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Can pushing blood pressure lower save stroke Survivors' hearts?

NCT ID NCT04036409

Ongoing Disease control Sponsor: Hospital Israelita Albert Einstein Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about 3.5 years. The goal is to see if the lower target reduces the risk of heart attack, stroke, or death from heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
intensive blood pressure control (targeting systolic BP <120 mmHg using standard antihypertensive drugs)
What this could lead to
If successful, this could show that a lower blood pressure target after a stroke significantly reduces the risk of heart attacks, further strokes, and other major cardiovascular events.
What could go wrong
This is a large trial, but it is still testing a target, not a new drug. The intensive target may not be safe or tolerable for all patients, and results may not apply to everyone with a stroke.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction hypertensive disorder ischemic stroke transient ischemic attack vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD PRESSURE COGNITIVE IMPAIRMENT ISCHEMIC STROKE VASCULAR DISEASES

Contacts and locations

Locations

  • CMEP Centro Multidisciplinar de Ensino Especializado e Pesquisa Ltda

    Joinville, Santa Catarina, Brazil

  • Centro de Pesquisas Clinicas (Centro Universitário Cesmac / Hospital do Coração de Alagoas)

    Maceió, Alagoas, Brazil

  • Clínica Neurológica e Neurocirurgica de Joinville LTDA

    Joinville, Santa Catarina, 89202-165, Brazil

  • Clínica Silvestre Santé

    Rio Branco, Acre, Brazil

  • Clínica Vilela e Martin

    São José do Rio Preto, São Paulo, 15090-365, Brazil

  • Flumignano Instituto de Medicina

    Curitiba, Paraná, 82590-300, Brazil

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto

    São José do Rio Preto, São Paulo, 150900000, Brazil

  • Hospital Ana Nery

    Salvador, Estado de Bahia, 40323-010, Brazil

  • Hospital Carlos Fernando Malzoni

    Matão, São Paulo, 15990-060, Brazil

  • Hospital Geral de Fortaleza

    Fortaleza, Ceará, 60175-295, Brazil

  • Hospital Governador Celso Ramos

    Florianópolis, Santa Catarina, 88015-270, Brazil

  • Hospital Moinho de Ventos

    Porto Alegre, Rio Grande do Sul, 90035-000, Brazil

  • Hospital São Paulo

    São Paulo, São Paulo, 04037-002, Brazil

  • Hospital Univ. São Francisco de Assis na Providencia de Deus

    Bragança Paulista, São Paulo, 12916-542, Brazil

  • Hospital Universitário Maria Aparecida Pedrossian - UFMS

    Campo Grande, Mato Grosso do Sul, 79080-190, Brazil

  • Hospital Universitário Pedro Ernesto - UERJ

    Rio de Janeiro, Rio de Janeiro, 20551-030, Brazil

  • Hospital Universitário Professor Edgard Santos

    Salvador, Estado de Bahia, 40110-060, Brazil

  • Hospital das Clínicas da FMUSP

    São Paulo, São Paulo, (11) 2661-0000, Brazil

  • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo

    Ribeirão Preto, São Paulo, 14015-010, Brazil

  • Hospital de Clínicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-007, Brazil

  • Hospital de Clínicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • InCor - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP

    São Paulo, São Paulo, 05403-900, Brazil

  • Instituto Dante Pazzanese de Cardiologia

    São Paulo, São Paulo, 04012-909, Brazil

  • Instituto Hospitalar de Base Do Distrito Federal

    Brasília, Federal District, 70335900, Brazil

  • Irmandade da Santa Casa de Misericórdia de São Paulo

    São Paulo, São Paulo, 01221-020, Brazil

  • PROCAPE-Pronto Socorro Cardiológico de PE Prof. Luiz Tavares

    Recife, Pernambuco, 74970-240, Brazil

  • UPECLIN - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - FMB/UNESP

    Botucatu, Botucatu, 18618-686, Brazil

  • Universidade Estadual de Campinas - Hospital de Clínicas

    Campinas, São Paulo, 13083-888, Brazil

  • Universidade Federal de Goias

    Goiânia, Goiás, 74690-900, Brazil

  • Universidade Federal do Ceará / Hospital Universitário Walter Cantídio

    Fortaleza, Ceará, 60430-372, Brazil

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