Could a gene test pick the right blood pressure pill for black patients?
NCT ID NCT04840342
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether the drug eplerenone works better than amlodipine for controlling high blood pressure in Black adults who carry a specific gene variant (LSD1 risk allele). About 300 participants will follow a controlled diet and take escalating doses of one of the two drugs for four weeks. The goal is to see if a gene-guided approach can improve blood pressure control and reduce kidney damage in this group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Eplerenone and amlodipine
What this could lead to
If successful, this could point toward a more effective, gene-targeted treatment for high blood pressure in Black patients with a specific genetic variant.
What could go wrong
This is a phase 4 trial with a moderate sample size, but it only includes Black adults with a specific gene variant, so results may not apply to everyone. The study is also not yet recruiting, and outcomes may not lead to a new standard of care.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's
Boston, Massachusetts, 02115, United States