New shot could tame stubborn high blood pressure

NCT ID NCT06343298

Recruiting now Disease control Sponsor: E-Star BioTech, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a daily injection called MANP for people whose high blood pressure remains high despite taking three or more different medications. About 120 adults aged 18 to 80 will receive either MANP or a placebo for 42 days. The main goal is to see if MANP safely lowers daytime blood pressure measured over 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MANP (modified atrial natriuretic peptide)
What this could lead to: If successful, this could offer a new daily injection option for people whose high blood pressure is not controlled by multiple oral medications.
What could go wrong: This is an early Phase 2 trial with only 120 participants, so results may not apply to everyone. The injection is daily for 42 days, and side effects or lack of effectiveness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

resistant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFICULT TO CONTROL HYPERTENSION

Contacts and locations

Locations

Aa Mrc Llc
RECRUITING

Flint, Michigan, 48504, United States
Aavon Clinical Trials
RECRUITING

Richmond, Texas, 77407, United States
Alta Pharmaceutical Research Center
RECRUITING

Peachtree Corners, Georgia, 30092, United States
Amicis Research Center - Beverly Hills
RECRUITING

Beverly Hills, California, 90211, United States
Amicis Research Center - Granada Hills
RECRUITING

Granada Hills, California, 91344, United States
Amicis Research Center - Palmdale
RECRUITING

Palmdale, California, 93551, United States
Amicis Research Site - Valencia
RECRUITING

Valencia, California, 91355, United States
Arrow Clinical Trials
RECRUITING

Daytona Beach, Florida, 32117, United States
Cedar Crosse Research Center
RECRUITING

Chicago, Illinois, 60607, United States
Clinical Investigations of Texas
RECRUITING

Plano, Texas, 75075, United States
Cowry Health
RECRUITING

Acworth, Georgia, 30101, United States
Dallas Renal Group
RECRUITING

Dallas, Texas, 75230, United States
East Texas Cardiology
RECRUITING

Houston, Texas, 77002, United States
Evolution Clinical Trials
RECRUITING

Miami, Florida, 33122, United States
Interventional Cardiology Medical Group
WITHDRAWN

West Hills, California, 91308, United States
K&R Research LLC
RECRUITING

Marion, Ohio, 43302, United States
Lynn Institute of the Ozarks
RECRUITING

Little Rock, Arkansas, 72204, United States
Monroe Biomedical Research
RECRUITING

Monroe, North Carolina, 28112, United States
Office of Dr. Edward Portnoy MD
RECRUITING

Westlake Village, California, 91361, United States
Orange County Research Center
RECRUITING

Lake Forest, California, 92630, United States
Pioneer Research Solutions
RECRUITING

Houston, Texas, 77099, United States
Prime Clinical Research
RECRUITING

Mansfield, Texas, 76063, United States
Prime Research
ACTIVE_NOT_RECRUITING

Coppell, Texas, 75019, United States
Revival Research
RECRUITING

Sherman, Texas, 75092, United States
Revival Research Institute, LLC
RECRUITING

Dearborn, Michigan, 48126, United States
Royal Research Corp
RECRUITING

Hollywood, Florida, 33021, United States
SM Research Center
RECRUITING

Biscayne Park, Florida, 33161, United States
Superior Clinical Research
RECRUITING

Smithfield, North Carolina, 27577, United States
Tristar Clinical Investigations, P.C.
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19114, United States