and are already on standard medications. The goal is to see if l…

This study compares two types of aerobic exercise—interval training and continuous training—over 4 months in 72 adults with resistant hypertension. The goal is to see which type better lowers 24-hour blood pressure and improves related health markers. Participants are randomly as…

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

This study tests whether waiting to clamp the umbilical cord until after the baby's lungs have filled with air can reduce dangerous lung blood pressure (pulmonary hypertension) in newborns with congenital diaphragmatic hernia (CDH). About 140 infants with left-sided CDH will be r…

This study will follow 800 adults in Turkey with high blood pressure or chronic chest pain (angina) who are already taking benidipine. Researchers will track how well the drug controls blood pressure and eases chest pain symptoms over time. The goal is to see how benidipine works…

This pilot study tests whether temporarily raising blood pressure with drugs like phenylephrine or norepinephrine can reduce brain damage in people having a major stroke. About 40 adults with large-vessel blockage strokes will receive the blood pressure boost during standard clot…

This study follows 23 people who received a special lens implant that slowly releases a glaucoma drug (bimatoprost) during cataract surgery. Researchers want to see if it keeps eye pressure low and vision clear for up to 7 years. The goal is to learn whether this combination devi…

This Phase 2 trial tests whether satralizumab, an antibody that blocks IL-6 (a protein involved in inflammation), can improve blood flow in the lungs of people with pulmonary arterial hypertension (PAH). The study includes 20 adults in Japan who have high IL-6 levels and haven't …

This study looks at whether a new computer program called IMPULSE can better detect pulmonary hypertension (high blood pressure in the lungs) using standard heart ultrasound. About 200 adults with unexplained breathlessness or risk factors will be checked. The goal is to see if t…

This study checks if a Withings smart scale can accurately spot signs of high blood pressure by looking at body measurements like weight and heart rate. Researchers compared the scale's results to a standard blood pressure cuff in 2,500 adults. The goal is to see if the scale wor…

This study tests a new, gentle device called Boppli that continuously measures blood pressure in newborn babies in the NICU. Researchers will compare it to the standard blood pressure cuff to see if it works better at finding high blood pressure. The study includes 30 infants at …

This study tests a new urine test called CercaTest™ Red to predict preeclampsia in pregnant women who show signs of the condition. Preeclampsia is a serious complication involving high blood pressure and organ damage. The test is designed to be used at the point of care, giving q…

This study is testing whether a special home blood pressure monitor that can detect atrial fibrillation (AFib) helps diagnose the condition faster in older adults with high blood pressure. About 1,900 participants aged 60 and older will take daily blood pressure readings and answ…

This study aimed to see if a handheld device called CPMX3 could safely estimate brain pressure in children by measuring pressure in a forehead vein. It planned to compare these readings with standard invasive measurements in children aged 8 to 21 who already had brain pressure mo…

This study tests whether a special MRI technique called MR elastography can accurately measure high pressure inside the skull without needing a lumbar puncture (spinal tap). Researchers will compare the MRI results with standard tests in 200 people with and without high brain pre…

This study tests whether Withings bathroom scales can accurately measure pulse wave velocity (PWV), a key indicator of vascular stiffness. Researchers will compare readings from the scales with a standard medical device in 176 adults, including those with high blood pressure, sle…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study tests a new type of MRI scan (qMT-MRI) to see if it can detect scarring in the kidneys of people with high blood pressure and narrowed kidney arteries. Researchers will compare the scan results to kidney function and injury markers. If it works, this could offer a safe…

This study looks at whether helping communities switch to cleaner cookstoves can lower indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will take part. Some families get extra support to use the new stoves, while others just receive informat…

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This study tests whether a culturally tailored, skills-based program delivered by community health workers can help Latinx and Vietnamese families in Santa Ana, CA, improve their heart health and prevent high blood pressure. About 483 participants will receive either the special …

This study tests whether using a smartphone app and a home blood pressure monitor can help prevent heart disease in women who had high blood pressure during pregnancy. 120 women who gave birth at Northwestern Memorial Hospital will use these digital tools for 12 months after deli…

This study tests a community-based program called Thriving Hearts across ten North Carolina counties. Pregnant individuals at risk for hypertensive disorders receive a care kit with a home blood pressure monitor and stress management tools, plus extra support from healthcare prov…

This study tests whether providing fresh meals, health coaching, and education to high-risk pregnant women can reduce the chance of developing gestational diabetes, high blood pressure, or preeclampsia. 69 women in Milwaukee are randomly assigned to either receive the program or …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This study tests whether a program using church-based health coaches can help rural Black adults with slightly high blood pressure lower it. Participants from 30 churches in Alabama will get health education and online cooking and exercise classes. Half will also get a health coa…

This study tests whether personalized counseling, leaflets, and text messages can help 1,700 healthy adults living in Dhaka slums avoid high blood pressure. Participants receive 20 face-to-face sessions on diet, exercise, and tobacco use. The goal is to see if these lifestyle cha…

This study tests whether collecting sexual health information electronically during routine gynecologic visits can increase the use of PrEP, a medication that prevents HIV. About 1,170 women aged 15-65 who are not living with HIV will participate. The goal is to see if this appro…

This phase 4 trial tests whether taking metformin daily before 20 weeks of pregnancy can reduce the risk of high blood pressure disorders, like preeclampsia, in pregnant women with type 1 diabetes. About 60 women will receive either metformin plus standard care or standard care a…

This large, phase 4 trial is testing whether berberine, a natural compound, can prevent heart disease and diabetes in over 2,000 high-risk adults in China. Participants take berberine or a placebo twice daily, plus receive lifestyle advice. The study tracks blood sugar and heart …

This study investigates how aspirin can prevent preeclampsia, a serious pregnancy condition, in first-time mothers at high risk. Researchers will compare biological changes in 200 women with low or high risk, some taking aspirin and some not. The goal is to understand how aspirin…

This pilot study tests whether remote monitoring and guideline-directed therapy can prevent heart dysfunction in African American women who had preeclampsia. Twenty participants will use a tablet, blood pressure cuff, and scale at home for three months after delivery. The goal is…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests whether a mobile health unit program can help Black adults in Detroit lower their blood pressure and prevent stage 2 hypertension. Participants receive personalized lifestyle coaching from community health workers. The goal is to address social barriers like food…

This study tests whether taking riboflavin (vitamin B2) and a form of folate can prevent high blood pressure in pregnant women who have a specific gene variant (MTHFR TT). About 2250 women in their first trimester are being recruited. Those with the gene variant will receive the …

This study tests whether taking L-citrulline, a natural amino acid supplement, daily from early pregnancy can prevent high blood pressure conditions like preeclampsia in women expecting their first child. About 338 healthy first-time mothers between 12-16 weeks pregnant will rece…

This study tests whether an 8-week phone-based mindfulness program can reduce stress and blood pressure in 150 pregnant women at risk for hypertensive disorders. Participants will complete daily surveys and wear biosensors to track stress and heart activity. The goal is to see if…

This study tests whether a smartphone-based stress management program can help Black men with hypertension lower their blood pressure and feel less stressed. About 135 participants will either use a culturally tailored app (m-CBSMi) or take a standard online stress course. Resear…

This study looks at whether a program that combines physical activity with support from a peer is acceptable and practical for women living with both HIV and high blood pressure. About 50 women aged 40 and older will take part. The goal is to see if women stick with the program a…

This study looks at whether progressive muscle relaxation and finger grip exercises can lower stress, anxiety, and fatigue while improving sleep in pregnant women with preeclampsia. About 90 women will be split into three groups: one doing relaxation exercises, one doing finger g…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This study tests whether a virtual reality (VR) wellness program can help Black women with high blood pressure reduce stress and improve heart health. Sixty Black women in South Florida will either use a five-week VR program or receive standard educational materials. Researchers …

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study tests whether 10 weeks of supervised exercise training can improve heart function, oxygen use, and quality of life in people with heart failure and pulmonary hypertension. Forty participants will do three sessions per week at a cardiac rehab clinic. The goal is to see …

This study tests whether exercise delivered through immersive virtual reality can improve physical performance, muscle strength, fatigue, and quality of life in 32 adults with idiopathic pulmonary arterial hypertension. Participants will do virtual reality exercises and be measur…

This study tests whether whole-body aerobic training (like brisk walking) or isolated leg training (with weights) better improves symptoms and quality of life in people with pulmonary arterial hypertension (PAH). About 45 participants with PAH will be assigned to one of the two e…

This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual …

This study looks at whether low-resistance exercise (like light strength training) can safely help people with pulmonary arterial hypertension (PAH) feel better and be less frail. About 20 adults with stable PAH will try the program. Researchers will track safety, how well people…

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study tests whether six weeks of daily breathing exercises against resistance can improve heart and lung function in people with pulmonary hypertension. Four participants will do 30 resisted breaths per day, five days a week. Researchers will measure changes in heart pressur…

This study looks at which local anesthetic works better and is safer for people with high blood pressure who need a tooth pulled. Sixty adults with controlled hypertension will get either articaine with epinephrine or mepivacaine without epinephrine. Researchers will measure pain…

This study looks at whether weekly group drumming for 8 weeks can improve the health of people aged 60 and older living in the community. Researchers will measure changes in quality of life, depression, sleep, and blood pressure. 300 participants will take part, and the goal is t…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study tests whether changing how combination blood pressure pills appear in the electronic health record can encourage doctors to prescribe them more often. Over 12,000 patients will be included, and researchers will track whether a simple label like "(PREFERRED)" makes a di…

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study looks at whether personalized digital messages can help 12,000 adults with uncontrolled high blood pressure stick to their treatment plan. The messages are tailored using artificial intelligence to encourage doctor visits, medication adherence, and home blood pressure …

This study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study aimed to see if a personalized exercise app (Gingko Active) could improve physical function in adults aged 45 and older better than a standard exercise booklet. The trial was withdrawn before any participants enrolled, so no results are available. The app was designed …

This study tests a training program that teaches doctors how to better talk with, listen to, and involve patients in their own care. About 180 doctors and their patients with high blood pressure will take part. The main goal is to see if the training is practical and acceptable, …

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study looks at how a common glaucoma eye drop (latanoprost with preservatives) changes the natural bacteria living on the eye's surface. Researchers will compare the eye bacteria of 45 newly diagnosed glaucoma patients before and after at least 6 months of treatment. The goa…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study looks at how eating mostly ultra-processed foods (like packaged snacks) compared to less-processed foods (like whole fruits and vegetables) affects blood pressure and other heart health markers. About 79 overweight adults will follow special diets to see the difference…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

This study is tracking over 1,200 adults in Kazakhstan who have high blood pressure to see how many also have signs of chronic kidney disease (CKD). Researchers will measure things like protein in urine and kidney function. The goal is to understand how often CKD goes undiagnosed…

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study tests whether a tablet-based decision support system helps frontline health workers in India and Nepal provide better antenatal care. About 1,320 pregnant women will take part. The tool guides workers to check blood pressure, blood sugar, urine protein, and hemoglobin,…

This study looks at whether a 2-minute step test can accurately measure exercise ability in people with pulmonary hypertension, compared to the standard 6-minute walk test. Researchers will enroll 35 adults with the condition and measure oxygen use, heart rate, and breathlessness…

This study tests a 10-week educational program called HomeStyles-China, designed to help Chinese American adults improve their diet, increase physical activity, and reduce risk factors for heart disease and diabetes. Researchers will enroll 400 participants and measure changes in…

This study looks at whether giving extra support to community health centers helps them screen patients for non-medical needs like food or housing and refer them to community resources. Twenty health centers will be randomly assigned to get this support or not. The goal is to see…

This study looks at how a special heart device (BackBeat CNT) affects nerve activity in 15 people with high blood pressure who already have the device implanted. Researchers measure nerve signals and blood pressure with and without the device turned on. The goal is to understand …

This study looks at 60 adults with resistant hypertension—high blood pressure that doesn't improve even with multiple medications. Researchers measure artery stiffness using a simple, non-invasive test to see if it can help identify patients who aren't taking their drugs as presc…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study looks at how exercise affects gut bacteria and blood pressure in African Americans, who face higher rates of hypertension. Researchers will measure changes in blood pressure and gut microbes in 36 sedentary adults aged 30-50. The goal is to understand if exercise impro…

This study looks at over 1,000 South African children ages 5 to 9 to understand why some develop early signs of high blood pressure and heart problems. Researchers will measure blood pressure, body fat, and fitness, and test blood for early warning markers. The goal is to find wa…

This study reviews past clinical trials to see if people with high blood pressure who get it under control with medication actually live longer or have fewer heart-related deaths. Researchers will analyze data from 100 adults who achieved their blood pressure targets. The goal is…

This study tests a new classroom setup where traditional desks are replaced with standing desks, fitballs, and wall boards to get kids moving more. Researchers will track 500 students in Spain to see if this reduces sitting time and improves thinking, fitness, and well-being. The…

This study was designed to see if a test using acetylcholine could predict whether people with congenital heart disease and high blood pressure in the lungs would develop worsening high blood pressure after surgery to close a heart shunt. The test would have measured how well the…

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study tests whether ultrasound of the lungs and a major vein (vena cava) can accurately measure fluid status in women with mild preeclampsia after they receive spinal anesthesia for delivery. Researchers will compare ultrasound findings to traditional methods in 62 participa…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to compare virtual clinic visits (using video calls on tablets) with in-person visits for people with vascular diseases. Doctors would classify patients as low, moderate, or high risk for treatment after each visit type. The goal was to see if virtual visits co…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study watches 50 people with chronic lymphocytic leukemia (CLL) who are starting a type of drug called a BTK inhibitor. These drugs can cause high blood pressure and irregular heartbeats. Participants will use a wearable device at home to track their heart rhythm and blood p…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study looks at whether adding special blood tests (biomarkers) to the usual heart-lung exam can help doctors pick the right therapy for people with pulmonary hypertension. About 100 adults undergoing a routine heart catheterization will have extra blood samples taken from th…

The ALOHA study is a community-based research project for adults aged 50 and older in the Washington, D.C., Maryland, and Virginia area. Over five years, participants receive annual health assessments—including physical and cognitive tests—and get a personalized 'Health Passport'…

This study examines the links between sleep bruxism (teeth grinding during sleep) and sleep quality, heart health, thyroid function, and mood. Researchers will give some participants opipramol, a drug that may reduce grinding activity, and monitor them with sleep tests. The goal …

This study looks at 116 adults who had glaucoma stent surgery up to 2 years ago. Researchers use a special eye scan (OCT) to check if the tiny stents are in the right position and how that affects eye pressure. The goal is to learn how often stents are misplaced and whether prope…

This study follows about 800 pregnant women in Somaliland to understand the physical, cultural, and social factors affecting their health during pregnancy, childbirth, and after birth. Researchers will also work with the community to create better contraceptive counseling materia…

This study is testing whether women with high-risk pregnancies can be safely monitored from home instead of staying in the hospital. Researchers will check if home monitoring is practical, safe, and costs less, while also improving patients' quality of life. About 250 pregnant wo…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study aimed to see if data from Withings devices (like smart scales and blood pressure monitors) could predict uncontrolled high blood pressure. It planned to enroll adults in the U.S. who had used Withings devices for at least two years. The study was withdrawn before any p…

This long-term study is following over 10,000 healthy adults aged 50-75 to understand how the body's natural regulation of heart rate and blood pressure relates to future heart disease, stroke, and sudden death. Participants undergo non-invasive tests like a special ECG and carot…

This study aimed to see if telling surgery patients about their high blood pressure would lead them to get a formal diagnosis. Researchers planned to call 108 patients with elevated readings and follow up six months later. However, the study was withdrawn before enrolling anyone,…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study is testing a new smartphone app called ENHANCe that helps family doctors manage patients with high blood pressure using home blood pressure readings. The app scans home readings and gives the doctor a recommendation on how to adjust treatment. The study will enroll 116…

This study looks at whether people with pulmonary arterial hypertension (PAH) have changes in thinking skills like memory and attention. Researchers will compare 30 PAH patients to healthy volunteers using computer-based tests. The goal is to better understand how PAH might affec…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study looks at a specific genetic change found in some people with high blood pressure. Researchers want to see if this change is linked to a condition called primary aldosteronism, which can sometimes be cured with surgery. About 76 men from a larger Swedish health study wh…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study was designed to see if a non-invasive finger cuff device could accurately measure how well the heart pumps blood in people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). The goal was to replace the usual invasive ri…

This study was designed to find early warning signs of high blood pressure in the lungs after mitral valve surgery. Researchers planned to use blood tests and heart imaging to detect problems that could be deadly if missed. The study was withdrawn before enrolling any participant…

This study looks at how sleep and your internal body clock influence blood pressure at night. Researchers will monitor over 1,400 participants using a constant routine protocol—staying awake in a dim room for over 24 hours—to measure melatonin, body temperature, and blood pressur…

This study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3,000 participants over time to see how the heart changes and who develops serious problems.…

This study looks at whether substances produced by gut bacteria, called TMAO, can help predict high blood pressure during pregnancy. Researchers will track 200 pregnant women by collecting blood and urine samples throughout their pregnancies. The goal is to find early warning sig…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study looks at people with high blood pressure whose levels don't drop normally during sleep, a condition linked to worse health outcomes. Researchers will use wearable devices and smartphone apps to monitor blood pressure patterns over 24 hours. The goal is to understand ho…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This observational study aims to measure how well the heart pumps blood in people with untreated preeclampsia compared to healthy pregnant women. Researchers will use a non-invasive ultrasound (echocardiography) to check heart function at rest, after blood pressure medication, an…

This study looks at whether a special training program can help family doctors use focused heart ultrasound (FoCUS) to accurately detect common heart conditions like heart failure and valve disease. About 500 patients will get both a family doctor's FoCUS and a cardiologist's ful…

This study looks at why women who had preeclampsia may have lasting blood vessel problems and inflammation. Researchers will test a drug called eplerenone on a small patch of skin to see if it improves blood vessel function. The study involves 40 women, some with a history of pre…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study looks at how changing your body position or drinking water can cause temporary spikes in eye pressure. Researchers will measure these changes in healthy volunteers and in people with glaucoma or autonomic dysfunction. The goal is to better understand what challenges th…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to study immune cells called monocytes and see if they trigger a hormone that raises blood pressure. The goal i…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study looks at whether a personalized brain-training program can improve memory and thinking in older adults (60+) who have high blood pressure but no dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo version for 12 weeks. The …

This study looks at how to best reach adults with uncontrolled high blood pressure who struggle to take their medications as prescribed. Researchers will test different recruitment letters and phone call strategies to see which approach gets more people to attend a counseling ses…

This study looks at how different types of fats in the blood (like cholesterol) are linked to complications in adults with sickle cell disease. Researchers will follow 116 participants from the French Caribbean islands to track their fat levels over time and during acute events l…

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with mild to moderate high blood pressure. Researchers will measure kidney blood flow, artery flexibility, and blood pressure after low- and high-salt diets, as well as after an infusion of a…

This study looks at better ways to check fluid levels in adults with acute kidney injury (AKI). AKI is a sudden drop in kidney function that can be made worse by too little or too much fluid. Researchers will compare different assessment methods, including physical exams and bioi…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study is collecting blood samples from 550 adults with different types of pulmonary hypertension to measure two proteins, Activin-A and FSTL3. Researchers want to see if these proteins can predict who will need a lung transplant or die within two years. The goal is to find a…

This study looks at whether a telehealth program called ECHO can help healthcare teams in New Mexico better care for patients with diabetes and other chronic conditions. The program connects primary care providers with specialists through video sessions for training and case disc…

This study looks at nearly 1,200 people with or at risk for pulmonary hypertension (high blood pressure in the lungs). Researchers use many advanced tests to find new ways to classify the disease and identify biomarkers. The goal is to better understand the disease and improve fu…

This study looks at how the kidneys work differently in people whose blood pressure is sensitive to salt. Researchers will measure kidney oxygen levels and chemical changes in 70 adults with mild high blood pressure after low- and high-salt diets. The goal is to find new ways to …

This study tests a program to help prenatal clinics improve how they measure and treat high blood pressure in pregnant and postpartum patients. About 4,000 clinic staff from North Carolina will receive training, coaching, and practice sessions. Researchers will check if the progr…

This study gives 300 new mothers a medical-grade smartwatch that tracks blood pressure multiple times daily for 6 weeks after delivery. Researchers want to see if daily blood pressure patterns differ between low-risk, intermediate-risk, and high-risk groups. The goal is to better…

This study follows 100 adults aged 35-70 with mildly elevated blood pressure to see how their aldosterone hormone system changes over time. Participants will eat special high-salt or low-salt diets for a few days each year to test how their body responds. The goal is to better un…

This study looks at whether immune cells (monocytes) can be used as a simple test to diagnose salt-sensitive high blood pressure. Researchers will give 20 adults with high blood pressure a high-salt and low-salt diet to see how their blood pressure and immune cells change. The go…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study compares two ways of teaching people with preeclampsia about their condition: a new illustrated app versus standard hospital discharge instructions. About 36 participants will take a quiz to see which method helps them remember key facts and warning signs. The goal is …

This study aimed to see if providing medically tailored meals, lactation support, and food for children could help Black women with hypertensive disorders of pregnancy control their weight after childbirth. The trial was withdrawn before any participants were enrolled, so no resu…

This study tests how drinking 500 ml of water affects blood pressure and heart function in 40 stable heart transplant patients. Researchers will measure changes in blood vessel resistance and blood pressure over 40 minutes. The goal is to understand if water can be a simple way t…

This study will look at 1,000 people living near the University of Milano-Bicocca to understand what factors increase their risk for heart disease. Researchers will examine traditional risks like high blood pressure and diabetes, as well as newer factors like pollution, diet, and…

This observational study follows 350 adults with pulmonary hypertension to see if certain biomarkers in urine and blood are linked to worsening kidney function. Participants undergo standard tests but receive no experimental treatment. The goal is to better understand how kidney …

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study follows over 31,000 middle-aged and older adults to see how being overweight or having high blood pressure affects their risk of heart attacks, strokes, and death. Researchers will track participants until 2026 using routine health checkups. The goal is to better under…

This study was designed to see if training residents of Boston housing developments as Community Health Ambassadors could help more people get primary care visits and screenings for diabetes and high blood pressure. The ambassadors would have led workshops and connected neighbors…

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study looks at whether wearing an activity tracker (like a Fitbit) can better predict how people with pulmonary hypertension will do over 12 weeks compared to the standard 6-minute walk test. About 230 participants will wear the tracker and report how they feel. The goal is …

This study tests whether a simple educational guide can help postpartum patients who had high blood pressure during pregnancy become more active in their own care. Researchers will give the tool to some mothers shortly after delivery and compare their engagement scores with those…

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This study aimed to create a 12-month profile of patients admitted for vascular surgery at University Hospital Limerick in Ireland. The goal was to understand patient characteristics like frailty and other health conditions to improve hospital services and reduce length of stay. …

This study looks at how often children and teenagers (ages 6-18) with type 1 diabetes have pre-hypertension, or early signs of high blood pressure. Researchers will measure blood pressure carefully and also take blood samples to check for related conditions. The goal is to unders…

This pilot study is testing a device called LabClasp that measures blood sugar without needles. Researchers want to see if regular, non-invasive glucose checks can help predict gestational diabetes and preeclampsia in pregnant women. The study plans to enroll 100 women with at le…

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and …

This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for t…