Sound waves could make brain tumor diagnosis safer and smarter

This trial explores whether focused ultrasound can enhance the release of tumor DNA into the blood and spinal fluid, potentially making liquid biopsies a more reliable way to diagnose brain tumors. Researchers will use MRI-guided focused ultrasound to partially ablate the tumor in about 50 adults with new brain lesions, then collect blood and cerebrospinal fluid samples before and after the procedure. The goal is to see if this approach increases the amount of tumor DNA in circulation and improves the accuracy of molecular subtyping, which could reduce the need for invasive surgical biopsies.