NEOPLASMS

This study tested a new targeted pill, pralsetinib, against standard chemotherapy for people with a specific type of advanced lung cancer (RET fusion-positive) who had not yet received treatment. The goal was to see if the targeted drug could delay cancer growth better than chemo…

This study tested a new drug called OC-001, given alone or with an immunotherapy drug (Avelumab), in people with advanced cancers that had spread. The goal was to check safety and how the drug moves through the body. The study was stopped early and involved 73 participants with v…

This study tested a new drug called modakafusp alfa, given alone or with another drug (pembrolizumab), in adults with advanced solid tumors or melanoma that had spread. The goal was to find safe doses and check for side effects. The trial was stopped early, but it aimed to see if…

This early-phase study tested a combination of two drugs (niraparib and dostarlimab) in 47 children and teens with solid tumors that had come back or not responded to treatment. The goal was to find the safest dose and see if the drugs could shrink tumors. The study was terminate…

This study tested two new drug combinations for people with advanced clear cell kidney cancer that had already been treated. The goal was to see if adding the experimental drug NKT2152 to standard therapies could shrink tumors or slow the disease. The trial was stopped early, so …

This early-stage study tested a new drug called PF-07826390, given alone or with another drug (sasanlimab), in people with advanced solid tumors like lung, colon, kidney, and ovarian cancers. The goal was to check safety, find the right dose, and see if the drug shrinks tumors. O…

This early-stage trial tested a new drug called EO-3021 in adults with advanced solid tumors, especially stomach cancer, that have a specific marker (CLDN18.2). The study aimed to find safe doses and check for side effects, but it was terminated early. About 88 people were expect…

This early-stage study tested a new experimental drug (PF-07820435) alone or with another drug (sasanlimab) in people with advanced solid tumors like lung, skin, and kidney cancers. The goal was to check safety and find the right dose. Only 9 people took part before the study was…

This study compared two ways of giving palliative radiotherapy to people with cancer that has spread to the bones. The goal was to see which method better prevents nausea and vomiting caused by radiation, while still controlling pain. About 160 adults with bone metastases took pa…

This study aimed to understand how moderate or severe liver impairment changes the way the body handles the drug Onureg (oral azacitidine) in adults with certain blood cancers. Researchers planned to compare drug levels and safety in people with and without liver problems. Howeve…