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Real-world safety check for entresto in japanese hypertension patients

NCT ID NCT05976230

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows about 1,100 Japanese adults with high blood pressure who are prescribed Entresto tablets. Researchers track side effects like low blood pressure, high potassium, and kidney issues over 52 weeks. The goal is to see how safe and effective Entresto is in everyday medical practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Entresto (sacubitril/valsartan)

What this could lead to

If successful, this study could confirm that Entresto is a safe and effective long-term option for managing high blood pressure in Japanese patients.

What could go wrong

This is an observational study, not a controlled trial, so results may be influenced by other factors. Risks include low blood pressure, high potassium, and kidney problems.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION

Contacts and locations

Locations

  • Novartis Investigative Site

    Anjo, Aichi-ken, 444-1154, Japan

  • Novartis Investigative Site

    Ichinomiya, Aichi-ken, 494-0001, Japan

  • Novartis Investigative Site

    Kasugai, Aichi-ken, 487-0024, Japan

  • Novartis Investigative Site

    Nagoya, Aichi-ken, 460-0004, Japan

  • Novartis Investigative Site

    Okazaki, Aichi-ken, 444-0856, Japan

  • Novartis Investigative Site

    Ōbu, Aichi-ken, 474-0044, Japan

  • Novartis Investigative Site

    Toyohashi, Aichi-ken, 440-0836, Japan

  • Novartis Investigative Site

    Yatomi, Aichi-ken, 498-0048, Japan

  • Novartis Investigative Site

    Inzai, Chiba, 270-1334, Japan

  • Novartis Investigative Site

    Matsudo, Chiba, 270-0034, Japan

  • Novartis Investigative Site

    Sakura, Chiba, 285-8765, Japan

  • Novartis Investigative Site

    Yotsukaidō, Chiba, 284-0027, Japan

  • Novartis Investigative Site

    Matsuyama, Ehime, 790-0051, Japan

  • Novartis Investigative Site

    Matsuyama, Ehime, 790-0932, Japan

  • Novartis Investigative Site

    Saijō, Ehime, 799-1371, Japan

  • Novartis Investigative Site

    Fukuoka, Fukuoka, 815-0033, Japan

  • Novartis Investigative Site

    Fukuoka, Fukuoka, 815-0041, Japan

  • Novartis Investigative Site

    Kasuga, Fukuoka, 816-0807, Japan

  • Novartis Investigative Site

    Kasuga, Fukuoka, 816-0833, Japan

  • Novartis Investigative Site

    Kasuya Gun, Fukuoka, 811-2202, Japan

  • Novartis Investigative Site

    Kitakyushu, Fukuoka, 804-0081, Japan

  • Novartis Investigative Site

    Kitakyushu, Fukuoka, 805-0019, Japan

  • Novartis Investigative Site

    Kurume, Fukuoka, 830-0011, Japan

  • Novartis Investigative Site

    Nakagawa, Fukuoka, 811-1244, Japan

  • Novartis Investigative Site

    Omuta, Fukuoka, 837-0916, Japan

  • Novartis Investigative Site

    Yame, Fukuoka, 834-0004, Japan

  • Novartis Investigative Site

    Hiroshima, Hiroshima, 731-0102, Japan

  • Novartis Investigative Site

    Hiroshima, Hiroshima, 731-0154, Japan

  • Novartis Investigative Site

    Hiroshima, Hiroshima, 731-0221, Japan

  • Novartis Investigative Site

    Takehara, Hiroshima, 725-0026, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 001-0017, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 060-0031, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 064-0802, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 064-0809, Japan

  • Novartis Investigative Site

    Akashi, Hyōgo, 673-0023, Japan

  • Novartis Investigative Site

    Amagasaki, Hyōgo, 660-0861, Japan

  • Novartis Investigative Site

    Kasai, Hyōgo, 679-0103, Japan

  • Novartis Investigative Site

    Kobe, Hyōgo, 650-0047, Japan

  • Novartis Investigative Site

    Kobe, Hyōgo, 651-1302, Japan

  • Novartis Investigative Site

    Kobe, Hyōgo, 651-1505, Japan

  • Novartis Investigative Site

    Kobe, Hyōgo, 651-2135, Japan

  • Novartis Investigative Site

    Kobe, Hyōgo, 654-0121, Japan

  • Novartis Investigative Site

    Nishinomiya, Hyōgo, 663-8107, Japan

  • Novartis Investigative Site

    Bandō, Ibaraki, 306-0631, Japan

  • Novartis Investigative Site

    Chikusei, Ibaraki, 309-1195, Japan

  • Novartis Investigative Site

    Koga, Ibaraki, 306-0232, Japan

  • Novartis Investigative Site

    Moriya, Ibaraki, 302-0118, Japan

  • Novartis Investigative Site

    Ryūgasaki, Ibaraki, 301-0005, Japan

  • Novartis Investigative Site

    Kanazawa, Ishikawa-ken, 920-0007, Japan

  • Novartis Investigative Site

    Kagoshima, Kagoshima-ken, 892-0862, Japan

  • Novartis Investigative Site

    Aiko-gun, Kanagawa, 243-0301, Japan

  • Novartis Investigative Site

    Fujisawa, Kanagawa, 252-0804, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 225-0013, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 2260025, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 2270046, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 232-0052, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 235-0045, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 241-0821, Japan

  • Novartis Investigative Site

    Yokosuka, Kanagawa, 238-0007, Japan

  • Novartis Investigative Site

    Kumamoto, Kumamoto, 862-0924, Japan

  • Novartis Investigative Site

    Yamaga, Kumamoto, 861-0382, Japan

  • Novartis Investigative Site

    Iki, Nagasaki, 811-5135, Japan

  • Novartis Investigative Site

    Nagasaki, Nagasaki, 852-8055, Japan

  • Novartis Investigative Site

    Nagasaki, Nagasaki, 852-8511, Japan

  • Novartis Investigative Site

    Nakatsu, Oita Prefecture, 871-0152, Japan

  • Novartis Investigative Site

    Ōita, Oita Prefecture, 870-0837, Japan

  • Novartis Investigative Site

    Kurashiki, Okayama-ken, 710-1101, Japan

  • Novartis Investigative Site

    Kurashiki, Okayama-ken, 713-8121, Japan

  • Novartis Investigative Site

    Hirakata, Osaka, 573-0058, Japan

  • Novartis Investigative Site

    Ikeda, Osaka, 563-0047, Japan

  • Novartis Investigative Site

    Minoo, Osaka, 562-0046, Japan

  • Novartis Investigative Site

    Moriguchi, Osaka, 570-0012, Japan

  • Novartis Investigative Site

    Moriguchi, Osaka, 570-8507, Japan

  • Novartis Investigative Site

    Osaka, Osaka, 533-0013, Japan

  • Novartis Investigative Site

    Osaka, Osaka, 534-0024, Japan

  • Novartis Investigative Site

    Suita, Osaka, 565-0862, Japan

  • Novartis Investigative Site

    Suita, Osaka, 565-0874, Japan

  • Novartis Investigative Site

    Takatsuki, Osaka, 569-1121, Japan

  • Novartis Investigative Site

    Toyonaka, Osaka, 561-0881, Japan

  • Novartis Investigative Site

    Kashima, Saga-ken, 849-1311, Japan

  • Novartis Investigative Site

    Kishima-gun, Saga-ken, 849-1203, Japan

  • Novartis Investigative Site

    Tosu, Saga-ken, 841-0061, Japan

  • Novartis Investigative Site

    Ureshino, Saga-ken, 843-0302, Japan

  • Novartis Investigative Site

    Asaka, Saitama, 3510021, Japan

  • Novartis Investigative Site

    Fujimino, Saitama, 356-0011, Japan

  • Novartis Investigative Site

    Gyōda, Saitama, 361-0056, Japan

  • Novartis Investigative Site

    Kawaguchi, Saitama, 333-0847, Japan

  • Novartis Investigative Site

    Niiza, Saitama, 352-0023, Japan

  • Novartis Investigative Site

    Saitama, Saitama, 339-0033, Japan

  • Novartis Investigative Site

    Satte, Saitama, 340-0115, Japan

  • Novartis Investigative Site

    Sayama, Saitama, 350-1305, Japan

  • Novartis Investigative Site

    Tokorozawa, Saitama, 359-1106, Japan

  • Novartis Investigative Site

    Tokorozawa, Saitama, 359-1141, Japan

  • Novartis Investigative Site

    Akishima, Tokyo, 196-0015, Japan

  • Novartis Investigative Site

    Edogawa-ku, Tokyo, 134-0081, Japan

  • Novartis Investigative Site

    Hachiōji, Tokyo, 192-0918, Japan

  • Novartis Investigative Site

    Katsushika-ku, Tokyo, 125-0042, Japan

  • Novartis Investigative Site

    Kokubunji, Tokyo, 185-0011, Japan

  • Novartis Investigative Site

    Koto-ku, Tokyo, 135-0003, Japan

  • Novartis Investigative Site

    Machida, Tokyo, 194-0021, Japan

  • Novartis Investigative Site

    Machida, Tokyo, 1940013, Japan

  • Novartis Investigative Site

    Machida, Tokyo, 195-0074, Japan

  • Novartis Investigative Site

    Mitaka, Tokyo, 181-0013, Japan

  • Novartis Investigative Site

    Ōta-ku, Tokyo, 146-8531, Japan

  • Novartis Investigative Site

    Setagaya-ku, Tokyo, 157-0066, Japan

  • Novartis Investigative Site

    Shibuya City, Tokyo, 151-0053, Japan

  • Novartis Investigative Site

    Toshima-ku, Tokyo, 171-0014, Japan

  • Novartis Investigative Site

    Takaoka, Toyama, 939-1104, Japan

  • Novartis Investigative Site

    Shimonoseki, Yamaguchi, 759-6301, Japan

  • Novartis Investigative Site

    Yamaguchi, Yamaguchi, 754-0002, Japan

  • Novartis Investigative Site

    Fukuoka, 810-0044, Japan

  • Novartis Investigative Site

    Fukuoka, 810-0801, Japan

  • Novartis Investigative Site

    Fukuoka, 812-0025, Japan

  • Novartis Investigative Site

    Fukuoka, 812-0039, Japan

  • Novartis Investigative Site

    Fukuoka, 814-0163, Japan

  • Novartis Investigative Site

    Saitama, 3300074, Japan

  • Novartis Investigative Site

    Saitama, 338-0837, Japan