Morning or evening? study tests best time for BP meds in obesity
NCT ID NCT04971720
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participants either sacubitril/valsartan or valsartan at different times of day for 28 days to see which timing better restores normal blood pressure patterns.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Sacubitril/Valsartan and Valsartan
- What this could lead to
- If successful, this could show that timing blood pressure medication to match the body's natural rhythms improves nighttime blood pressure control in obese individuals, potentially reducing their heart disease risk.
- What could go wrong
- This is a small, early-phase study with only 160 participants over 28 days. The results may not apply to all obese individuals, and the benefit of timing may be modest or not clinically significant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
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