Vitamin B2 and folate may prevent pregnancy hypertension in women with gene variant

NCT ID NCT04723836

Ongoing Prevention Sponsor: University of Ulster Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking riboflavin (vitamin B2) and a form of folate can prevent high blood pressure in pregnant women who have a specific gene variant (MTHFR TT). About 2250 women in their first trimester are being recruited. Those with the gene variant will receive the vitamins or a placebo from week 16 until delivery. The goal is to see if this personalized nutrition approach can keep blood pressure healthy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Riboflavin (Vitamin B2) and 5-methyltetrahydrofolate (a form of folate)
What this could lead to: If it works, this could offer a simple, non-drug way to prevent high blood pressure during pregnancy for women with a specific gene variant.
What could go wrong: This is a mid-stage trial, so results are not yet proven. The approach only applies to women with a specific gene variant, and the effect on blood pressure may be small.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder hypertension, pregnancy-induced prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD PRESSURE PREGNANCY

Contacts and locations

Locations

Letterkenny University Hospital

Letterkenny, Ireland
Northern Health and Social Care Trust

Coleraine, N.Ireland, BT52 1HS, United Kingdom
Western Health and Social Care Trust

Londonderry, N.Ireland, BT47 6SB, United Kingdom

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