Can brain training lift the weight of depression in kidney disease?

NCT ID NCT07745920

Recruiting now Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This pilot study explores whether digital neurotherapy or coaching with a wellness coach can help manage depressive symptoms and pain in people with autosomal dominant polycystic kidney disease (ADPKD). Participants will be assigned to one of these approaches or to an education-only group. The goal is to see if these interventions are practical and effective in improving mood and reducing discomfort.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Digital Neurotherapy (REJUVENATE) and Capacity Coaching
What this could lead to: If effective, these digital tools could offer new, accessible ways to manage depression and pain in people with ADPKD, improving quality of life without medication.
What could go wrong: This is a small pilot study, so results may not be definitive. The interventions are behavioral, and their success depends on user engagement and adherence.

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Conditions

The condition(s) this trial relates to.

autosomal dominant polycystic kidney disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

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