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New shot could tame stubborn high blood pressure

NCT ID NCT05562934

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called XXB750 in 189 people with resistant hypertension—high blood pressure that doesn't get better with standard treatments. Participants received either a placebo or one of several doses of XXB750 as a shot under the skin, on top of their usual medications. The goal was to see if XXB750 could safely lower blood pressure over 20 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

XXB750 (a biologic drug given as a shot under the skin)

What this could lead to

If successful, XXB750 could offer a new treatment option for people with hard-to-control high blood pressure, potentially reducing their risk of heart attack and stroke.

What could go wrong

This is a mid-stage trial with only 189 participants, so results may not apply to everyone. The drug may not lower blood pressure enough or could have side effects. It is not a cure, and patients will still need other medications.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder resistant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESISTANT HYPERTENSION

Contacts and locations

Locations

  • Alliance for Multispecialty Resrch

    Wichita, Kansas, 67207, United States

  • American Clinical Trials

    Acworth, Georgia, 30101, United States

  • Anderson Medical Research

    Ft. Washington, Maryland, 20744, United States

  • Canvas Clinical Research

    Lake Worth, Florida, 33467, United States

  • Capitol Cardiology Associates

    Lanham, Maryland, 20706, United States

  • Cardiology Partners Clinical Research Institute

    Wellington, Florida, 33449, United States

  • Clinical Trials Research Sacramento

    Sacramento, California, 95821-2134, United States

  • Dominion Medical Associates

    Richmond, Virginia, 23219, United States

  • Inpatient Research Clinical LLC

    Miami Lakes, Florida, 33014, United States

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • MD Medical Research

    Oxon Hill, Maryland, 20745, United States

  • Manassas Clinical Research Center

    Manassas, Virginia, 20110, United States

  • NexGen Research

    Lima, Ohio, 45801, United States

  • Novartis Investigative Site

    Adelaide, South Australia, 5000, Australia

  • Novartis Investigative Site

    Perth, Western Australia, 6000, Australia

  • Novartis Investigative Site

    Graz, 8036, Austria

  • Novartis Investigative Site

    Vienna, 1190, Austria

  • Novartis Investigative Site

    Pleven, 5800, Bulgaria

  • Novartis Investigative Site

    Sofia, 1202, Bulgaria

  • Novartis Investigative Site

    Sofia, 1233, Bulgaria

  • Novartis Investigative Site

    Sofia, 1709, Bulgaria

  • Novartis Investigative Site

    Guangzhou, Guangdong, 510080, China

  • Novartis Investigative Site

    Baotou, Inner Mongolia, 014010, China

  • Novartis Investigative Site

    Beijing, 101200, China

  • Novartis Investigative Site

    Qingdao, 266000, China

  • Novartis Investigative Site

    Shanghai, 200025, China

  • Novartis Investigative Site

    Brandýs nad Labem, Czech Republic, 250 01, Czechia

  • Novartis Investigative Site

    Prague, 128 08, Czechia

  • Novartis Investigative Site

    Bobigny, 93009, France

  • Novartis Investigative Site

    Lille, 59000, France

  • Novartis Investigative Site

    Paris, 75015, France

  • Novartis Investigative Site

    Tours, 37044, France

  • Novartis Investigative Site

    Elsterwerda, Brandenburg, 04910, Germany

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60594, Germany

  • Novartis Investigative Site

    Berlin, 10787, Germany

  • Novartis Investigative Site

    Erlangen, 91054, Germany

  • Novartis Investigative Site

    Ulm, 89077, Germany

  • Novartis Investigative Site

    Bologna, BO, 40138, Italy

  • Novartis Investigative Site

    Brescia, BS, 25123, Italy

  • Novartis Investigative Site

    Milan, MI, 20122, Italy

  • Novartis Investigative Site

    Milan, MI, 20162, Italy

  • Novartis Investigative Site

    Pisa, PI, 56124, Italy

  • Novartis Investigative Site

    Chikushino-shi, Fukuka, 818-8516, Japan

  • Novartis Investigative Site

    Kanazawa, Ishikawa-ken, 920 8650, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 232 0024, Japan

  • Novartis Investigative Site

    Yokosuka, Kanagawa, 239-8567, Japan

  • Novartis Investigative Site

    Kishiwada, Osaka, 596-0042, Japan

  • Novartis Investigative Site

    Chuo Ku, Tokyo, 103-0027, Japan

  • Novartis Investigative Site

    Chuo Ku, Tokyo, 104-0031, Japan

  • Novartis Investigative Site

    Chuo-ku, Tokyo, 103-0027, Japan

  • Novartis Investigative Site

    Amsterdam, North Holland, 1105 AZ, Netherlands

  • Novartis Investigative Site

    Gdynia, 81-157, Poland

  • Novartis Investigative Site

    Katowice, 40-648, Poland

  • Novartis Investigative Site

    Krakow, 30-002, Poland

  • Novartis Investigative Site

    Wroclaw, 52-416, Poland

  • Novartis Investigative Site

    Bardejov, 085 01, Slovakia

  • Novartis Investigative Site

    Košice, 040 01, Slovakia

  • Novartis Investigative Site

    Nitra, 949 11, Slovakia

  • Novartis Investigative Site

    Svidník, 089 01, Slovakia

  • Novartis Investigative Site

    Seville, Andalusia, 41014, Spain

  • Novartis Investigative Site

    Barcelona, Catalonia, 08035, Spain

  • Novartis Investigative Site

    Terrassa, Catalonia, 08221, Spain

  • Novartis Investigative Site

    Pamplona, Navarre, 31008, Spain

  • Novartis Investigative Site

    Barcelona, 08025, Spain

  • Novartis Investigative Site

    Madrid, 28041, Spain

  • Novartis Investigative Site

    Valencia, 46010, Spain

  • Novartis Investigative Site

    Taipei, 10002, Taiwan

  • Novartis Investigative Site

    Taipei, 110, Taiwan

  • Novartis Investigative Site

    Taipei, 11217, Taiwan

  • Novartis Investigative Site

    Taoyuan, 33305, Taiwan

  • Novartis Investigative Site

    London, GBR, EC1M 6BQ, United Kingdom

  • Novartis Investigative Site

    London, W1T 7HA, United Kingdom

  • Novartis Investigative Site

    Salford, M6 8HD, United Kingdom

  • Orange County Research Center

    Tustin, California, 92780, United States

  • Parkway Medical Center

    Birmingham, Alabama, 35206, United States

  • Pinnacle Research Group Llc

    Anniston, Alabama, 36207, United States

  • Tennessee Center For Clinical Trials

    Tullahoma, Tennessee, 37388, United States

  • The Research Center of the Upstate

    Greenville, South Carolina, 29607, United States