New shot aims to keep blood pressure in check after hospital discharge

NCT ID NCT07511361

Recruiting now Disease control Sponsor: Kardigan, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study tests a drug called tonlamarsen in adults who were recently hospitalized for dangerously high blood pressure. Participants receive either the drug or a placebo as a shot under the skin every 4 weeks. The goal is to see if tonlamarsen can lower blood pressure and reduce a protein linked to hypertension, helping patients stay healthy after leaving the hospital.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tonlamarsen
What this could lead to: If it works, this could provide a new treatment option to help control blood pressure after a severe hypertensive episode, potentially reducing the risk of future hospitalizations.
What could go wrong: This is an early Phase 2b trial with only 100 participants, so results may not apply to everyone. The drug may not lower blood pressure significantly or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hypertensive Crisis hypertensive disorder hypertensive urgency malignant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE SEVERE HYPERTENSION HYPERTENSION HYPERTENSIVE EMERGENCY HYPERTENSIVE URGENCY

Contacts and locations

Locations

Baylor Scott and White Research Institute - Temple
RECRUITING

Temple, Texas, 76502, United States
Chattanooga Research & Medicine CHARM
RECRUITING

Chattanooga, Tennessee, 37404, United States
Homestead Associates in Research
RECRUITING

Homestead, Florida, 33033, United States
Laguna Clinical Research Associates
RECRUITING

Laredo, Texas, 78041, United States
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Research Innovations, LLC
RECRUITING

Beavercreek, Ohio, 05431, United States
Richmond University Medical Center (RUMC)
RECRUITING

Staten Island, New York, 10310, United States
Western Nephrology and Metabolic Bone Disease, PC - Arvada
RECRUITING

Arvada, Colorado, 80002, United States

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