Targeted pill shows promise for rare lung cancer, but trial stopped early

NCT ID NCT04222972

Terminated Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tested a new drug called pralsetinib against standard chemotherapy for people with a specific type of advanced lung cancer that has a RET gene fusion. The goal was to see if pralsetinib could better delay cancer growth. The trial was terminated early, so full results are not available, but the drug is already approved in some countries for this cancer type.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pralsetinib
What this could lead to: If successful, pralsetinib could offer a more targeted, effective first-line treatment option for people with RET fusion-positive lung cancer, potentially improving how long they live without their cancer growing.
What could go wrong: The trial was terminated early, so results are limited. As a targeted therapy, it may only work in people with the specific RET fusion, and side effects or resistance could still occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma bronchial disorder bronchogenic carcinoma carcinoma germ cell tumor head and neck neoplasm Head and Neck Neoplasms lung disorder lung neoplasm neoplasm neoplasm of thorax Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Germ Cell and Embryonal Neoplasms, Nerve Tissue nervous system neoplasm non-small cell lung carcinoma respiratory system disorder respiratory tract neoplasm RET fusion positive cancer Thoracic Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOCARCINOMA BRONCHIAL DISEASES CARCINOMA CARCINOMA, BRONCHOGENIC CARCINOMA, NON-SMALL-CELL LUNG HEAD AND NECK NEOPLASMS LUNG DISEASES LUNG NEOPLASM NEOPLASMS NEOPLASMS BY HISTOLOGIC TYPE NEOPLASMS BY SITE NEOPLASMS, GERM CELL AND EMBRYONAL NEOPLASMS, NERVE TISSUE RESPIRATORY TRACT DISEASE RESPIRATORY TRACT NEOPLASMS RET-FUSION NON SMALL CELL LUNG CANCER THORACIC NEOPLASMS

Contacts and locations

Locations

?zmir Medical Point

Kar?iyaka, 35575, Turkey (Türkiye)
A.O.U. INTEGRATA DI VERONA-Ospedale Civile Maggiore Borgo Trento

Verona, Veneto, 37126, Italy
AZ. Ospedaliera San Giovanni - Addolorata

Rome, Lazio, 00184, Italy
Adana City Hospital, Medical Oncology

Adana, 01060, Turkey (Türkiye)
Ankara Bilkent City Hospital

Ankara, 06490, Turkey (Türkiye)
Asan Medical Center

Seoul, 05505, South Korea
Asklepios-Fachkliniken Muenchen-Gauting

Gauting, 82131, Germany
Azienda Ospedaliera Universitaria Pisana - Ospedale Cisanello

Pisa, Tuscany, 56124, Italy
CHRU Lille Service de Pneumologie et Oncologie Thoracique

Lille, 59000, France
CHU Strasbourg - Nouvel Hopital Civil

Strasbourg, 67091, France
CHU de Toulouse - Hôpital Larrey

Toulouse, 31100, France
Centro Oncologico Riojano Integral (CORI)

La Rioja, F5300COE, Argentina
Christie Hospital Nhs Trust

Manchester, M2O 4BX, United Kingdom
Clinica CIMCA

San José, 10103, Costa Rica
Complejo Hospitalario Universitario A Coruña

A Coruña, LA Coruna, 15006, Spain
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Lombardy, 20133, Italy
Guys & St Thomas Hospital

London, SE1 9RT, United Kingdom
Health Pharma Professional Research

Mexico City, Mexico CITY (federal District), 03100, Mexico
Hemato Oncología de Panamá Especializada

Panama City, 0801, Panama
Hopital Bichat Claude Bernard

Paris, 75018, France
Hopital Tenon

Paris, 75970, France
Hopital de Pontchaillou

Rennes, 35033, France
Hosp Clinico Univ Lozano Blesa

Zaragoza, 50009, Spain
Hospital A. C. Camargo

São Paulo, São Paulo, 01509-010, Brazil
Hospital Britanico

Buenos Aires, C1280AEB, Argentina
Hospital General Universitario Gregorio Marañon

Madrid, 28007, Spain
Hospital Ramon y Cajal

Madrid, 28034, Spain
Hospital Regional Universitario de Malaga

Málaga, 29010, Spain
Hospital Sao Lucas - PUCRS

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain
Hospital de Madrid Norte Sanchinarro- Centro Integral Oncologico Clara Campal

Madrid, 28050, Spain
Hôpital Ambroise Paré - Boulogne-Billancourt

Boulogne-Billancourt, 92100, France
Hôpital Louis Pradel, Hospices Civils de Lyon

Bron, 69677, France
IOV - Istituto Oncologico Veneto - IRCCS

Padova, Veneto, 35128, Italy
IPO do Porto

Porto, 4200-072, Portugal
IRCCS Giovanni Paolo II Istituto Oncologico

Bari, Apulia, 70124, Italy
Ico Rene Gauducheau

Saint-Herblain, 44805, France
Insititut Catala D'Oncologia

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Institut Bergonie CLCC Bordeaux

Bordeaux, 33000, France
Institut Gustave Roussy

Villejuif, 94805, France
Institut Paoli Calmettes

Marseille, 13273, France
Irccs Ospedale San Raffaele

Milan, Lombardy, 20132, Italy
Istituto Europeo Di Oncologia

Milan, Lombardy, 20141, Italy
Istituto Nazionale Tumori Regina Elena

Rome, Lazio, 00144, Italy
Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale

Naples, Campania, 80131, Italy
Juntendo University Hospital

Tokyo, 113-8431, Japan
Kansai Medical University Hospital

Osaka, 573-1191, Japan
Karolinska Universitetssjukhuset, Solna

Stockholm, 171 76, Sweden
Klinik Schillerhöhe

Stuttgart, 70376, Germany
Kyushu University Hospital

Fukuoka, 812-8582, Japan
Leicester Royal Infirmary

Leicester, LE1 5WW, United Kingdom
Leopoldina-Krankenhaus Medizinische Klinik II

Schweinfurt, 97422, Germany
Maastricht University Medical Center

Maastricht, 6229 HX, Netherlands
NKI/AvL

Amsterdam, 1066 CX, Netherlands
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad

Warsaw, 02-781, Poland
National Cancer Center

Goyang-si, 10408, South Korea
National Hospital Organization Himeji Medical Center

Hyōgo, 670-8520, Japan
National Hospital Organization Yamaguchi - Ube Medical Center

Yamaguchi, 755-0241, Japan
Osaka International Cancer Institute

Osaka, 541-8567, Japan
Oslo universitetssykehus HF, Ullevål, Kreftsenteret

Oslo, 0450, Norway
Ospedale Clinicizzato SS Annunziata

Chieti, Abruzzo, 66100, Italy
Ospedale Provinciale Santa Maria Delle Croci

Ravenna, Emilia-Romagna, 48100, Italy
Pius-Hospital

Oldenburg, 26121, Germany
Royal Marsden Hospital

London, SW3 6JJ, United Kingdom
Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
St. James Hospital

Dublin, D08 HNY1, Ireland
The Cancer Institute Hospital of JFCR

Tokyo, 135-8550, Japan
UZ Antwerpen

Edegem, 2650, Belgium
UniversitätsSpital Zürich

Zurich, 8091, Switzerland
Universitätsklinikum Carl Gustav Carus, Medizinische Klinik I, Pneumologie MK1-A13

Dresden, 01307, Germany
Velindre Cancer Centre

Cardiff, CF14 2TL, United Kingdom

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