Resistant hypertension

This Phase 3 trial tested a once-daily pill called baxdrostat in 218 adults with resistant hypertension—high blood pressure that stays high despite taking three or more medications. Participants received either baxdrostat or a placebo for 12 weeks. The main goal was to see if bax…

This Phase 3 trial tested a daily pill called baxdrostat in about 800 adults whose blood pressure stays high even when taking two or more other medications. Participants received either 1 mg, 2 mg, or a placebo for 12 weeks. The main goal was to see if baxdrostat could safely low…

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This Phase 3 trial tested a new drug called lorundrostat in over 1,000 adults whose high blood pressure remained uncontrolled despite taking 2 to 5 other medications. Participants received either lorundrostat or a placebo daily for 12 weeks. The main goal was to see if the drug l…

This study tested a new drug called baxdrostat in 326 adults whose high blood pressure was not controlled even with two or more medications. Participants took either 1 mg, 2 mg of baxdrostat, or a placebo daily for 12 weeks. The main goal was to see if baxdrostat could lower syst…

This study tested a new drug called XXB750 in 189 people with resistant hypertension—high blood pressure that doesn't get better with standard treatments. Participants received either a placebo or one of several doses of XXB750 as a shot under the skin, on top of their usual medi…

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This completed study looked at 111 people to see if measuring blood flow in the skin can help assess cardiovascular risk in those with resistant hypertension (high blood pressure that doesn't respond to multiple drugs). Researchers used a laser device to check how well tiny blood…

This study looked at over 1,100 adults in the US whose high blood pressure stays high despite taking multiple medications. Researchers checked if these people also have a hormone condition called endogenous hypercortisolism, where the body makes too much cortisol. Participants ga…

This study looked at 142 people with hard-to-treat high blood pressure who had a procedure called renal denervation, which uses energy to calm overactive kidney nerves. Researchers compared two types of sedation—dexmedetomidine versus a fentanyl-propofol combination—to see which …