Endomyocardial fibrosis
MONDO:0006746A disease characterized by fibrotic thickening of the endocardium, particularly the right and/or left inflow tracts. The disease often involves the atrioventricular valves, leading to valvular regurgitaion. It most commonly occurs in children living within 15 degrees of the equator.
Also known as: African endomyocardial fibrosis
22 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Triple drug combo aims to reverse heart scarring in stiff heart failure
Disease control Recruiting nowThis study tests whether a three-drug combination (SGLT2 inhibitor, ARNI, and MRA) can improve heart structure, function, and symptoms in 50 people with advanced HFpEF, a type of heart failure where the heart is stiff but pumps normally. Participants will receive either the tripl…
Phase: PHASE2 • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Gene therapy trial aims to fix heart damage in rare disease
Disease control Recruiting nowThis early-stage trial tests a gene therapy called AAVrh.10hFXN for heart problems caused by Friedreich's ataxia, a rare genetic disease. The therapy delivers a working copy of the frataxin gene to help heart cells function better. 25 people aged 12 to 50 with heart involvement w…
Phase: PHASE1 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New contrast agent could mean lower doses for heart MRI
Diagnosis Recruiting nowThis study tests whether a new MRI contrast agent called Elucirem can detect heart scarring as effectively as the standard agent, but at a much lower dose. Researchers will compare images from 25 adults who previously had a heart MRI with the standard agent. If Elucirem works wel…
Phase: PHASE4 • Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Jun 27, 2026 12:06 UTC
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Heart scans may unlock hidden risks in minority communities
Knowledge-focused Recruiting nowThis study is looking at whether advanced heart imaging, especially cardiac MRI, can help identify the cause of cardiomyopathy and predict risks like death or heart failure in a diverse group of patients. The research focuses on adults in the Bronx, including many from Hispanic a…
Sponsor: Montefiore Medical Center • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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10,000 heart patients join online registry to unlock secrets of cardiomyopathy
Knowledge-focused Recruiting nowThis study is building a large online registry of 10,000 adults with cardiomyopathy or myocarditis, plus those with a strong family history. Researchers will track participants over time to see how many experience serious events like heart failure, dangerous heart rhythms, or dea…
Sponsor: Imperial College London • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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AI could help predict sudden cardiac death in hereditary heart disease patients
Knowledge-focused Recruiting nowThis study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Can we predict who will die suddenly from heart problems?
Knowledge-focused Recruiting nowThis study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Heart tissue analysis aims to unlock better diagnosis
Knowledge-focused Recruiting nowThis study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns in different heart conditions, including after a heart transplant. The goal is to improve how these diseases are diagnosed …
Sponsor: University Hospital, Essen • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Heart MRI breakthrough could spot hidden risks in thousands
Knowledge-focused Recruiting nowThis study is testing whether a detailed heart MRI (called T1 mapping) can better predict who will develop heart disease, heart failure, or long COVID complications. Researchers will scan 6000 adults without known heart disease and follow them over time. The goal is to see if sub…
Sponsor: Johann Wolfgang Goethe University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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New PET scan could reveal hidden heart scarring in real time
Knowledge-focused Recruiting nowThis pilot study is testing a new type of PET/CT scan that uses a radioactive tracer called 68Ga-FAPI to detect active scarring (fibrosis) in the hearts of 30 people with heart failure. The goal is to see if this scan can spot early or ongoing scarring better than current MRI met…
Sponsor: University of Coimbra • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC