Sound waves to zap hypertension? new trial tests ultrasound treatment

NCT ID NCT06559891

Recruiting now Disease control Sponsor: SoniVie Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 6 times

Summary

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. About 261 adults with hypertension will either get the real procedure or a sham (fake) one. The goal is to see if this approach safely lowers blood pressure, possibly reducing the need for daily medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ultrasound energy delivered via a catheter to nerves around the kidney arteries
What this could lead to: If it works, this could offer a new, drug-free option to help control high blood pressure without daily pills.
What could go wrong: This is an early-stage device trial with only 261 participants. The procedure involves risks like blood vessel damage, and it may not lower blood pressure enough to replace medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION

Contacts and locations

Locations

Arkansas Heart Hospital
RECRUITING

Little Rock, Arkansas, 72211, United States
Ascension Alexian Brothers
RECRUITING

Elk Grove Village, Illinois, 60007, United States
Ascension St. John Clinical Research Institute
RECRUITING

Bartlesville, Oklahoma, 74006, United States
Ascension- Sacred Heart
RECRUITING

Pensecola, Florida, 32504, United States
Athens Hippokration
RECRUITING

Athens, Greece
Cardiology, PC
RECRUITING

Birmingham, Alabama, 35211, United States
Cardiovascular Institute of the South
RECRUITING

Houma, Louisiana, 70360, United States
Cedar-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Chippenham Hospital
RECRUITING

Richmond, Virginia, 23225, United States
Clinica Montevergine
RECRUITING

Mercogliano, Italy
Connecticut Clinical Research, LLC (Bridgeport)
RECRUITING

Bridgeport, Connecticut, 06610, United States
Dresden TUD University of Technology
RECRUITING

Dresden, Germany
Frankfurt Sankt Katharinen Krankenhaus
RECRUITING

Frankfurt, Germany
Freiburg Herzzenrtum
RECRUITING

Freiburg im Breisgau, Germany
Gulfport Memorial Hospital
RECRUITING

Gulfport, Mississippi, 39501, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Henry Ford Providence Hospital
RECRUITING

Southfield, Michigan, 48075, United States
Herne Marien Hospital
RECRUITING

Herne, Germany
Herzzentrum Leipzig
RECRUITING

Leipzig, Germany
HonorHealth
RECRUITING

Scottsdale, Arizona, 85258, United States
Hopital Saint André
RECRUITING

Bordeaux, France
Houston Medical Center
RECRUITING

Houston, Texas, 77004, United States
Hôpital Européen Georges-Pompidou
RECRUITING

Paris, France
Jackson Heart Clinic
RECRUITING

Jackson, Mississippi, 39216, United States
Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
Lancaster General Health
RECRUITING

Lancaster, Pennsylvania, 17603, United States
MUSC
RECRUITING

Mt. Pleasant, South Carolina, 29464, United States
Marienkrankenhaus Hamburg
RECRUITING

Hamburg, Germany
Monza Policlinico
RECRUITING

Monza, Italy
NC Heart and Vascular
RECRUITING

Raleigh, North Carolina, 27607, United States
Nyph/Cumc
RECRUITING

New York, New York, 10032, United States
Ochsner Medical Center
RECRUITING

New Orleans, Louisiana, 70121, United States
Ospedale Sant'Andrea
RECRUITING

Roma, Italy
Penn Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Plaza Medical Center of Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Saarland University Hospital
RECRUITING

Homburg, Germany
Sana Kliniken Lubeck
RECRUITING

Lübeck, Germany
Southern Illinois University, School of Medicine
RECRUITING

Springfield, Illinois, 62794, United States
St Lukes Hospital
RECRUITING

Kansas City, Missouri, 64131, United States
St Marks Hospital
RECRUITING

Salt Lake City, Utah, 37027, United States
St. Bernard's Medical Center
RECRUITING

Jonesboro, Arkansas, 72401, United States
St. John's Prairie Heart
RECRUITING

Springfield, Illinois, 62710, United States
St. Joseph
RECRUITING

Liverpool, New York, 13088, United States
Stanford University
RECRUITING

Palo Alto, California, 94305, United States
Thessaloniki Hippokration General Hospital
RECRUITING

Thessaloniki, Greece
University of Crete
RECRUITING

Heraklion, Greece
University of South Florida
RECRUITING

Tampa, Florida, 33606, United States
Universitätsklinikum Erlangen
RECRUITING

Erlangen, Germany
Virtua Health
RECRUITING

Camden, New Jersey, 08103, United States

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