Hypertensive disorder

This early-phase trial tests an experimental antibody called DIAG723 in 93 adults with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. The study will check if the drug is safe and how the body processes it, with…

This study tests a drug called tonlamarsen in adults who were recently hospitalized for dangerously high blood pressure. Participants receive either the drug or a placebo as a shot under the skin every 4 weeks. The goal is to see if tonlamarsen can lower blood pressure and reduce…

This study looks at the long-term safety and effectiveness of the drug QCZ484 in people with high blood pressure. It is for patients who already completed a previous study with the same drug. Researchers will monitor side effects and track blood pressure changes over time.

This early-stage trial is testing a new drug called KK3910 in healthy people and those with high blood pressure. The main goal is to check safety and how the drug moves through the body. It is a small, placebo-controlled study, so it is too soon to know if the drug actually works…

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. About 261 adults with hypertension will either get the real procedure or a sham (fake) one. The goal is to see if this approach safely lowers blood pressu…

This study will give 800 pregnant women biweekly food kits with fruits, vegetables, and other healthy foods to see if it improves their diet and pregnancy outcomes. Participants will be followed from early pregnancy through birth. The goal is to learn whether providing healthy fo…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works…

This phase 2 study tests whether spironolactone, a drug already used for fluid retention, can improve exercise capacity and blood vessel function in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will receive either spironolactone or a placebo for 24 …

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study tests a new drug called RTN-001 in adults whose high blood pressure is not controlled by at least two other medications. About 280 participants will take either RTN-001 or a placebo daily for 12 weeks. The main goal is to see if RTN-001 lowers blood pressure more than …

This study tests an inhaled medicine called L606 for people with high blood pressure in the lungs due to lung disease. About 344 adults will be randomly assigned to receive L606 or a placebo. The main goal is to see if L606 helps them walk farther in six minutes and delays worsen…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better protect the kidneys and heart in 5000 adults with chronic kidney disease and high blood pressure. Participants will receive either the combination or dapagliflozin alone. The stu…

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This long-term study follows people with pulmonary arterial hypertension (PAH) who previously took part in sotatercept trials. Sotatercept is a targeted therapy that aims to stop PAH from getting worse. Researchers will monitor safety, side effects, and how well patients tolerate…

This study tests whether providing money specifically for healthy foods helps pregnant women avoid gaining too much weight. About 1,440 women will either get standard nutrition advice or that plus up to $3,000 for healthy groceries. Researchers will compare weight gain between th…

This study is testing the safety of an inhaled dry powder form of treprostinil (LIQ861) for people with pulmonary hypertension (high blood pressure in the lungs) due to lung disease. About 80 adults will take the drug using a special inhaler, and researchers will monitor for side…

This Phase 2 trial tests a new drug called HDY015, which combines two medicines (QCZ484 and inclisiran) into a single injection. The goal is to see if it can safely lower both blood pressure and cholesterol in people who have both conditions. About 120 adults aged 18-75 with hype…

This study tests whether giving two inhaled drugs (milrinone and epoprostenol) before heart-lung bypass can prevent difficult separation from the machine. About 141 adults having heart surgery will be randomly assigned to receive the drug combo or a placebo. The goal is to see if…

This study tests a procedure called pulmonary artery denervation (PADN) for people who still have high blood pressure in their lung arteries after a mitral valve repair. The procedure uses a catheter to deliver radiofrequency energy to specific nerve points in the main pulmonary …

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This phase 3 trial tests TFC-003, a new eye drop, in 188 adults with primary open-angle glaucoma or ocular hypertension. Participants use the drops twice daily for up to 24 weeks. The main goal is to see if TFC-003 lowers eye pressure better than an active control. The study is c…

This study tests a decision aid—a tool that provides information and goal-setting exercises—to help women who had high blood pressure during pregnancy take steps to protect their heart health after childbirth. The goal is to improve engagement in preventive care like blood pressu…

This study tests a device that uses radiofrequency energy to disrupt nerve signals in the kidney and liver arteries, aiming to lower blood pressure in people with uncontrolled hypertension. About 175 adults aged 18-80 with high blood pressure despite medication will be enrolled. …

This study tests whether doing wall squat exercises for 14 minutes, three times a week, can lower blood pressure and slow the buildup of plaque in arteries. Researchers will compare 100 people doing the squats with 100 people doing gentle stretching, all with high blood pressure.…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This trial investigates whether 16 weeks of yoga—including breathing, postures, relaxation, and meditation—can improve blood pressure, heart health, mental well-being, and thinking skills in adults aged 40 and older with high blood pressure. Participants are randomly assigned to …

This study tests an experimental drug called REGN13335 in 99 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive either the drug or a placebo, on top of their usual PAH medica…

This phase 3 trial tests whether a preservative-free version of bimatoprost eye drops works as well as the standard Lumigan drops for lowering eye pressure. About 600 adults with primary open-angle glaucoma or ocular hypertension in both eyes will receive either the new formulati…

This study tests whether eating only between about 6:30 am and 2:30 pm (an 8-hour window) for 6 days a week can improve blood pressure, blood sugar, and heart rate in adults aged 60 and older with high blood pressure. Participants will follow this pattern for 12 weeks. The goal i…

This study tests a technology-based program to help women aged 18-44 with high blood pressure lower their blood pressure before getting pregnant. Participants will receive support through their primary care clinic and use online tools. The goal is to improve heart health and medi…

This study tests whether different oxygen targets (higher vs. lower) improve outcomes in 39 preterm infants with bronchopulmonary dysplasia and pulmonary hypertension. Each infant will experience both oxygen levels in a crossover design. The goal is to see which level reduces dan…

This study tests whether taking a ketone supplement can prevent the negative effects of eating too much salt, like high blood pressure and kidney strain. Researchers will give 35 healthy young adults either a high-salt diet with a ketone supplement or a placebo, then measure chan…

Most older Americans eat too much salt, which can raise blood pressure and harm the kidneys. This study tests whether a ketone supplement (a substance the body makes during fasting or exercise) can block those harmful effects. Thirty-five adults aged 60-85 will follow a high-salt…

This study tests whether a team of a remote pharmacist, social worker, and nurse, working with patients through a phone app, can help African American and Latinx adults with uncontrolled high blood pressure lower their numbers. Two hundred participants will either get this team-b…

This study tests an experimental drug called SAL0140 in people whose high blood pressure remains high despite current treatments. About 252 adults aged 18-75 with uncontrolled hypertension will receive either the drug or a placebo for 12 weeks. The goal is to see if SAL0140 safel…

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metfo…

This early-stage study tests a new drug called LY3971297 in healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. The main goal is to check for side effects and measure how the drug moves through the body. The study involves up t…

This study tests whether regular phone calls and text messages with lifestyle advice can help adults in Nepal with uncontrolled high blood pressure lower their numbers. Five hundred participants will receive either the mobile health program or usual care for six months. The goal …

This study offers continued access to the inhaled drug TPIP for people with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (PH-ILD) who have already completed a related study. Participants must have successfully finished prior …

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This phase 3 trial is testing whether a once-daily inhaled medication called treprostinil palmitil can help adults with pulmonary arterial hypertension (PAH) walk farther. About 344 participants will receive either the drug or a placebo for 24 weeks. The main goal is to see if th…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This phase 3 study is testing an injectable drug called zilebesiran in about 11,000 adults whose high blood pressure is not well controlled despite taking at least two standard medications. Participants also have heart disease or are at high risk for it. The goal is to see if add…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study tests a single dose of an experimental drug called ALN-AGT01 in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely helps control blood pressure by measuring changes in blood pre…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This study tests whether a combination of nifedipine and enalapril controls high blood pressure after childbirth better than nifedipine and labetalol. It involves 200 postpartum women with persistent hypertension. The goal is to reduce hospital stays, readmissions, and severe blo…

This study tests a health coaching program called STAR-MAP to help older adults (age 40+) with high blood pressure take their medication regularly. About 402 participants with uncontrolled blood pressure and low medication adherence will be recruited through a Louisiana health in…

This study compares two treatments for a condition called primary aldosteronism, where a small adrenal gland tumor causes high blood pressure. One treatment is laparoscopic surgery to remove the tumor; the other is radiofrequency ablation (RFA), which uses heat delivered through …

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This study tests whether a program called BETTER can help pregnant women have healthier births. The program includes a one-on-one coaching session and regular text messages to help women connect with resources for housing, food, and transportation. Researchers will compare outcom…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study follows 280 adults and children with pulmonary hypertension who are already taking macitentan or selexipag in a previous trial. The goal is to monitor long-term safety, including side effects and serious events, while allowing continued access to the medication. Partic…

This study tests whether implanted monitors can quickly show if a new PAH drug is working. About 40 adults with stable PAH will try two different approved drug plans while their heart and lung function are tracked. The goal is to see if this approach can help doctors choose the b…

This study compares two common blood pressure medications, labetalol and nifedipine, in 110 new mothers with postpartum hypertension. The goal is to see which drug controls blood pressure better and reduces the need for ongoing medication beyond six weeks after delivery. Particip…

This study looks at whether giving older adults with high blood pressure practical advice and air cleaners can reduce their exposure to heat and air pollution. About 100 people aged 65 and older from Barcelona and Nicosia will take part. They will wear sensors to track temperatur…

This phase 1 trial tests the safety of a new drug called ZMA001 in 96 healthy adults. ZMA001 is a monoclonal antibody designed to reduce lung damage in pulmonary arterial hypertension (PAH), a serious condition. Participants receive a single dose of the drug or placebo and are mo…

This study is tracking 3000 people with high blood pressure who have been treated with the Paradise Ultrasound Renal Denervation System, a device that uses ultrasound to calm overactive kidney nerves. The goal is to see how safe and effective the treatment is over many years by m…

This study tests whether the drug sotatercept can improve how well the lungs transfer oxygen in people with pulmonary arterial hypertension (PAH). Twenty-seven adults with PAH will receive the drug every 21 days for 29 weeks and undergo lung function tests, heart ultrasounds, and…

This Phase 3 trial tests whether the drug HRS-7535 can lower blood pressure better than a placebo in 648 adults with hypertension who are also overweight or obese. Participants will take the drug or placebo for up to 48 weeks, and researchers will measure changes in blood pressur…

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study tests whether a travoprost drug implant (iDose TR) plus a tiny stent (iStent infinite) can lower eye pressure better than the implant alone in people with open-angle glaucoma or high eye pressure. About 150 adults will receive either the combo or a sham procedure and b…

This study tests whether Yufeng Ningxin, a traditional Chinese medicine, can safely lower blood pressure in adults with mild hypertension. About 350 people aged 18-65 with untreated or washed-out high blood pressure will receive either the herbal tablet or a placebo for 8 weeks. …

This study enrolls 864 Black adults with uncontrolled high blood pressure to see if a home monitoring program with pharmacist and community health worker support works better than usual clinic care. Participants will either get a home BP monitor plus remote medication management …

This study tests whether taking equol, a compound from soy, for 12 weeks can improve blood vessel function in postmenopausal women with moderate chronic kidney disease (stages 3-4). The goal is to lower their high risk of heart disease. Researchers will measure changes in artery …

This study tests whether a program to improve sleep can help lower blood pressure in adults. Two hundred people with high blood pressure and poor sleep will either get standard heart health advice or a sleep improvement program with coaching and tips. The goal is to see if better…

This study tests an experimental oral drug called ROC-101 in 40 adults with pulmonary arterial hypertension (PAH) or pulmonary hypertension linked to interstitial lung disease (ILD-PH). Participants take the drug alongside their standard care for 24 weeks, with a long-term follow…

This study is testing a community-based program that uses exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. The goal is to improve heart and lung function and overall disease control. The program will enroll 10…

This phase 3 trial tests an inhaled drug called treprostinil palmitil in 344 adults with pulmonary hypertension caused by interstitial lung disease. Participants take the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them walk farther in six…

This study tests a special pacemaker setting designed to lower blood pressure in people with hypertension. About 500 adults who already have or need a pacemaker will take part. The goal is to see if this new setting safely reduces average blood pressure over 24 hours, compared to…

This Phase 3 trial tests a drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese. Participants receive weekly injections of either the drug or a placebo for 48 weeks. The main goal is to see if IBI362 lowers blood pressure more th…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study tests whether a supplement called 2-HOBA can help people with lupus by lowering blood pressure and reducing harmful immune activity. About 42 women with stable lupus and mild-to-moderate high blood pressure will take either 2-HOBA or a placebo for 8 weeks, then switch.…

This study compares two mobile health strategies for managing high blood pressure after pregnancy. 770 new mothers with pregnancy-induced hypertension will use either a 12-week or 10-day text-based blood pressure monitoring program. The goal is to see which approach better lowers…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This study tests whether adding Qishen Yiqi Dropping Pills, a Chinese herbal medicine, to standard therapy can improve exercise ability and quality of life in 120 adults with severe pulmonary hypertension. Participants will be randomly assigned to receive either the herbal pills …

This early-phase study aims to see if a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a placebo infusion, and researchers…

This study is testing whether a year-long program of daily blueberries, protein powder, and three weekly exercise sessions can reduce frailty and lower the risk of heart disease in older adults. Researchers will enroll 240 people aged 65 and older in Nova Scotia. The goal is to s…

This study looks at whether royal jelly, a substance made by bees, can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will give 34 participants royal jelly or a placebo for two months and measure changes in blood markers. The goal is to s…

This study is testing a new medicine called PF-07868489 for people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lung arteries makes the heart work harder. The study is open-label, meaning everyone knows they are getting the drug, and it…

This study tests whether taking propolis and royal jelly supplements for two months can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will measure inflammatory markers in blood samples from 48 participants. The goal is to see if these na…

This study tests whether adding dapagliflozin to baxdrostat reduces protein in the urine (a sign of kidney damage) better than baxdrostat alone. About 218 adults with chronic kidney disease and high blood pressure will take either the combo or baxdrostat plus a placebo. The goal …

This study tests an investigational drug called IMC-003 in 120 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants receive multiple injections of the drug or a placebo, alongside their usual treatments. The go…

This early-stage trial tests a single injection of CBP-4888 in 60 pregnant women hospitalized with preterm preeclampsia, a serious condition involving high blood pressure and organ stress. The goal is to find a safe dose and see if the drug can lower a harmful protein called sFlt…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study compares starting with two oral medications (tadalafil and ambrisentan) versus one medication alone in people newly diagnosed with pulmonary arterial hypertension (PAH) who also have at least two heart-related conditions. The goal is to see if the two-drug approach lea…

This study is testing whether taking green propolis extract and royal jelly together can reduce inflammation and oxidative stress in people with high blood pressure or chronic kidney disease. Over two months, 153 participants will take capsules of the supplements or a placebo. Re…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests an experimental drug called IKT-001 in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. About 486 adults will receive either IKT-001 or a placebo to see if the drug improves b…

This Phase 2 trial tests an experimental drug called APL-9796 in 48 adults with pulmonary hypertension (high blood pressure in the lungs). The study aims to see if the drug is safe, tolerable, and effective. Participants receive injections under the skin, and researchers monitor …

This study tests if the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. Researche…

This study is tracking 1,000 patients with high blood pressure who receive the Paradise Ultrasound Renal Denervation treatment. The procedure uses ultrasound energy to calm overactive nerves near the kidneys, which can help lower blood pressure. Researchers are monitoring blood p…

This study looks at whether adding a slow breathing technique (coherent breathing) to aerobic exercise improves heart and lung health and quality of life more than exercise alone. Forty adults with stage 1 high blood pressure will take part in a 4-week program. Researchers will m…

This study tests whether taking a daily low-dose aspirin for six months after childbirth can improve heart function in women who had preeclampsia. Preeclampsia can raise a protein called Activin A, which may harm the heart. The trial will compare aspirin to a placebo in 180 women…

This study is testing whether valsartan, a drug already used for high blood pressure, can help people with pulmonary arterial hypertension (PAH). Researchers will give 60 adults either valsartan or a placebo for 24 weeks to see if it improves how far they can walk in six minutes …

This early-phase study tests whether an oral supplement called L-Citrulline is safe for preterm babies born at or before 30 weeks who have lung problems (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of a natural substance in the blood can reduce…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This pilot study is testing whether providing free produce boxes and nutrition education can improve health outcomes for Veterans with kidney disease and food insecurity. The study will enroll 20 participants and measure changes in blood pressure and kidney function. Researchers …

This study compares two FDA-approved laser treatments for open-angle glaucoma: the standard SLT and a newer, non-contact version called DSLT. Both aim to lower eye pressure and prevent vision loss. About 172 adults with glaucoma or high eye pressure will be randomly assigned to o…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study tests whether adding a 10-week health coaching program from a community health worker to remote blood pressure monitoring helps women who had high blood pressure during pregnancy. 240 women will be followed for 6 months after delivery. The goal is to see if the combine…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study is testing whether providing information about local food resources, help from a community health worker, or medically-tailored meals can improve blood pressure and medication adherence in people with uncontrolled hypertension who also face food insecurity. About 224 p…

This study looks at whether two types of strength training (dynamic and isometric) can improve heart health, mental well-being, and physical fitness in adults aged 60 and older who have high blood pressure. Sixty participants will be randomly assigned to one of the two exercise p…

This pilot study is testing whether giving progesterone (17 OHPC) to pregnant women diagnosed with preeclampsia before 34 weeks can improve outcomes for both mother and baby. The study will enroll 60 participants at the University of Mississippi Medical Center. Researchers will m…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm, skin, and placenta to see if MitoQ helps restore normal function and pr…

This study tests whether a combination eye drop (Rocklatan) works better than a standard drop (Latanoprost) at lowering eye pressure over a full 24-hour period in adults with open-angle glaucoma or ocular hypertension. About 30 participants will use one drop in each eye nightly. …

This study tests a new wearable device that measures blood pressure without a cuff, called CART BP Pro, to help manage high blood pressure in Korean adults whose condition is not well controlled by current medications. About 400 participants will either use the device to guide th…

This study tests a structured behavioral program called the BMW Toolkit for pregnant women with both gestational diabetes and pregnancy-induced hypertension. The toolkit includes diet, exercise, sleep, and self-care guidance delivered over 7-8 sessions. Researchers will compare b…

This study is testing a new educational tool called the Decreased Salt High Potassium (DSHP) Tool, designed to help adults with high blood pressure reduce their salt intake and eat more potassium-rich foods. About 190 participants from two clinics in Singapore will either receive…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests an experimental drug called LTP001 for pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard for the heart to pump blood. The trial has two parts: first, healthy volunteers receive single or multiple doses to check safety and how the …

This study tests whether a new combination drug works better than taking two separate medicines for people with both high blood pressure and type 2 diabetes. About 228 adults will take either the combo pill or a single-ingredient pill for 12 weeks. Researchers will check changes …

This Phase 2 trial tests ravulizumab (Ultomiris) in 14 pregnant individuals with severe preeclampsia or HELLP syndrome before 34 weeks of pregnancy. The drug aims to block part of the immune system that may drive these dangerous conditions. Researchers will measure blood markers …

This study looks at whether a special form of folic acid (5-MTHF) can improve blood vessel health in pregnant women with high blood pressure or pre-eclampsia. Researchers will measure key molecules in the blood, placenta, and umbilical cord to see if the supplement helps. The tri…

This registry follows 5,000 people with high blood pressure who undergo a procedure called renal denervation. The procedure uses a catheter to deliver radiofrequency energy to nerves in the kidney arteries, which may help lower blood pressure. Participants are tracked for up to 5…

This study is testing a 20-week exercise program that combines endurance and resistance training in postmenopausal women with or without high blood pressure. Researchers want to see which mix of exercises best improves heart health, body composition, and quality of life. Sixty ph…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This phase 2 trial tests a radioactive drug called Lu-177-DOTATATE in 130 adults with rare adrenal or neck tumors that cannot be surgically removed. The drug is given four times over about 8 months, and researchers track how long the cancer stays under control. The goal is to see…

This early-stage trial tests whether draining fluid from the spine (external lumbar drainage) is safe and doable for people with severe traumatic brain injury who have high pressure inside the skull. Thirty adults aged 18-65 will receive either standard care alone or standard car…

This early-stage study is testing whether artesunate, a drug used for malaria, is safe for people with pulmonary arterial hypertension (PAH). Fifteen adults with PAH will take increasing doses of artesunate capsules for 20 weeks. The main goal is to check for side effects, not ye…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by lung scarring. The goal is to see if the combination is safe and tolerable. About 20 adults with this condition will particip…

This pilot study tests a 12-week community-based program to help adults with uncontrolled high blood pressure. A team including a pharmacist, nurse, and community health workers provides medication management, monitoring, and education in local settings. The goal is to see if thi…

This study tracks 1,000 Medicare patients with uncontrolled high blood pressure to see if a procedure called renal denervation (using the Symplicity Spyral device) helps lower blood pressure and prevent heart attacks or strokes over two years. Researchers will compare patients wh…

This study tests whether a procedure to open narrowed kidney arteries (renal artery stenting) helps high-risk patients with resistant high blood pressure, declining kidney function, or heart failure. About 80 participants will either receive the real procedure or a sham procedure…

This study tests a drug called sotatercept in 42 children aged 1 to 18 who have pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. The drug is given as a shot every 3 weeks, and the main goal is to see if it is safe and how the bod…

This study tests whether a natural substance called inorganic nitrate can safely lower blood pressure in pregnant women with chronic hypertension. About 144 women will receive either nitrate or a placebo from the second trimester onward. The goal is to see if nitrate reduces the …

This study looks at whether community health workers can help emergency department patients with high blood pressure connect to local resources that address their social needs, like food or housing. Fifteen adults with uncontrolled hypertension will complete surveys and receive r…

This study tests whether a quick laser treatment called DSLT can help people with glaucoma or high eye pressure use fewer daily eye drops. Sixty adults whose eye pressure is already controlled with 1-3 types of drops will receive the laser in one or both eyes. Researchers will ch…

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This study looks at whether adding Pilates breathing or diaphragmatic breathing to moderate cycling can improve blood pressure, chest expansion, lung function, and quality of life in people with hypertension. 45 adults aged 20–55 with stage 1 or 2 high blood pressure will be spli…

This study tests whether adding sleep health coaching to a diet and exercise program can improve heart health, especially blood pressure. About 150 adults with high blood pressure from underserved NYC neighborhoods will take part. The program includes sleep education, a Fitbit tr…

This study compares two fluids—sodium lactate and a concentrated saline solution—in 40 adults with septic shock. The goal is to see which one better supports blood flow and acid balance. Participants will receive either fluid in a double-blind setup, and researchers will measure …

This study tests whether showing smokers graphic health warnings (like pictures of diseased lungs) along with personalized advice from a pharmacist can help them quit. About 3,400 adult smokers in Bangladesh and Pakistan will be split into three groups: one gets only the warning …

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests whether combining pharmacist advice with help from community health workers can improve blood pressure control in African American adults aged 55 and older. Participants will receive support for 24 months to help them take their medications and make healthier lif…

This study tests whether beetroot powder, which is rich in nitrates, can help lower blood pressure in people with resistant hypertension (high blood pressure that doesn't respond well to standard medications). Researchers will monitor blood pressure changes in 50 participants ove…

This study compares a wearable blood pressure monitor (Aktiia G1) to a traditional arm cuff in adults with uncontrolled high blood pressure. Over 6 months, researchers will see which method leads to better blood pressure control. Participants must have a smartphone and attend two…

This study tests whether eating grape powder daily for 3 weeks can improve gut health, reduce inflammation, and improve blood vessel function in 40 overweight adults aged 45-70. Participants will drink grape or placebo powder twice a day and provide blood and stool samples. The g…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This study tests whether treating mild high blood pressure (stage 1 hypertension) during pregnancy can improve baby birth weight. 74 pregnant people with blood pressure between 130-139/80-89 mmHg will be randomly assigned to either active treatment with blood pressure medication …

This observational study will follow 12,000 Korean adults with stage 1 hypertension who are newly prescribed OLMETEC or OLMETEC Plus. The main goal is to see how well the medication controls blood pressure over 24 hours, especially at night. Participants will have their blood pre…

This study tests whether a non-invasive technique called remote ischemic preconditioning (RIPC) can help lower blood pressure in people with mild hypertension. RIPC involves briefly restricting blood flow to an arm using a cuff, which may trigger protective effects. Researchers w…

This study compares two blood pressure medications, eplerenone and chlorthalidone, in 75 adults with high blood pressure and thickened heart muscle. Researchers want to see if eplerenone improves blood flow to the heart and how efficiently the heart uses oxygen. Participants will…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests whether adding macitentan to the standard drug dapagliflozin improves outcomes for people with heart failure and a specific type of high blood pressure in the lungs. 64 adults in South Korea will take either the combo or dapagliflozin alone for 24 weeks. Research…

This study tests whether spironolactone, a blood pressure pill, can help women who had high blood pressure during pregnancy avoid long-term heart issues. About 200 women with overweight and recent hypertensive pregnancy will take the drug or a placebo daily for 12 weeks after del…

This study tests a program that combines online education, a medication reminder app, and a home blood pressure monitor to help African American adults aged 50+ better manage their hypertension. Participants use these tools for 6 months while continuing their regular care. The go…

This study tests a new preservative-free eye drop combination (QLS-111-FDC) to lower eye pressure in people with open-angle glaucoma or ocular hypertension. About 60 adults with mild to moderate disease will receive the treatment. The goal is to see if it safely reduces eye press…

This study tests a home blood pressure monitoring program for 1,200 women in Nigeria who had high blood pressure during pregnancy. The program includes patient education, home BP monitors, follow-up care, and free medication if needed. Researchers want to see if this approach lea…

This Phase 3 trial tests a second-generation implant placed inside the eye that slowly releases travoprost, a drug that lowers eye pressure. The study will enroll 510 adults with open-angle glaucoma or high eye pressure. The goal is to see if the implant is safe and effective at …

This early-stage study tests a new way to use a heart-lung machine (ECMO) in 4 people waiting for a lung transplant who also have heart failure from high blood pressure in the lungs. The goal is to see if this approach can keep them alive and stable until they receive a transplan…

This early study tests a new medicine called SC101, given as a single injection around the kidneys, for people with resistant high blood pressure and moderate to severe chronic kidney disease. The main goal is to check safety, with only 3 participants. Researchers will also monit…

This study tests a device called the Alma system for women who have severe bleeding after childbirth that does not stop with standard treatments. About 50 women who experience heavy bleeding after vaginal or C-section delivery will be enrolled. If usual care fails, the Alma syste…

This study tests an experimental drug called TX000045 in 180 adults with pulmonary hypertension (high blood pressure in the lungs) caused by a type of heart failure where the heart pumps normally but doesn't relax properly. Participants will receive either the drug or a placebo f…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This study looks at whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to fresh groceries. About 80 participants from Baltimore will be randomly assigned to receive either standa…

This Yale study tests two ways to help people with high blood pressure: a remote monitoring program alone, or that program plus a community health worker who helps with home monitoring, appointments, and social needs like food or housing. 1,440 participants with elevated blood pr…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a cloud-connected blood pressure monitoring program for new mothers with high blood pressure disorders. The goal is to see if remote monitoring helps more women track their blood pressure after giving birth and reduces hospital readmissions. About 540 pregnant an…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This early-stage study tests whether empagliflozin, a drug used for diabetes, can help people with pulmonary arterial hypertension (PAH). About 72 adults will take either the drug or a placebo daily for 12 weeks. Researchers will check if it lowers lung blood pressure and improve…

This study tests whether coaching and support from community health workers, delivered by phone or video, can help people with dangerously high blood pressure avoid serious heart problems. Over 3,600 adults who came to the emergency room with very high blood pressure will be rand…

This study compares two telehealth programs designed to help new mothers get faster care after childbirth, especially those with low income. About 3,500 women will receive either virtual education with reminders or a more interactive telehealth model. The goal is to see which app…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests whether a smartphone app that offers small cash rewards for daily pill photos can help people with high blood pressure stick to their medication. Six hundred participants will either get the app with rewards, the app plus a personal action plan, or standard care.…

This study tests a program designed to help people with high blood pressure and high cholesterol lower their risk of heart disease. About 1,980 adults from Penn Medicine primary care clinics in West/Southwest Philadelphia and Lancaster will take part. The program uses tools and b…

This study tests whether sildenafil (the drug in Viagra) can help people with severe lung high blood pressure caused by long-term rheumatic heart valve disease. Researchers will give 100 participants either sildenafil or a placebo three times daily for six weeks. The main goal is…

This Phase 3 trial compares two treatments for people with high blood pressure and chronic kidney disease: finerenone versus a fixed-dose combination of torsemide and spironolactone. The study will enroll 30 adults to see which approach better lowers blood pressure, reduces prote…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This study tests whether extra guidance from a pharmacist can help people with pulmonary arterial hypertension (PAH) use their inhaled iloprost correctly and consistently. PAH is a rare, serious lung condition that makes it hard to breathe. The trial will enroll 72 adults who alr…

This study tests a new way to program pacemakers to help lower blood pressure in people who have both high blood pressure and a slow heart rate. About 30 adults who already have or need a special pacemaker will try two different setup sessions. Researchers will check if the new s…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This study tests whether the drug Isturisa can improve blood sugar, cholesterol, blood pressure, weight, and bone strength in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Ten adults with MACS will take Isturisa for two…

This study tests whether a daily pill called engagliflozin (a type of SGLT2 inhibitor) can improve heart function in people who have high blood pressure and early signs of heart failure but do not have diabetes. About 120 adults will receive either the drug or a placebo for 6 mon…

This study tests whether the antibiotic minocycline can lower blood pressure in people whose hypertension does not respond to standard treatments. Researchers will give 120 adults either minocycline or a placebo daily for three months to see if the drug works by changing gut bact…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This study is for people with idiopathic intracranial hypertension (IIH) who have been on the drug acetazolamide for over a year without enough relief. It tests whether placing a small stent in a narrowed brain vein can lower the pressure and improve symptoms like headache and vi…

This study tests if dapagliflozin, a diabetes drug, can reduce heart and blood vessel risks in women who had high blood pressure during pregnancy. About 200 participants will take either the drug or a placebo daily for six months after delivery. The goal is to see if the drug imp…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 610 participants will receive either the implant, timolol eye drops, a sham procedure, or placebo drops. The main goal …

This study tests a redesigned inserter for the travoprost implant, a tiny device placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 30 adults will receive the implant using the updated inserter. The main goal is to see if doct…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests whether a smartphone app called FAITH! can help African-American adults with uncontrolled high blood pressure lower their numbers and improve heart-healthy habits. About 100 participants will use the app or receive standard care, and their blood pressure and self…

This study tests a program where trained peers deliver blood pressure medications directly to patients' homes and use health technology to support adherence. The goal is to see if this approach helps people with uncontrolled high blood pressure take their pills regularly and lowe…

This study tests whether iloperidone, a drug already used for schizophrenia, can help lower blood pressure in people whose hypertension is not controlled by their current medications. About 240 adults will receive either iloperidone or a placebo for 4 weeks, and researchers will …

This study tests whether a daily dose of pravastatin, a common heart medication, can safely prolong pregnancy in women diagnosed with severe early-onset preeclampsia or fetal growth restriction. The trial will include 154 pregnant women between 24 and 30 weeks of gestation, rando…

This study tests whether an artificial intelligence (AI) tool that analyzes a simple ECG can help doctors find undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be random…

This study is testing whether a digital stethoscope, combined with artificial intelligence, can detect two serious conditions: high blood pressure in the lungs (pulmonary hypertension) and a weak heart pump (low ejection fraction). About 3,850 adults will have their heart sounds …

This study is testing whether a digital stethoscope and a simple heart monitor (ECG) can detect pulmonary hypertension, a serious condition where blood pressure in the lungs is too high. About 1,500 adults who are already scheduled for heart tests will have their heart sounds and…

This study is testing whether a special digital stethoscope, combined with artificial intelligence, can detect pulmonary hypertension (high blood pressure in the lungs) by listening to heart sounds and recording a single-lead ECG. Researchers will enroll over 2,400 adults who are…

This study aims to improve early detection of preeclampsia, a dangerous pregnancy condition. Researchers will collect blood samples from over 6,500 pregnant women between 11-14 weeks of pregnancy and compare the results with pregnancy outcomes. The goal is to see how well a new b…

This study tests a wearable ring that measures blood pressure, comparing it to the standard 24-hour monitor in 100 people with heart failure and reduced pumping ability. The goal is to see if the ring is accurate and easy to use. If successful, it could make blood pressure tracki…

This study tests whether the Withings BPM Pro 2, an automatic blood pressure cuff, gives accurate readings for pregnant women, including those with high blood pressure or pre-eclampsia. About 45 participants will have their blood pressure measured with both the device and a stand…

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

This study is testing a new blood test called the MaiRa Preeclampsia Test to see if it can accurately predict preeclampsia early in pregnancy. Preeclampsia is a serious condition that can harm both mother and baby. The test looks at genetic material in the mother's blood to ident…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study tests a new smart contact lens that measures eye pressure continuously for 24 hours, compared to standard spot checks. It involves 12 adults with glaucoma or high eye pressure. The goal is to see if the lens provides accurate readings day and night, which could lead to…

This study tests a new steroid-based blood test to see if it can more accurately diagnose primary aldosteronism—a common, treatable cause of high blood pressure—in people who are already taking blood pressure medications. Current tests often require patients to temporarily stop o…

This study looks at whether a brain wave monitor (BIS) and two blood tests (sFIT/PIGF ratio and adrenomedullin) can more accurately grade the severity of preeclampsia and eclampsia in pregnant women. Researchers will enroll 48 participants to see if these tools can predict risk b…

This study will test if the Oura Ring can identify signs of high blood pressure using a new algorithm. Researchers will compare the ring's readings to what participants report about their own blood pressure. Up to 2 million adults in the US who already use an Oura Ring will take …

This study is testing a wrist-worn device that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings to standard blood pressure measurements in 355 adults over four weeks. The goal is to see if this optical method is accurate e…

This study looks for early signs of pulmonary hypertension (high blood pressure in the lungs) in people with chronic lung diseases like COPD or pulmonary fibrosis. Researchers will analyze collagen fragments in blood and lung tissue to create a 'fingerprint' that could lead to si…

This study explores whether a smartphone can reliably screen for high blood pressure by analyzing video recorded at your fingertip. About 100 adults will record their blood pressure using both a smartphone and a standard arm cuff, three times each morning and evening for a week. …

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study tests whether a non-invasive device called electrical impedance tomography (EIT) can accurately diagnose pulmonary hypertension, a serious lung condition. Currently, diagnosis requires an invasive procedure called right heart catheterization. Researchers will compare E…

This study compares two new investigational devices for measuring eye pressure against the current standard methods in 200 adults with glaucoma or suspected glaucoma. The goal is to find a more objective, reproducible, and portable way to measure eye pressure. Participants will h…

This study tests a wrist-worn device called ViTrack that measures blood pressure continuously without needles. Researchers will compare its readings to standard invasive monitoring in 40 adults having noncardiac surgery. The goal is to see if the device can accurately track blood…

This study tests whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) can detect pulmonary hypertension—a serious condition where blood pressure in the lungs is dangerously high—in people aged 50 to 85 who are at risk. Over 8,600 participants will get the AI-ECG…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study compares two different doses of vitamin D3 supplements in pregnant women who have low vitamin D levels. The goal is to see if a higher dose (50,000 IU every two weeks) is better than a lower dose (5,000 IU weekly) at preventing preeclampsia, a serious pregnancy complic…

This study tests whether taking 150 mg of aspirin daily, starting before 20 weeks of pregnancy, can prevent serious problems like preeclampsia, poor fetal growth, placental abruption, preterm birth, and death in pregnant women with chronic high blood pressure. About 500 women wil…

This study tests whether giving HIV prevention pills (PrEP) to people right in the emergency room helps them start and stay on prevention. Researchers will enroll 250 HIV-negative adults at risk for HIV in Dallas. Participants get a 30-day pill supply and a clinic appointment to …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This study tests an online program called UPDOs Protective Styles to help Black women in the southeastern US learn about and start using PrEP, a medicine that prevents HIV. Researchers will recruit 1000 participants from 32 beauty salons in areas with high HIV rates. One group wi…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests whether taking a daily low-dose aspirin (150 mg) starting early in pregnancy can prevent preterm preeclampsia in first-time mothers who became pregnant through assisted reproductive technology (ART) like IVF. About 1,164 women will be randomly assigned to receive…

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) in pregnant women at risk. Over 10,000 participants will be assigned to one of the two doses early in pregnancy. The goa…

This study tests whether regularly warming the legs with a portable sauna blanket can improve blood vessel health and lower the risk of high blood pressure disorders in pregnant women with obesity. About 118 women will use the blanket at home for 16 weeks, starting early in pregn…

This study looks at whether natural salicylates found in foods like fruits and vegetables can help prevent preeclampsia, a dangerous pregnancy condition. Researchers will track the diets of 500 pregnant women and measure salicylate levels in their blood and urine. The goal is to …

This study is testing whether a simple screening test in early pregnancy (around 11-14 weeks) can predict and help prevent preeclampsia, a dangerous condition involving high blood pressure. The trial will involve 14,500 pregnant women and aims to reduce severe complications like …

This study tests a program to help Black women in Baltimore start taking PrEP, a medication that prevents HIV. The program addresses challenges like intimate partner violence and racism that can make it hard to get PrEP. About 300 Black women who are HIV-negative and at risk will…

This study aims to see if a new screening program during the first trimester can better identify pregnant women at risk for preeclampsia—a condition causing high blood pressure that can harm both mother and baby. Up to 80,000 women in Denmark will take part. Those found to be hig…

This study tests whether personalized telehealth coaching from a pharmacist can help people adopt preventive health strategies like better nutrition, exercise, and medication use. Researchers will enroll 360 adults from industries like healthcare and food service in Louisiana. Pa…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This study is testing a smartphone app called MedlyPeds that lets children with heart disease send their weight, blood pressure, and heart rate to their doctors from home. The app also asks about symptoms and sends personalized tips. The goal is to see if the app is easy to use a…

This study is testing a mobile health app called Moms@Home to help pregnant women with high blood pressure monitor their readings at home. About 100 women with gestational or chronic hypertension will use the app and share their home blood pressure data. The goal is to see if the…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study compares virtual reality (VR) relaxation with face-to-face relaxation for pregnant women hospitalized with preeclampsia, a condition causing high blood pressure. Researchers will measure anxiety, comfort, heart rate, and baby's well-being in 96 participants. The goal i…

This study looks at whether drinking beetroot juice every day for 12 weeks can help postmenopausal women get more heart and blood vessel benefits from exercise. The researchers will compare two groups of women doing the same exercise program—one group gets real beetroot juice, th…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether a simple handgrip exercise can safely lower blood pressure and improve thinking skills in pregnant women with and without chronic hypertension. Thirty pregnant women will either perform short handgrip squeezes or rest quietly, and researchers will measure…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study tests whether a 12-week home-based exercise program, started soon after diagnosis, improves walking distance and quality of life in people with pulmonary hypertension. Forty participants will either exercise early or wait six months. The goal is to see if exercise plus…

This study tests whether diaphragmatic breathing exercises can reduce heart rate, blood pressure, and dizziness in pregnant women with Postural Orthostatic Tachycardia Syndrome (POTS). 44 pregnant women will be split into two groups: one doing breathing exercises, the other recei…

This study has two parts. First, it looks at genes that might be linked to high blood pressure in Thai people. Second, it tests whether a specific breathing pattern called 4-7-8 (inhale for 4 seconds, hold for 7, exhale for 8) can help lower blood pressure. About 200 adults with …

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether doing very short wall-squats (just a few minutes) at four different times each day can lower blood pressure in people with hypertension or pre-hypertension. Researchers will compare this approach to doing all the squats at once. The goal is to find a simp…

This study tests whether supervised exercise sessions done at home through video calls can improve breathing, fatigue, and quality of life in people with elevated pulmonary artery pressure. Twelve adults with stable symptoms will be randomly assigned to either telerehabilitation …

This study tests whether a 16-week home exercise program, guided by a smartwatch, can help children aged 8-18 with pulmonary hypertension become more active and improve their muscle strength and quality of life. Participants will wear activity trackers and follow a personalized e…

This pilot study tests whether semaglutide (Ozempic), a drug used for diabetes and obesity, is safe and tolerable for weight loss in people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take weekly injections for 12 weeks. Res…

This study looks at whether a laser treatment called DSLT can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. Researchers will measure eye pressure at three times during one day before the laser and again six months after. The goal is …

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This study tests an 8-week group mindfulness program designed for African American adults who have both high blood pressure and depression. Researchers want to see if the program improves mood and blood pressure, and if it works well in a community setting. Participants will lear…

This study tests whether a non-invasive physiotherapy technique that stimulates the vagus nerve can help lower blood pressure in pregnant women with preeclampsia. About 210 women will receive either standard blood pressure medication alone or medication plus this gentle therapy. …

This study tests whether a medication given as a nose spray (dexmedetomidine) can keep blood pressure stable in elderly patients with high blood pressure who are having cataract surgery. About 126 people aged 65 and older will take part. The goal is to see if the spray reduces da…

This study looks at whether using a CPAP machine (a device that gently blows air through a mask) can safely lower high blood pressure when lying down at night and help reduce dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like…

This study tests whether a mobile health program can help adolescents with pulmonary arterial hypertension increase their daily step counts. About 50 teens aged 10-21 will use a Fitbit and receive coaching to boost activity over 12 weeks. The goal is to improve exercise and quali…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study looks at whether Street Racket, a simple racket sport, can be added to standard pulmonary rehabilitation for people with chronic lung disease. Twelve participants will play Street Racket every two weeks during their rehab program. Researchers will measure how acceptabl…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study is testing whether a beetroot extract supplement can lower blood pressure and improve muscle oxygen levels in older women (ages 60-70) with high blood pressure during a single aerobic exercise session. Twenty participants will take either the beetroot supplement or a p…

This study is testing whether an 8-week telephone-based mindfulness program (MIND-BP) can help Black women with high blood pressure lower their blood pressure and reduce stress. The study will compare the mindfulness program to a general support group (BOOST). 300 Black women fro…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This natural history study follows 270 adults with pulmonary arterial hypertension (PAH) and healthy volunteers to track how the disease changes over time. Researchers will use blood tests, heart and lung imaging, and a six-minute walk test to find new markers of disease severity…

This study compares two eye drop treatments—latanoprost alone versus a combination of netarsudil and latanoprost (Rocklatan)—to see if the combination improves blood flow in the veins around the eye. Researchers will use special imaging techniques to measure blood flow in adults …

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study follows up to 3,500 people with sickle cell disease to learn more about how the condition progresses and what complications arise. Participants receive their usual medical care outside the hospital and visit the clinic for check-ups and research tests. No experimental …

This study is testing a new non-invasive blood pressure device that uses a cuff and special algorithm to measure blood pressure. Researchers will compare its readings to those from an arterial line, which is the most accurate method but requires a needle in an artery. The study i…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at whether home blood pressure readings can correctly identify different types of high blood pressure (like masked or white coat hypertension) in children aged 6 to 18. Researchers will compare home measurements to 24-hour ambulatory monitors in 52 kids referred …

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study looks at whether detailed heart scans (echocardiograms and MRIs) can improve how doctors predict short-term risks in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension). Researchers will follow 50 adults for 6 months to see if addin…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This observational study will follow 5000 people with pulmonary hypertension to understand a severe complication called pulmonary hypertension crisis. Researchers will collect medical data and samples to build a risk prediction tool. The goal is to identify who is at risk and imp…

This study follows 50 adults who have had pulmonary endarterectomy surgery for chronic blood clots in the lungs. Researchers will measure walking ability, muscle strength, lung function, and frailty before and after surgery. The goal is to understand how recovery progresses and w…

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the back of the eye. Researchers will follow about 1,050 people with retinal diseases like diabetic retinopathy and healthy volunteers to see how these images can help detect early …

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This observational study is looking at whether people with primary aldosteronism (a cause of high blood pressure) have hormone levels that vary in cycles or differ between day and night. Researchers will collect urine samples over 24 hours from 100 participants to see if this met…

This study checks if a French version of the MEPS/MEPI elbow score works well for children aged 4 to 17. It includes kids with and without elbow injuries to see if the score accurately measures elbow pain and function. The goal is to make sure doctors can use this tool reliably i…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) for Black women and birthing persons. Researchers will work with community organizations and advisory boards to identify barriers and facilitators to implementation. The goal is to make the program …

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study uses special cameras to take detailed pictures of the eye's drainage system in people with glaucoma or high eye pressure. Half of the 50 participants will use Rhopressa eye drops daily for two weeks, while the other half will use artificial tears. The goal is to see if…

This study compares three new wearable blood pressure monitors (ABPMPro, Aktiia, and Spacelabs) to see how well they measure blood pressure and physical activity. One hundred adults with normal or high blood pressure will wear the devices for 48 hours. The goal is to find out if …

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study aims to better understand pre-eclampsia and intrauterine growth restriction (IUGR), serious pregnancy complications affecting about 9% of pregnancies. Researchers will collect placenta, blood, and urine samples from 500 pregnant women—both with and without these condit…

This study is a registry that will follow about 900 adults with both interstitial lung disease and pulmonary hypertension. Researchers will collect information on patients' medical history and track changes in their condition over time. The goal is to better understand these dise…

This study compares standard arm-cuff blood pressure checks to a new continuous monitor worn on the finger during outpatient surgery. Researchers want to see if the finger cuff catches low blood pressure episodes better than the usual method. About 188 adults having elective nonc…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This early-stage study looks at how the body's nervous system controls blood pressure when veins are stretched. Researchers will use a blood pressure cuff to temporarily block blood flow in the arm and measure nerve activity in the leg, along with vein size using an MRI. They wil…

This study looks at how binge drinking in mid-life (ages 50-64) affects blood pressure, small blood vessels, and nerve activity. It compares binge drinkers to non-drinkers and moderate drinkers. In a second phase, binge drinkers will try 8 weeks of aerobic exercise to see if it i…

This study is testing whether a mobile phone app can help pregnant women at high risk for preeclampsia in Karachi, Pakistan, monitor their blood pressure and symptoms at home. Fifty women will use the app to send daily readings to their healthcare team, who can then respond if ne…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study looks at whether women with high blood pressure who skip their medication have more sexual problems than those who take it regularly. Researchers will compare sexual function in 348 women using questionnaires and blood tests. The goal is to understand if not taking med…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study examines why fat accumulates in the right ventricle of people with pulmonary arterial hypertension (PAH) and how it affects heart function and exercise ability. Researchers will use MRI and blood tests in 75 adults with PAH to track changes over time. The goal is to be…

This study aims to find genes that cause high blood pressure starting in childhood. Researchers will follow 2,300 people aged 2 and older, including those with childhood-onset hypertension and their healthy relatives, for up to 10 years. Participants provide blood, urine, and che…

This study follows 27 pregnant women living at high altitude in Bolivia and compares them to women at sea level. Researchers will use heart ultrasounds and blood tests to see how the body adapts to low oxygen levels during pregnancy. The goal is to better understand why some wome…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This study follows 60 kidney transplant recipients in Denmark to find out how often blood vessel problems cause poor kidney function or hard-to-treat high blood pressure. Participants will get special imaging tests, and if a narrowed artery is found, they may receive balloon trea…

This study will analyze health records from 15,000 adults with high blood pressure in Brazil's public primary care system. Researchers want to see how often patients with uncontrolled blood pressure get their treatment adjusted. The goal is to understand patterns of care and iden…

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple heart monitoring method. Researchers will track 100 adults with high blood pressure who are at risk for OSA, using heart monitors and slee…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and often experience high blood pressure during physical activity. Researchers will test whether regular cycling exercise, a drug called Kuvan, or supplements like histidine and beta-alanine …

This study looks at whether giving older adults (65+) with diabetes or high blood pressure access to their visit notes and audio recordings of their appointments helps them feel better and manage their health. About 1,022 participants will be randomly assigned to receive either w…

This study looks at how taking 81mg of aspirin twice a day affects blood platelets in pregnant women who are at high risk for preeclampsia. Researchers will collect blood samples about 4 weeks after starting aspirin to measure platelet function. The goal is to understand the best…

This study uses a quick, painless eye scan (OCT) to see if blood vessels in the eye look different in people with high blood pressure or chronic kidney disease compared to healthy people. Researchers want to learn if these differences improve with treatment. About 150 adults aged…

This study is looking at 150 Division I athletes from historically Black colleges and universities (HBCUs) to see how not getting enough calories—called low energy availability—might harm their hearts. Researchers will measure things like artery stiffness, blood sugar, and choles…

This study aims to see if a short, interval fitness test (the IFT 30-15) can reliably measure heart and lung fitness in both healthy people and those with high blood pressure or obesity. Researchers will compare results from this test with a standard treadmill test and a six-minu…

This study looks at how changing the pressure on a ventilator affects the lungs and heart of very premature babies (born before 34 weeks). Researchers will try different pressure levels and use ultrasound and imaging to see which setting works best for breathing and blood flow. T…

This pilot study tests whether a drug called aprepitant (currently used for nausea) can lower a hormone called aldosterone in people with severe sleep apnea and high blood pressure. The study will enroll 24 adults and measure aldosterone levels before and after taking the drug or…

This study looks at why people with pulmonary arterial hypertension (PAH) lose muscle mass and how that affects their daily life and activity. Researchers will measure body composition, heart fat, diet, and physical function in 150 adults with PAH. No new treatment is being teste…

This study from Mayo Clinic is testing whether a 12-week progressive barbell strength training program can lower blood pressure and improve cholesterol in 200 sedentary adults. Participants will train three times a week with certified coaches. The goal is to see if this type of e…

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study looks at how bacteria in the mouth might help control blood pressure in children aged 10-18 with high blood pressure. Researchers will collect saliva and do simple mouth exams to compare these children with healthy peers. No drugs or treatments are given—the goal is to…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart strain to help develop better treatments in the future. About 60 adults aged 40 and older with COPD will…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers will use heart imaging and other tests to identify different patterns of heart dysfunction. The goal is to better understand these patterns so that future …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study examines how cells in the placenta manage waste and self-destruction in women with pregnancy complications like pre-eclampsia and intrauterine growth restriction. Researchers will take blood and urine samples from 50 pregnant women throughout their pregnancy and at del…

This study looks at whether a structured goal-setting program can help people with chronic conditions like high blood pressure, diabetes, or high cholesterol adopt healthier behaviors. Researchers will compare 600 participants who receive the program to those who get usual care. …

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study tests whether nicotinamide riboside, a form of vitamin B3, can improve how cells produce energy in people with combined pulmonary hypertension (CPH). CPH is a serious lung and heart condition with no approved treatments. Ten participants will receive both the supplemen…

This study looks at whether giving low-income adults aged 40 and older free meal kits and nutrition education can improve their food security, diet quality, mental health, and heart health. About 120 participants will be split into two groups: one gets meal kits plus nutrition cl…

This study is collecting blood samples from 100 pregnant women with and without preeclampsia to measure key proteins involved in the condition. The goal is to better understand the angiogenic imbalance that causes symptoms and to develop a device that filters out harmful proteins…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is tracking 70 adults on long-term dialysis to find out how often they develop high blood pressure in the lungs (pulmonary hypertension) and what causes it. Participants get heart ultrasounds and, if needed, more tests to confirm the condition. Researchers will follow …

This study is testing a new way to understand how nerves in the kidney affect blood pressure. About 19 adults with high blood pressure will receive mild electrical stimulation to kidney nerves before and after a procedure that quiets those nerves. The goal is to learn how the bod…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study aims to find genes that make some people with congenital heart defects develop a serious lung condition called pulmonary arterial hypertension (PAH). Researchers will analyze DNA from blood samples of 21 patients with heart defects who also have PAH. The goal is to ide…

This study from the University of Oxford looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel disease later in life. Researchers will follow 200 women who gave birth 10 to 25 years ago, using heart scans, exercise tests…

This study looks at whether adding a heart ultrasound (echocardiogram) to regular check-ups helps doctors better manage high blood pressure in young adults aged 18 to 40. Researchers will collect data from 750 participants during their routine clinic visits and follow them for up…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study is for 12 adults with severe brain injuries or tumors in the back part of the brain. Doctors will place two small pressure sensors to measure pressure in both the front and back of the brain. The goal is to learn what normal and dangerous pressure levels are in the bac…

This study tracks 25 adults with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes headaches and vision problems. Researchers will measure body mass index (BMI) every three months and see how it relates to the success of treatment…

This study looks at whether giving mothers in Brazil an extra $40 per month (compared to just $2) can protect their children's brain development and mental health. About 450 children aged 7-10 from low-income families will be followed for 2 years. Researchers will measure stress,…

This study looks at whether digital devices like smartwatches and blood pressure cuffs can help detect high blood pressure and related pregnancy problems in refugee women. About 75 pregnant refugee women will use these tools at home and complete surveys. The goal is to see if thi…

This study is testing a new device that measures pressure inside the skull without needing surgery. The device uses a small pin on the head to detect tiny skull movements with each heartbeat. Researchers want to see if this non-invasive method can give useful information similar …

This study wants to improve how we measure children's recovery and experience after surgery and anesthesia. Researchers will translate and test a recovery scale for Danish children aged 4-12, and also develop a new questionnaire that lets children describe their own hospital expe…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study looks at how a specific biological pathway (BMPR2-activin) affects pulmonary hypertension in people with left heart disease. Researchers will follow 150 heart failure patients for one year, using blood tests, imaging, and heart tissue analysis. The goal is to better un…

This study is testing a unified first trimester screening approach to predict serious pregnancy complications like preeclampsia, fetal growth restriction, and birth defects. Researchers will enroll 2,000 pregnant women in the Czech Republic to see if combining standard tests can …

This study looks at how different arm positions change blood pressure readings in pregnant women. About 300 pregnant women will have their blood pressure taken with their arm in three positions: supported at heart level, on the lap, and hanging at the side. The goal is to find ou…

This study aims to find early signs of heart failure in women who had preeclampsia, a pregnancy complication involving high blood pressure. Researchers will use exercise stress tests and heart imaging to compare 250 women with a history of preeclampsia to 250 women with normal pr…

This study tests whether a clinical decision framework helps hospital doctors feel more confident when prescribing medications for older adults (65+) with chronic conditions like diabetes and high blood pressure. About 150 doctors will attend an educational session and complete s…

This study aims to find early molecular signs of preeclampsia, a serious pregnancy condition, by examining tissue from the womb (maternal-fetal interface) collected between weeks 9 and 15 of pregnancy. Researchers will compare samples from women who later develop preeclampsia wit…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will measure stiffness caused by blood pressure itself and by changes in the artery wall, and explore genetic factors. The goal is to…

This study is testing a new device called HemoCept during a standard heart procedure called right heart catheterization. The goal is to see if the device can accurately measure pressure in the heart's blood vessels. About 50 adults with conditions like pulmonary hypertension or h…

This study looks at whether a special heart pressure wave test can better track recovery in adults with chronic blood clots in the lungs (CTEPH) who are getting a procedure to open blocked arteries (balloon pulmonary angioplasty). Researchers will measure walking distance, heart …

This study is creating a registry of over 10,000 people with high blood pressure. Researchers will collect data on their health, treatments, and outcomes to find patterns and improve care. The goal is to help doctors provide more personalized and effective treatment based on real…

This study follows 462 women pregnant after egg donation or standard IVF to learn why pre-eclampsia is more common in egg donation pregnancies. Participants give blood samples and have regular check-ups throughout pregnancy. The goal is to find early warning signs and improve car…

This study is following 250 pregnant women diagnosed with preeclampsia, a serious condition involving high blood pressure and organ problems. Researchers will collect health data and samples from mothers and babies during pregnancy, at birth, and a few months after. The goal is t…

This study observes 50 adults having surgery to understand why their blood pressure drops. Researchers will use machine learning to find patterns in how different patients respond to treatment. The goal is to create personalized recommendations for managing low blood pressure dur…

This study is testing different combinations of how often and for how long people should interrupt prolonged sitting to improve blood pressure and blood sugar. Over 300 adults will take part in a 9-hour lab visit where they sit and take short walking breaks at various frequencies…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This observational study will enroll 8,000 adults undergoing routine health checkups. Researchers will measure hormone levels and collect health data to understand how environment, genes, and proteins interact in conditions like high blood pressure and diabetes. The goal is to cr…

This study is an observational registry that will follow about 120 adults with pulmonary hypertension who are being treated with the drug sotatercept at the Mayo Clinic. Researchers will track changes in quality of life, exercise ability, heart function, and side effects like ble…

This study will screen blood pressure in over 22,000 children aged 5-18 across South Africa. The goal is to create the country's first reference charts for normal blood pressure, since current charts are based on US and European data. This will help doctors correctly diagnose and…

This study aims to map gene activity in the placenta at two key points in pregnancy: the first trimester and at childbirth. Researchers will analyze small tissue samples from 100 pregnant women to understand how placental cells change over time. The goal is to learn more about no…

This pilot study looks at whether placing stents in narrowed arteries in the lower belly or pelvis can help lower blood pressure. About 20 adults with chronic blockages in these arteries will have their blood pressure measured before and 12 months after the procedure. The goal is…

This study watches 220 adults aged 75 and older who have high blood pressure. Researchers want to see if brief drops in daytime blood pressure (below 90 mmHg) raise the risk of falls, hospital stays, heart problems, or death. Participants wear a 24-hour blood pressure monitor and…

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This study looks at whether stretching the veins in your legs causes a rise in blood pressure when you stand up, a condition called orthostatic hypertension. Researchers will use a tilt table and inflatable trousers to gently stretch leg veins in 30 healthy adults and people with…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is creating a large database of children with pulmonary hypertension (high blood pressure in the lungs) to better understand how the disease progresses and how treatments work in real life. Researchers will follow 450 children and adolescents over time, collecting info…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study looks at what happens to blood pressure when healthy adults sleep only 4 hours a night. Researchers will compare normal-weight and obese participants to see if lack of sleep affects their blood pressure differently. The goal is to better understand the link between sle…

This study is checking whether people newly diagnosed with high blood pressure who also have high homocysteine levels are more likely to have early signs of heart stiffness. Researchers will measure homocysteine in blood and use ultrasound to look at heart function in 500 adults.…

This study is building a large database of 1,200 people with malignant hypertension, a severe form of high blood pressure that can damage organs quickly. Researchers will track patients for five years to learn how the disease behaves today and how doctors treat it. The goal is to…

This study is building a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health. No treatments or …

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study looks at how the body controls blood pressure and heart rate in healthy young adults and older adults with high blood pressure. Participants will do tests like standing up and cycling while their heart and blood vessels are monitored. The goal is to better understand t…

This early-stage study tests a new tablet called F230 in 136 healthy adults to see if it is safe and how the body processes it. The drug is designed to treat pulmonary hypertension, a serious lung condition. Researchers will also check if food changes how the drug works. This stu…

This study looks at how often the diaphragm — the main muscle used for breathing — becomes weak after a C-section in women with severe preeclampsia. Researchers will use ultrasound to measure diaphragm movement before and 24 hours after surgery in 52 women. The goal is to find ou…

This study looks at how tiny particles released by the placenta, called extracellular vesicles, affect pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect samples from 360 pregnant and non-pregnant women to understand these particles bett…

This study is collecting blood, amniotic fluid, and placenta samples from 100 pregnant women, including those with pregnancy-induced hypertension and those who have had a miscarriage. Researchers will test these samples to look for differences in immune cells and other markers. T…

This study is looking at people with pulmonary arterial hypertension (PAH), those with a genetic risk but no disease, and healthy individuals. Researchers aim to find molecular and physical markers that explain why some people get PAH and others stay healthy. The goal is to impro…

This study is creating and testing a questionnaire called SAVOIR to measure how much people with pulmonary arterial hypertension (PAH) understand about their condition. Up to 215 patients and expert judges will help ensure the questions are clear, relevant, and reliable. The goal…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study looks at whether a slow-release injection (Durysta) can replace some daily eye drops for glaucoma, reducing eye surface inflammation. Researchers will measure a marker called caspase-1 in 20 adults with open-angle glaucoma. The goal is to see if fewer drops lead to a h…

This study compares noninvasive heart ultrasound (echocardiogram) with the standard invasive right heart catheterization in 3000 people referred for catheterization. The goal is to see if ultrasound can accurately measure heart function and blood flow during exercise. Participant…

This study is looking at whether the level of bicarbonate in the blood can help predict if a patient will die or need intensive care within 48 hours of arriving at the emergency department. Researchers will track 6,500 adults who have a blood test done as part of their regular ca…

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study looks at how blocking certain nerve signals for two weeks changes the way the body produces sugar in people who have both obesity and high blood pressure. Twelve participants will receive a placebo, a blood pressure drug, or a nerve-blocking drug in a random order. The…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study tests whether nurses using an AI tool can plan care as well as doctors for common problems like high blood pressure, diabetes, fever, and shortness of breath. About 672 adults in rural and semi-urban India will see both a nurse with AI and a doctor, and their visits wi…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …