Vitamin B2 and folate may prevent pregnancy hypertension in women with gene variant
NCT ID NCT04723836
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking riboflavin (vitamin B2) and a form of folate can prevent high blood pressure in pregnant women who have a specific gene variant (MTHFR TT). About 2250 women in their first trimester are being recruited. Those with the gene variant will receive the vitamins or a placebo from week 16 until delivery. The goal is to see if this personalized nutrition approach can keep blood pressure healthy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Riboflavin (Vitamin B2) and 5-methyltetrahydrofolate (a form of folate)
What this could lead to
If it works, this could offer a simple, non-drug way to prevent high blood pressure during pregnancy for women with a specific gene variant.
What could go wrong
This is a mid-stage trial, so results are not yet proven. The approach only applies to women with a specific gene variant, and the effect on blood pressure may be small.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Letterkenny University Hospital
Letterkenny, Ireland
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Northern Health and Social Care Trust
Coleraine, N.Ireland, BT52 1HS, United Kingdom
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Western Health and Social Care Trust
Londonderry, N.Ireland, BT47 6SB, United Kingdom