One pill to rule them all? new combo tackles resistant hypertension

NCT ID NCT07259733

Recruiting now Disease control Sponsor: Instituto Dante Pazzanese de Cardiologia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single daily pill containing three blood pressure medications can better control resistant hypertension compared to taking multiple separate drugs. Researchers will enroll 142 adults with high blood pressure that is not well controlled despite using 3 to 5 different medications. Participants will either switch to the triple-combination pill or continue their usual care, and blood pressure will be measured over 24 hours after 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Triple fixed-dose combination of perindopril, indapamide, and amlodipine
What this could lead to: If successful, this could offer a simpler, more effective way to control resistant hypertension, potentially reducing heart attack and stroke risk.
What could go wrong: This is a small, early-stage trial (142 participants) at a single center, so results may not apply broadly. The open-label design could introduce bias, and the simplified regimen may not work for everyone.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder resistant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APPARENT RESISTANT HYPERTENSION HIGH BLOOD PRESSURE HYPERTENSION

Contacts and locations

Locations

Instituto Dante Pazzanese de Cardiologia
RECRUITING

São Paulo, São Paulo, 04012909, Brazil

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