Can a blood pressure drug reverse heart scarring after aortic repair?
NCT ID NCT06150560
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial tests whether losartan, a common blood pressure medication, can reduce scarring in the heart's main pumping chamber and improve exercise capacity in adults who had surgery to repair coarctation of the aorta. Participants will take losartan, amlodipine, or a placebo daily for a year. The study uses MRI scans and exercise tests to measure changes in heart tissue and fitness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Losartan (an angiotensin-II receptor blocker, also known as Cozaar), compared against amlodipine and placebo
- What this could lead to
- If successful, losartan could become a standard treatment to reduce heart muscle scarring and improve exercise tolerance in people who had coarctation repair, potentially lowering long-term cardiovascular risks.
- What could go wrong
- This is a phase 3 trial, but results are not yet known. The drug may not outperform amlodipine or placebo, and side effects like dizziness, high potassium, or kidney issues are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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