Resistant hypertension

This study tests an experimental drug called HRS-1780 in people with uncontrolled or resistant hypertension—high blood pressure that stays high despite treatment. The trial compares three different doses of HRS-1780 against a placebo to see if it safely lowers blood pressure. Par…

This Phase 3 trial tests aprocitentan, a drug already approved in some countries, for people with resistant hypertension—high blood pressure that stays high despite taking three or more medications. About 382 adults will receive either the drug or a placebo for 8 weeks. The main …

This study tests a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in 1,000 people with both resistant hypertension and multivessel coronary artery disease. Participants will undergo the procedure during a planned heart stent op…

This study tests a procedure that uses radiofrequency energy to disable certain nerves near the kidneys and abdomen. The goal is to see if this can safely lower blood pressure and improve blood sugar control in 20 adults with resistant hypertension and type 2 diabetes who have no…

This pilot study tests whether a non-invasive brain stimulation technique called temporal interference can safely help regulate blood pressure. Researchers will enroll 25 adults with either mild untreated hypertension or hard-to-treat hypertension, as well as people with low bloo…

This study tests whether focused power ultrasound can safely lower blood pressure in people with resistant hypertension (high blood pressure that doesn't respond to three or more drugs). About 220 adults will receive either the ultrasound treatment or a sham procedure. The main g…

This observational study looks at whether heart rate variability — a measure of the nervous system's control over the heart — is linked to how well people with resistant hypertension take their medications. Researchers will use a blood test to objectively check drug levels and co…

This study will follow 100 adults whose high blood pressure remains high despite taking at least two medications. Over three months, researchers will track changes in blood pressure and other health markers to find patterns that could help identify which patients might respond be…

This pilot study will test whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with resistant hypertension, untre…

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…