Blood pressure drugs may slow brain damage in seniors

NCT ID NCT02472028

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether lowering blood pressure can slow the growth of white matter lesions in the brains of older adults (60-88) with high blood pressure and memory complaints. About 820 participants will receive either standard care or an enhanced blood pressure lowering strategy using common medications. The goal is to see if better blood pressure control can preserve brain health over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: blood pressure lowering drugs (diuretics, beta-blockers, ACE inhibitors, ARBs, calcium channel blockers)
What this could lead to: If successful, this could show that controlling blood pressure helps preserve brain health and slow cognitive decline in older adults.
What could go wrong: This is a Phase 4 study, but results may not apply to all older adults. Blood pressure medications can cause side effects like dizziness or falls.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebrovascular disorder Memory Disorders stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CEREBROVASCULAR DISORDERS

Contacts and locations

Locations

Memory Resources Centre and South of Ile de France Search - Broca Hospital
RECRUITING

Paris, 75013, France
Memory for Research and Resources Center / Neuroscience pole
NOT_YET_RECRUITING

Bordeaux, Pellegrin Hospital Group, 33076, France

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