New device zaps kidney nerves to lower blood pressure in Real-World study
NCT ID NCT06297291
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is tracking 1,000 patients with high blood pressure who receive the Paradise Ultrasound Renal Denervation treatment. The procedure uses ultrasound energy to calm overactive nerves near the kidneys, which can help lower blood pressure. Researchers are monitoring blood pressure changes and medication use over time to see how well the device works in everyday medical practice.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Paradise Ultrasound Renal Denervation System (a catheter-based device that uses ultrasound energy to calm nerves near the kidneys)
What this could lead to
If successful, this study could confirm that the Paradise system is a safe and effective long-term option for lowering blood pressure in patients who cannot control it with lifestyle changes or medication.
What could go wrong
This is a post-approval observational study, not a randomized controlled trial, so results may be less definitive. The procedure carries risks such as injury to blood vessels or kidneys, and some patients may not experience significant blood pressure reduction.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Albany Medical Center
RECRUITINGAlbany, New York, 12208, United States
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Ascension Sacred Heart
RECRUITINGPensacola, Florida, 32504, United States
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Ascension Saint Thomas
RECRUITINGNashville, Tennessee, 37205, United States
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Ascension Seton
RECRUITINGAustin, Texas, 78705, United States
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Ascension via Christi St. Francis
RECRUITINGWichita, Kansas, 67214, United States
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Bridgeport Hosptial
RECRUITINGBridgeport, Connecticut, 06610, United States
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Columbia University Medical Center/New York Presbyterian Hospital
RECRUITINGNew York, New York, 10032, United States
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Dallas VAMC
RECRUITINGDallas, Texas, 75216, United States
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Durham VA Health System
RECRUITINGDurham, North Carolina, 27705, United States
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Henry Ford Health
RECRUITINGDetroit, Michigan, 48202, United States
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Inova Fairfax Hospital
RECRUITINGFairfax, Virginia, 22042, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Metropolitan Heart & Vascular Institute
RECRUITINGCoon Rapids, Minnesota, 55433, United States
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NYU Langone Health - Bellevue Hosptial
RECRUITINGNew York, New York, 10016, United States
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NewYork-Presbyterian Brooklyn Methodist Hospital
RECRUITINGBrooklyn, New York, 11215, United States
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Pacific Heart Institute
RECRUITINGSanta Monica, California, 90404, United States
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Penn Medicine
RECRUITINGPhildelphia, Pennsylvania, 19104, United States
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Prisma Health Richland Hospital
RECRUITINGColumbia, South Carolina, 29203, United States
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Rocky Mountain Regional VAMC
RECRUITINGAurora, Colorado, 80045, United States
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Saint Luke's Mid America Heart Institute
RECRUITINGKansas City, Missouri, 64111, United States
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Southern Illinois University, Memorial Medical Center
RECRUITINGSpringfield, Illinois, 62702, United States
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Spartanburg Regional Medical Center
RECRUITINGSpartanburg, South Carolina, 29303, United States
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St. Mark's Hospital
RECRUITINGSalt Lake City, Utah, 84124, United States
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Stony Brook Medicine
RECRUITINGStony Brook, New York, 11794, United States
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Sutter Institute for Medical Research
RECRUITINGSacramento, California, 95816, United States
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Swedish Medical Center
RECRUITINGSeattle, Washington, 98122, United States
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TCR Institute
RECRUITINGKingwood, Texas, 77339, United States
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Tampa Cardiovascular Interventions and Research
RECRUITINGTampa, Florida, 33614, United States
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The Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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The Cardiac & Vascular Institute
RECRUITINGGainesville, Florida, 32605, United States
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Touro Infirmary
RECRUITINGNew Orleans, Louisiana, 70112, United States
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UC Davis Medical Center
RECRUITINGSacramento, California, 95817, United States
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UPMC Harrisburg
RECRUITINGHarrisburg, Pennsylvania, 17110, United States
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University at Buffalo
RECRUITINGBuffalo, New York, 14203, United States
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University of Miami Health System
RECRUITINGMiami, Florida, 33136, United States
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University of North Carolina at Chapel Hill School of Medicine
RECRUITINGChapel Hill, North Carolina, 27599, United States
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Virtua Health
RECRUITINGMarlton, New Jersey, 08053, United States
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Wellstar Kennestone Hospital
RECRUITINGMarietta, Georgia, 30060, United States
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