New shot could tame stubborn high blood pressure

NCT ID NCT05562934

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called XXB750 in 189 people with resistant hypertension—high blood pressure that doesn't get better with standard treatments. Participants received either a placebo or one of several doses of XXB750 as a shot under the skin, on top of their usual medications. The goal was to see if XXB750 could safely lower blood pressure over 20 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: XXB750 (a biologic drug given as a shot under the skin)
What this could lead to: If successful, XXB750 could offer a new treatment option for people with hard-to-control high blood pressure, potentially reducing their risk of heart attack and stroke.
What could go wrong: This is a mid-stage trial with only 189 participants, so results may not apply to everyone. The drug may not lower blood pressure enough or could have side effects. It is not a cure, and patients will still need other medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder resistant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESISTANT HYPERTENSION

Contacts and locations

Locations

Alliance for Multispecialty Resrch

Wichita, Kansas, 67207, United States
American Clinical Trials

Acworth, Georgia, 30101, United States
Anderson Medical Research

Ft. Washington, Maryland, 20744, United States
Canvas Clinical Research

Lake Worth, Florida, 33467, United States
Capitol Cardiology Associates

Lanham, Maryland, 20706, United States
Cardiology Partners Clinical Research Institute

Wellington, Florida, 33449, United States
Clinical Trials Research Sacramento

Sacramento, California, 95821-2134, United States
Dominion Medical Associates

Richmond, Virginia, 23219, United States
Inpatient Research Clinical LLC

Miami Lakes, Florida, 33014, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
MD Medical Research

Oxon Hill, Maryland, 20745, United States
Manassas Clinical Research Center

Manassas, Virginia, 20110, United States
NexGen Research

Lima, Ohio, 45801, United States
Novartis Investigative Site

Adelaide, South Australia, 5000, Australia
Novartis Investigative Site

Perth, Western Australia, 6000, Australia
Novartis Investigative Site

Graz, 8036, Austria
Novartis Investigative Site

Vienna, 1190, Austria
Novartis Investigative Site

Pleven, 5800, Bulgaria
Novartis Investigative Site

Sofia, 1202, Bulgaria
Novartis Investigative Site

Sofia, 1233, Bulgaria
Novartis Investigative Site

Sofia, 1709, Bulgaria
Novartis Investigative Site

Guangzhou, Guangdong, 510080, China
Novartis Investigative Site

Baotou, Inner Mongolia, 014010, China
Novartis Investigative Site

Beijing, 101200, China
Novartis Investigative Site

Qingdao, 266000, China
Novartis Investigative Site

Shanghai, 200025, China
Novartis Investigative Site

Brandýs nad Labem, Czech Republic, 250 01, Czechia
Novartis Investigative Site

Prague, 128 08, Czechia
Novartis Investigative Site

Bobigny, 93009, France
Novartis Investigative Site

Lille, 59000, France
Novartis Investigative Site

Paris, 75015, France
Novartis Investigative Site

Tours, 37044, France
Novartis Investigative Site

Elsterwerda, Brandenburg, 04910, Germany
Novartis Investigative Site

Frankfurt am Main, Hesse, 60594, Germany
Novartis Investigative Site

Berlin, 10787, Germany
Novartis Investigative Site

Erlangen, 91054, Germany
Novartis Investigative Site

Ulm, 89077, Germany
Novartis Investigative Site

Bologna, BO, 40138, Italy
Novartis Investigative Site

Brescia, BS, 25123, Italy
Novartis Investigative Site

Milan, MI, 20122, Italy
Novartis Investigative Site

Milan, MI, 20162, Italy
Novartis Investigative Site

Pisa, PI, 56124, Italy
Novartis Investigative Site

Chikushino-shi, Fukuka, 818-8516, Japan
Novartis Investigative Site

Kanazawa, Ishikawa-ken, 920 8650, Japan
Novartis Investigative Site

Yokohama, Kanagawa, 232 0024, Japan
Novartis Investigative Site

Yokosuka, Kanagawa, 239-8567, Japan
Novartis Investigative Site

Kishiwada, Osaka, 596-0042, Japan
Novartis Investigative Site

Chuo Ku, Tokyo, 103-0027, Japan
Novartis Investigative Site

Chuo Ku, Tokyo, 104-0031, Japan
Novartis Investigative Site

Chuo-ku, Tokyo, 103-0027, Japan
Novartis Investigative Site

Amsterdam, North Holland, 1105 AZ, Netherlands
Novartis Investigative Site

Gdynia, 81-157, Poland
Novartis Investigative Site

Katowice, 40-648, Poland
Novartis Investigative Site

Krakow, 30-002, Poland
Novartis Investigative Site

Wroclaw, 52-416, Poland
Novartis Investigative Site

Bardejov, 085 01, Slovakia
Novartis Investigative Site

Košice, 040 01, Slovakia
Novartis Investigative Site

Nitra, 949 11, Slovakia
Novartis Investigative Site

Svidník, 089 01, Slovakia
Novartis Investigative Site

Seville, Andalusia, 41014, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08035, Spain
Novartis Investigative Site

Terrassa, Catalonia, 08221, Spain
Novartis Investigative Site

Pamplona, Navarre, 31008, Spain
Novartis Investigative Site

Barcelona, 08025, Spain
Novartis Investigative Site

Madrid, 28041, Spain
Novartis Investigative Site

Valencia, 46010, Spain
Novartis Investigative Site

Taipei, 10002, Taiwan
Novartis Investigative Site

Taipei, 110, Taiwan
Novartis Investigative Site

Taipei, 11217, Taiwan
Novartis Investigative Site

Taoyuan, 33305, Taiwan
Novartis Investigative Site

London, GBR, EC1M 6BQ, United Kingdom
Novartis Investigative Site

London, W1T 7HA, United Kingdom
Novartis Investigative Site

Salford, M6 8HD, United Kingdom
Orange County Research Center

Tustin, California, 92780, United States
Parkway Medical Center

Birmingham, Alabama, 35206, United States
Pinnacle Research Group Llc

Anniston, Alabama, 36207, United States
Tennessee Center For Clinical Trials

Tullahoma, Tennessee, 37388, United States
The Research Center of the Upstate

Greenville, South Carolina, 29607, United States

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