Pfizer's new cancer combo shows early promise but trial halted
NCT ID NCT06285097
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-stage trial tested a new drug, PF-07820435, alone or with another immunotherapy (sasanlimab) in 9 people with advanced solid tumors like lung, skin, or kidney cancer. The main goals were to check safety and find the right dose. The study was terminated early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PF-07820435 (immune agonist) and sasanlimab (PD-1 blocker)
- What this could lead to
- If it works, this could point toward a new treatment option for advanced solid tumors like lung or skin cancer.
- What could go wrong
- This is a very early Phase 1 trial with only 9 participants, now terminated. It was designed to find safe doses, not to prove effectiveness. Many early cancer drugs fail to show benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Corewell Health (reference non-engagement letter)
Grand Rapids, Michigan, 49503, United States
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Florida Cancer Specialists Sarasota Drug Development Unit
Sarasota, Florida, 34232, United States
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Hospital Oncologico Dr. Isaac Gonzalez-Martinez
Rio Piedras, 00935, Puerto Rico
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National Cancer Center Hospital East
Kashiwa, Chiba, 277-8577, Japan
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Pan American Center for Oncology Trials, LLC
Rio Piedras, 00935, Puerto Rico
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SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
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START Midwest
Grand Rapids, Michigan, 49546, United States
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Sarah Cannon Research Institute - Pharmacy
Nashville, Tennessee, 37203, United States
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The Cancer Institute Hospital of JFCR
Koto, Tokyo, 135-8550, Japan
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Tristar Centennial Medical Center
Nashville, Tennessee, 37203, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new immunotherapy combo outsmart advanced lung cancer?
- A simple screening program could transform cancer aftercare
- Double attack on mutant KRAS: can two targeted drugs outsmart resistant cancers?
- Can new drug cocktails reawaken the immune system against melanoma?
- Seeing the fight: new imaging tracer may reveal how immune cells attack lung cancer
- Could a bronchial wash detect lung cancer mutations faster?