Could zapping kidney nerves tame tough blood pressure in polycystic kidney disease?
NCT ID NCT05460169
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a device that uses ultrasound to burn nerves around the kidney arteries, aiming to lower blood pressure in people with autosomal dominant polycystic kidney disease (ADPKD) whose blood pressure remains high despite medication. 44 participants will be randomly assigned to get the procedure right away or after a delay. The main goal is to see if the treatment safely reduces 24-hour blood pressure at 3 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Paradise® Renal Denervation System (ultrasound catheter to ablate kidney nerves)
- What this could lead to
- If it works, this could offer a new way to control blood pressure in people with polycystic kidney disease, potentially slowing kidney damage.
- What could go wrong
- This is a small, early feasibility study with only 44 participants. The blood pressure drop may be modest, and long-term safety or effectiveness is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University Hospital FAU Erlangen-Nürnberg
Erlangen, 91054, Germany
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