New drug targets Hard-to-Treat cancers with RAS mutations

NCT ID NCT06884618

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests a new drug called RO7673396, alone or with other cancer treatments, in people with advanced solid tumors that have RAS mutations. The study has two parts: first to find a safe dose, then to see if it shrinks tumors. About 405 participants will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RO7673396
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have RAS mutations.
What could go wrong: This is a very early Phase 1 trial, so the drug may not be effective or safe. It is small and focused on finding the right dose, not on proving it works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASMS

Contacts and locations

Locations

City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States
Clinica Universidad de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Florida Cancer Specialists - Sarasota (North Catttlemen Rd)
RECRUITING

Sarasota, Florida, 34232, United States
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, 201315, China
Hubei Cancer Hospital
RECRUITING

Wuhan, 430079, China
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-3721, United States
National Cancer Centre - 30 Hospital Blvd
RECRUITING

Singapore, 168583, Singapore
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
New Zealand Clinical Research - Auckland
RECRUITING

Auckland, 1010, New Zealand
New Zealand Clinical Research - Christchurch
RECRUITING

Christchurch, 8011, New Zealand
Peter MacCallum Cancer Center
RECRUITING

Parkville, Victoria, 3052, Australia
Prince of Wales Hospital
RECRUITING

Hong Kong, Hong Kong
Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Rigshospitalet
RECRUITING

København Ø, 2100, Denmark
Smilow Cancer Hospital at Yale New Haven
RECRUITING

New Haven, Connecticut, 06519-1110, United States
South Texas Accelerated Research Therapeutics (START)
RECRUITING

San Antonio, Texas, 78229-4427, United States
St Vincent's Hospital Sydney
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Sun Yat-Sen University Cancer Center - Huangpu Campus
RECRUITING

Guangzhou, Guangdong, 510555, China
Sun Yat-Sen University Cancer Center;Department of Thoracic Surgery
RECRUITING

Guangzhou, 510050, China
University of Colorado - Anschutz Medical Campus - PPDS
RECRUITING

Aurora, Colorado, 80045, United States

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