Resistant hypertension
MONDO:0100078A severe medical condition which is estimated to appear in 9-18% of hypertensive patients, in which treatment with 3 or more antihypertensive drugs including diuretics are ineffective.
Also known as: drug resistant hypertension
182 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Could a pacemaker also treat high blood pressure? a new device aims to do both.
Disease control TerminatedThis trial tests a special pacemaker called the Moderato System in people who need a pacemaker and have high blood pressure that is hard to control with medication. The device is implanted like a regular pacemaker and may help lower blood pressure by adjusting the heart's pacing.…
Phase: NA • Sponsor: BackBeat Medical Inc • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Could a pacemaker tame stubborn high blood pressure?
Disease control TerminatedThis trial tests a special pacemaker-like device, the Moderato System, designed to lower blood pressure in people who have resistant hypertension and already need a dual-chamber pacemaker. Participants are randomly assigned to have the device's blood-pressure-lowering feature tur…
Phase: NA • Sponsor: BackBeat Medical Inc • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Heart drug tested to fight COVID-19 complications
Disease control TerminatedThis study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…
Phase: PHASE2, PHASE3 • Sponsor: Cardiol Therapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Kidney nerve procedure tested for stubborn high blood pressure
Disease control TerminatedThis study looked at the long-term safety and effects of a procedure called renal denervation in 9 patients with resistant hypertension (high blood pressure that doesn't respond to multiple medications). The procedure uses a device to disrupt certain nerves in the kidney arteries…
Sponsor: Imperial College Healthcare NHS Trust • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Painkiller showdown: which is safer for the heart?
Knowledge-focused TerminatedThis study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…
Phase: PHASE4 • Sponsor: Platelet and Thrombosis Research, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC