Resistant hypertension

This early study tests a new device called HyperQure that uses a keyhole surgery to disable certain nerves around the kidneys. The goal is to help people with resistant hypertension—high blood pressure that stays high despite taking three or more medications. The study will enrol…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study tests whether beetroot powder, which is rich in nitrates, can help lower blood pressure in people with resistant hypertension (high blood pressure that doesn't respond well to standard medications). Researchers will monitor blood pressure changes in 50 participants ove…

This early study tests a new medicine called SC101, given as a single injection around the kidneys, for people with resistant high blood pressure and moderate to severe chronic kidney disease. The main goal is to check safety, with only 3 participants. Researchers will also monit…

This study tests whether the antibiotic minocycline can lower blood pressure in people whose hypertension does not respond to standard treatments. Researchers will give 120 adults either minocycline or a placebo daily for three months to see if the drug works by changing gut bact…

This study is for people with resistant hypertension, meaning their blood pressure stays high even with three or more medications. Researchers want to see if a drug that blocks endothelin-1, a substance that tightens blood vessels, can improve blood vessel function and lower bloo…

This study tests whether combining transcutaneous electrical nerve stimulation (TENS) with isometric exercise can improve blood pressure in people with resistant hypertension. Resistant hypertension means blood pressure stays high despite taking three or more medications. The tri…

This study tests whether a single daily pill containing three blood pressure medications can better control resistant hypertension compared to taking multiple separate drugs. Researchers will enroll 142 adults with high blood pressure that is not well controlled despite using 3 t…

This study follows 500 people in China with resistant hypertension who have already received the Symplicity Spyral renal denervation system. The device uses radiofrequency energy to calm overactive kidney nerves that can raise blood pressure. Researchers will track blood pressure…

This study tests a daily injection called MANP for people whose high blood pressure remains high despite taking three or more different medications. About 120 adults aged 18 to 80 will receive either MANP or a placebo for 42 days. The main goal is to see if MANP safely lowers day…

This study tests a procedure called renal denervation, which uses ultrasound to calm overactive kidney nerves, in 12 dialysis patients with hard-to-treat high blood pressure. The goal is to see if it safely lowers blood pressure over 3 to 6 months. It is a small, early-stage tria…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…