Could a gout drug tame high blood pressure?

NCT ID NCT04916522

Ongoing Disease control Sponsor: Herlev and Gentofte Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether colchicine, a drug used for gout, can improve blood vessel stiffness and heart function in people with high blood pressure. About 150 adults with hypertension and additional risks like diabetes or high cholesterol will take colchicine or a placebo daily for 6 months. Researchers will measure changes in artery stiffness, blood pressure, and heart size.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Colchicine (0.5 mg daily)
What this could lead to: If it works, this could point toward a new way to lower blood pressure and protect the heart in people with hypertension.
What could go wrong: This is a small, early-phase trial, so results may not apply to everyone. Colchicine can cause stomach upset or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder coronary artery disorder endomyocardial fibrosis heart disorder hypertensive disorder Hypertrophy, Left Ventricular Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION

Contacts and locations

Locations

Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev and Gentofte Hospital

Hellerup, 2900, Denmark

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