Bronchial disorder

This study tests a drug called depemokimab in 150 adults with severe asthma caused by a specific type of inflammation. The goal is to see if the drug can reduce mucus plugs and airway thickening in the lungs. Participants will receive the drug and have lung scans and breathing te…

This study tests a smartphone app called SMART@Home designed to help teenagers with asthma manage their condition. The app sends daily reminders for medication and diary entries, provides educational content, and connects to Bluetooth devices like a spirometer to track lung funct…

This study tests an experimental drug called AZD0292 in 435 people aged 12 and older who have bronchiectasis and a long-term lung infection with Pseudomonas aeruginosa. The goal is to see if the drug can reduce the number of moderate-to-severe lung flare-ups compared to a placebo…

This study tests a new drug called GSK3862995B in 446 adults with bronchiectasis, a long-term lung condition. The goal is to see if the drug can reduce the number of serious lung infections (exacerbations) compared to a placebo. Participants will receive either one of two doses o…

This study tests a new drug, firmonertinib, against two standard treatments for people with advanced non-small-cell lung cancer that has certain rare genetic changes (EGFR PACC mutations). About 480 participants who have not had prior treatment for advanced disease will be random…

This study looks at the long-term safety and effectiveness of an oral drug called KT-621 in people with asthma. Participants have already completed a previous KT-621 asthma study. The goal is to see how well the drug works over time and if any side effects appear with longer use.

This study tests an oral drug called KT-621 in 264 adults with moderate to severe eosinophilic asthma that is not well controlled by current treatments. Participants will take either KT-621 or a placebo daily for several weeks. Researchers will measure changes in lung function an…

This early-stage study tests a new experimental drug, PF-08103402, for the first time in people. It includes healthy adults and adults with mild-to-moderate asthma to check safety, how the drug moves through the body, and whether food affects its absorption. Participants take the…

This study tests a dog allergy immunotherapy called Alutard SQ Dog in 40 adults with moderate-to-severe dog allergy. Participants receive increasing doses over 13 weeks, then maintenance shots every 6-8 weeks for a year. Their symptoms and lung function are measured before and af…

This phase 2 trial tests a personalized therapy called LN-145, made from a patient's own tumor-fighting immune cells. Researchers take a sample of the tumor, grow the immune cells in a lab, and then infuse them back into the patient after a short course of chemotherapy. The goal …

This study tests whether a single dose of a nasal spray called ETH47 can reduce asthma symptoms caused by a common cold virus (rhinovirus). Fifty adults with stable asthma will receive either the spray or a placebo and then be exposed to the virus in a controlled setting. Researc…

This study tests whether tezepelumab, an injectable drug, can reduce severe asthma attacks in children aged 5 to 11 with hard-to-control asthma. About 231 kids will receive either tezepelumab or a placebo, alongside their usual asthma medicines. The main goal is to see if the dru…

This study tests whether adding a spacer device to standard triple inhaler therapy can reduce serious flare-ups in older adults (65+) with asthma or COPD who are at high risk. 380 participants will either use the spacer with their inhaler or stick with the inhaler alone. The goal…

This study tests whether a new propellant (HFA-152a) in salbutamol inhalers works as well as the current one (HFA-134a) for people with mild asthma. 84 adults aged 18-65 will receive single doses of the inhaler or a placebo. The main goal is to measure how well the inhaler protec…

This study compares a new version of an asthma inhaler that uses a climate-friendly propellant to the current version. About 780 adults with mild to moderate asthma will try both inhalers to see if they work equally well. The goal is to ensure the greener option is just as effect…

This phase 3 trial tests a new inhaler that combines fluticasone (an anti-inflammatory) and albuterol (a fast-acting bronchodilator) for people 12 and older with asthma. Over 4 weeks, researchers will measure lung function and safety in 724 participants. The goal is to see if the…

This study tests whether depemokimab, an injected biologic drug, can reduce severe asthma attacks and help patients achieve remission when added to standard care. About 456 adults and adolescents with type 2 asthma at risk of flare-ups will receive either depemokimab or a placebo…

This study tests a daily pill called BI 1291583 (Verducatib) in 1755 adults and teens with bronchiectasis, a lung condition causing frequent infections and coughing. Participants take either the drug or a placebo for up to 76 weeks. The main goal is to see if the drug reduces the…

This study tests whether school-based health centers can improve asthma care for 400 children with uncontrolled asthma from underserved communities. The program includes guideline-based assessments, directly observed preventive medication, and self-management support. The goal is…

This phase 3 trial is testing whether people with severe asthma who take the drug Tezepelumab can safely cut back on their other daily asthma medications without losing control of their symptoms. About 400 participants aged 12 to 80 will be enrolled. The goal is to see if they ca…

This study follows 300 adults with severe eosinophilic asthma who are prescribed benralizumab as part of their normal care in Germany. Researchers will track changes in asthma control, lung function, and medication use over one year. The goal is to see how the drug performs outsi…

This study tests whether an inhaled drug called LQ036 can improve lung function and asthma control in people whose asthma is not well managed with current treatments. About 216 participants will inhale the drug or a placebo once daily for 24 weeks. The main goal is to see if LQ03…

This study tests whether the experimental drug brenipatide can reduce asthma attacks and improve breathing in adults whose moderate-to-severe asthma is not well controlled by current treatments. About 531 participants will receive either brenipatide or a placebo for 52 weeks. The…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This phase II trial tests whether a radioactive drug called lutetium Lu 177 dotatate works better than the usual drug everolimus for people with advanced bronchial neuroendocrine tumors (a type of lung cancer). The radioactive drug targets a protein on tumor cells and delivers ra…

This study tests whether weekly phone calls with education, relaxation techniques, and motivational interviewing can help adults with asthma who are anxious about using their inhalers. 216 participants will be split into two groups: one gets the extra phone support, the other get…

This global study is testing whether adding the experimental drug olomorasib to standard immunotherapy and chemotherapy can help people with a specific genetic subtype of advanced non-small cell lung cancer (KRAS G12C mutation). About 1,264 participants will receive either the ne…

This study tests an experimental drug called SAR445399 in 70 adults aged 18-80 with non-cystic fibrosis bronchiectasis, a lung condition causing mucus buildup and infections. Participants receive either the drug or a placebo for 24 weeks to see if it reduces mucus plugs seen on C…

This Phase 3 trial tests an injectable drug called TQC2731 in 660 adults with severe asthma that is not well controlled by high-dose inhalers. Participants will receive either the drug or a placebo every 4 weeks for a year. The goal is to see if the drug reduces asthma attacks an…

This trial tests whether a 6-month personalized exercise program improves exercise capacity and asthma control in adults with severe asthma who are starting biologic therapy. Participants are randomly assigned to either the exercise program or standard advice to increase physical…

This study tests a new treatment called IOV-4001 for people with advanced melanoma or non-small-cell lung cancer. The treatment uses a patient's own tumor-fighting immune cells, which are collected, genetically modified to remove a 'brake' called PD-1, and then infused back after…

This study follows 335 adults with severe eosinophilic asthma who are taking benralizumab. Researchers want to see if the drug helps patients achieve partial or complete clinical remission—meaning fewer symptoms, no need for steroid pills, and better lung function—over 12 to 24 m…

This phase 3 trial tests whether GB-0895, given every 6 months, can reduce asthma attacks in adults and teens (ages 12–80) with severe asthma that isn't controlled by standard inhalers. About 786 participants will receive either GB-0895 or a placebo, and researchers will track ho…

This study tests whether a device called SIMEOX, used at home with remote physiotherapy, can improve quality of life and reduce lung infections in people with bronchiectasis (a chronic lung disease with mucus buildup). About 622 adults will use the device daily or get standard ca…

This study tests a new inhaler (PT027) against a standard one (PT007) in 440 teens aged 12 to 18 with asthma. The goal is to see if PT027 reduces the number of severe asthma attacks over a year. Participants must have had at least one severe attack in the past year and use daily …

This study tests a new once-daily inhaler called QMF149 (a combination of indacaterol and mometasone) against a standard asthma drug, budesonide, in 200 children aged 6 to 12 with asthma. The goal is to see if the new drug works better at improving lung function and controlling a…

This study tests whether low-cost fixes for dampness and mold in the home can improve asthma control in children from low-income families. About 80 kids with asthma will be split into two groups: one gets the home repairs right away, the other waits. Researchers will check asthma…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps (with or without asthma). About 110 people will be followed for up to a year to see if their nasal polyps shrink and congestion improves. The goal is to understand real-world benefit…

This study tests whether benralizumab, an injected drug, can reduce asthma attacks in children aged 6 to 17 with severe eosinophilic asthma. About 200 participants will receive either benralizumab or a placebo, and researchers will track how long it takes for their first asthma f…

This study tests the safety of a drug called HSK31858 in 669 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes repeated infections and breathing problems. Participants who completed a prior study of the same drug will receive the medication and be monit…

This study is for people with a specific type of lung cancer (EGFR-mutant) that has spread to other parts of the body after they finished a previous treatment (osimertinib). The goal is to see if combining osimertinib with chemotherapy can help control the cancer for longer. Abou…

This study will give HEPA air cleaners to 55 children (ages 7-18) with asthma living in low-income housing in East Harlem, NYC. Researchers will measure indoor air pollution and track asthma attacks, lung function, and airway inflammation over a year. The goal is to see if a simp…

This study tests a new drug called tozorakimab in 540 adults with uncontrolled asthma despite using medium-to-high dose inhaled steroids. Participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if tozorakimab can reduce the number …

This pilot study is testing whether the antifungal drug itraconazole is feasible and safe for people with bronchiectasis who have mold growing in their airways. Thirty participants will take itraconazole twice daily for six weeks. The study will measure how many people complete t…

This study tests a new drug called repotrectinib in people with advanced solid tumors that have certain gene changes (ALK, ROS1, or NTRK). The trial has two parts: first, finding a safe dose, and second, seeing how well the drug shrinks tumors. About 500 adults with advanced canc…

The ATHENA Project is testing a mobile health program designed to help African American young adults (ages 18-30) better control their asthma. Participants use a web-based app, have video chats with an asthma nurse, receive text messages, and track physical activity. The study ai…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This phase 3 study tests whether an inhaler combining budesonide (a steroid) and albuterol (a rescue drug) works better than albuterol alone for preventing severe asthma attacks. About 790 Chinese adults with asthma who have had at least one severe attack in the past year will us…

This study tests a new medicine called GB-0895 for people aged 12 to 80 with severe asthma that is not controlled by standard inhalers. Participants receive either GB-0895 or a placebo as a shot every 6 months for a year. The goal is to see if GB-0895 can reduce the number of ser…

This study tests a new drug called [212Pb]VMT-α-NET, which delivers a powerful type of radiation (alpha particles) directly to tumor cells that have a specific marker (SSTR2). The trial includes 300 adults with advanced neuroendocrine tumors or meningioma that cannot be removed b…

This phase 3 trial is testing whether adding benralizumab (an injectable drug) to medium-dose inhalers can reduce asthma attacks in people with eosinophilic asthma whose symptoms are not well controlled. About 400 participants aged 12 to 75 will be randomly assigned to receive be…

This study tests an inhaled drug called ensifentrine in 284 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes frequent infections and breathing problems. Participants will receive either the drug or a placebo twice daily for at least 24 weeks. The goal …

This study tests whether having school staff supervise children taking their asthma medication can improve symptoms and reduce hospital visits. About 350 children aged 5-14 with poorly controlled asthma will either receive school-supervised therapy plus an educational workbook, o…

This study tests a program called TEACH-ER that provides asthma education in the emergency room and virtual follow-up visits at home. Researchers will enroll 430 children aged 3-12 with asthma to see if this approach reduces the need for future ER visits or hospital stays. The pr…

This study explores whether using connected inhalers that track medication use, combined with video doctor visits when problems arise, can manage childhood asthma as well as standard in-person care. Fifty children aged 4 to 12 with asthma will take part for 8 months. Half will us…

This study tests a new medicine called PF-07275315 for adults with moderate-to-severe asthma that is not well controlled. Participants will receive either the drug or a placebo as injections over 12 weeks. The goal is to see if the drug improves lung function and is safe. About 2…

This study tests a program called PRAGMATIC-S that connects doctors' offices with schools to help children ages 4-12 better manage their asthma. The goal is to improve asthma control and quality of life by making sure kids get the right care in both places. About 420 children wit…

This Phase 3 trial tests an injectable drug called CM326 in 230 adults with moderate to severe asthma. The goal is to see if it can reduce the number of severe asthma attacks over one year. Participants will receive either CM326 or a placebo, and researchers will also measure cha…

This study tests whether a special education program called 'Asthma School' can help adults with asthma have fewer flare-ups and avoid emergency room visits or hospital stays. About 92 participants will be split into two groups: one that attends the school and one that gets usual…

This phase 2 trial tests whether combining the immunotherapy drug cemiplimab with either chemotherapy or targeted radiation (SBRT) before surgery can eliminate or shrink non-small cell lung cancer more effectively. About 112 people with stage IB to III (N2) lung cancer will recei…

This study tests two experimental drugs, elironrasib and daraxonrasib, given alone or together, in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drugs are safe and can shrink or control the cancer. About 534 adults with lung,…

This study tests whether adding an extra medication called glycopyrronium to standard asthma treatment can improve lung function in children aged 4 to 12. About 69 children with asthma will receive two different doses of glycopyrronium or a placebo, all on top of their usual inha…

This study tests a drug called benralizumab (Fasenra) in 20 adults with severe asthma and a fungal allergy called ABPA. The goal is to see if it can reduce asthma flare-ups that need steroids and improve quality of life. Participants receive the drug as a shot under the skin, and…

This study tests whether giving adults with acute asthma a specific rescue inhaler (Airsupra) right in the emergency department can reduce the chance of another asthma attack within 3 months. About 1,860 participants will either receive Airsupra or continue usual care. The goal i…

This study tests a device called BiWaze Clear that helps people with bronchiectasis clear mucus from their lungs using gentle vibrations and lung expansion. About 85 participants will use the device at home for 6 months. Researchers will track how many lung infections they get co…

This study tests an experimental drug called povorcitinib in 240 adults with moderate to severe asthma that is not well controlled by current treatments. Participants will receive one of three doses of the drug or a placebo for 24 weeks. The main goal is to see if the drug improv…

This study tests two school-based programs to help children aged 5-12 with asthma in low-income communities. The goal is to reduce asthma attacks and missed school days. Researchers will enroll 300 children across rural Colorado schools and compare a standard program to an enhanc…

This study aims to see which of two triple-combination inhalers works better for people with moderate to severe asthma that is not well controlled. About 20 adults will try both Trimbow and Trelegy Ellipta in a crossover design, and researchers will use special MRI scans to measu…

This study tracks 600 adults with asthma who are already prescribed Enerzair inhaler. Over 24 weeks, researchers will monitor side effects and how well the drug controls asthma in everyday life. No new treatment is given; it simply observes routine care.

This study tests an experimental drug called SIM0718 for people with asthma that is not well controlled by current inhalers. About 418 adults and teens aged 12 to 75 will receive either the drug or a placebo for one year. The main goal is to see if the drug reduces the number of …

This study tests whether astaxanthin, a natural antioxidant supplement, can improve lung function and reduce airway inflammation in adults with mild-to-moderate asthma. Participants will take astaxanthin and a placebo in random order for 4 weeks each, with a break in between. The…

This study tests whether a new digital spacer (Whizz) helps children aged 5-16 with asthma use their inhaler correctly and stick to their medication, compared to a standard spacer. Researchers will also look for biomarkers in blood and breath to improve diagnosis and understand h…

This study tests two doses of an inhaled drug called glycopyrronium in 42 children aged 6 to 12 with moderate to severe asthma. The goal is to see how well it opens airways and how safe it is compared to a placebo. Results will help decide the best dose for future combination tre…

This study follows 200 adults with uncontrolled asthma to see if the Trimbow inhaler (a triple-combination drug) improves symptom control over 6 months. Participants take the inhaler as part of their normal care, and researchers measure changes in asthma control scores and medica…

This study tests a nasal spray called RIG-101 in healthy people and those with asthma. First, it checks safety and tolerability. Then, asthma participants receive the spray daily and are exposed to a cold virus to see if it prevents asthma worsening. The trial is recruiting 82 ad…

This study tests whether using a blood test that measures eosinophil levels can help doctors tailor asthma treatments more effectively than standard care. About 240 adults with mild to moderate asthma will be followed for one year. The goal is to see if this approach reduces asth…

This study tests if dupilumab, an injected drug, can help control asthma and severe wheezing in children aged 2 to 6. About 90 kids will receive either dupilumab or a placebo for a year, with an option to continue treatment. The goal is to see if it reduces serious asthma attacks…

This study tests whether a trained asthma navigator can help children aged 4-12 avoid repeat hospital visits after an asthma attack. Families in the Washington, DC area will be randomly assigned to receive either standard care or extra support from a navigator for 12 months. The …

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests whether the medication dupilumab can help people with moderate asthma achieve complete control (remission) when given early, before the disease becomes severe. About 150 adults aged 18-79 with moderate asthma and high inflammation markers will receive either dupi…

This study tests whether adding soluble fiber (inulin) to the diet can improve asthma control in children aged 6 to 17. Participants will take a fiber or placebo drink for several weeks. Researchers will check asthma symptoms and analyze gut and nasal microbes to see if diet chan…

This study is observing 225 adults with severe allergic asthma or chronic hives who are already doing well on the original omalizumab drug. Their doctors have decided to switch them to a biosimilar version called Omlyclo. The main goal is to see if they stay well-controlled for 1…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This study looks at two standard treatments for early-stage lung cancer: surgery and a precise type of radiation called stereotactic radiotherapy. About 670 veterans with stage I non-small cell lung cancer will take part. The goal is to see which treatment leads to longer surviva…

This trial tests two ways of using a breathing machine during surgery in 200 adults at high risk for lung complications. One method uses standard protective settings, while the other adjusts the machine based on each patient's lung stiffness. Researchers will track lung problems,…

This study tests a short, scripted conversation between doctors and Black adults with uncontrolled asthma. The goal is to help patients and doctors make decisions together about asthma medicines. Researchers will enroll 400 adults at community health centers to see if this approa…

This phase 2 trial tests whether escitalopram, an FDA-approved antidepressant, can reduce severe asthma flare-ups in people with moderate to severe asthma who have had at least three attacks in the past year. About 105 participants will receive either escitalopram or a placebo pi…

This study tests an experimental drug called LP-003 in 200 adults with moderate to severe allergic asthma. The goal is to see if it reduces asthma attacks and improves breathing compared to a placebo or an active drug. Participants receive injections and are monitored for about a…

This study tests whether using one inhaler (budesonide/formoterol) for both quick relief and daily control can reduce asthma attacks in children ages 6-18 in South Africa. About 1,038 kids with asthma will be split into two groups: one gets the single inhaler, the other gets sepa…

This study tests whether metformin, a common diabetes medication, can improve asthma control in overweight or obese adults whose asthma is not well-managed by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks while tracking their …

This study tests a program to help doctors at community health centers prescribe a recommended asthma treatment called SMART (Single Maintenance and Reliever Therapy). The program includes training, feedback, and educational tools for both doctors and patients. Researchers will m…

This study tests whether a new drug, FB825, can help adults with moderate-to-severe allergic asthma. About 100 participants will receive either FB825 or a placebo. The main goal is to see if FB825 reduces asthma attacks over 24 weeks.

This study tests a new corticosteroid inhaler called PA9159 in 60 adults with asthma. Participants receive one of three doses or a placebo for 28 days. The main goal is to see if the drug improves lung function, measured by how much air they can exhale in one second. The trial is…

This study tests a new asthma inhaler called PA9159 in 30 adults with asthma. The goal is to see if it improves lung function and is safe over 4 weeks. Participants will use the inhaler and have their breathing measured regularly.

This Phase 3 trial tests a new drug called 610 in 480 Chinese adults with severe eosinophilic asthma, a type of asthma linked to high levels of certain white blood cells. Participants receive either 610 or a placebo injection for 52 weeks. The main goal is to see if 610 reduces t…

This study tests whether training the muscles used to breathe in can improve exercise capacity, quality of life, and short-term outcomes in people who have had a lung transplant. Thirty participants will use a device called POWERBreathe Plus® along with standard rehab. The goal i…

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study is testing whether placing a temporary intragastric balloon (a soft balloon in the stomach) along with diet and exercise can improve asthma control in obese people whose asthma is not well managed by inhalers. About 84 participants will be randomly assigned to get the …

This study tests a procedure called bronchial thermoplasty (BT) for adults with severe asthma that remains uncontrolled even with biologic drugs. BT uses a thin tube to deliver heat to the airway walls, aiming to reduce muscle overreactivity. Researchers will compare asthma attac…

This phase 2 study tests a new drug called SHR-1703, given as multiple injections under the skin, for people with eosinophilic asthma. The goal is to see if it is safe and helps control asthma over the long term. About 200 adults will take part, and researchers will monitor side …

This study tests whether azithromycin, an antibiotic, can reduce airway inflammation in children ages 3-17 hospitalized for critical asthma. One hundred participants will receive the drug for three days while researchers monitor inflammation markers and side effects. The goal is …

This study tests whether the drug vimseltinib is safe and effective for adults with moderate to severe chronic graft-versus-host disease (cGVHD) who have not improved after at least two prior treatments. About 48 participants will take vimseltinib daily for up to two years. The g…

This study tests a new medicine called SHR-1703 to see if it can reduce asthma attacks in people with eosinophilic asthma, a type of asthma linked to high levels of certain white blood cells. About 400 participants aged 12 and older who already use daily inhaled steroids and othe…

This study tests whether using a CPAP machine at night can help people with severe uncontrolled asthma who also have obstructive sleep apnea. Researchers will compare asthma control, lung function, and quality of life between those who receive CPAP plus lifestyle advice and those…

This study tests a program called CHAMPION that helps children with overweight or obesity and asthma live healthier lives. The program includes doctor visits, diet advice, and health coaching. Researchers want to see if doing the program entirely online works as well as meeting i…

This study is testing whether the drug dupilumab can improve how well the lungs clear mucus in people with moderate-to-severe asthma. Thirty adults will receive either dupilumab or a placebo for 12 weeks. Researchers will measure mucus clearance using a special imaging technique,…

This study tests an inhaled medicine called CSL787 in adults with non-cystic fibrosis bronchiectasis, a lung condition that causes frequent infections and breathing problems. The goal is to see if CSL787 can delay the time until a person's next lung flare-up (exacerbation) compar…

This study tests whether installing energy recovery ventilators or portable air cleaners in low-income homes can reduce indoor pollutants and mold, and improve asthma control. Researchers will monitor 80 households over one year, measuring lung function, asthma symptoms, and qual…

This study tests two ways to prevent asthma attacks: using inhaled steroids as a rescue inhaler (R-ICS) or taking azithromycin regularly. Researchers want to see which works better, alone or together, for people with poorly controlled asthma. About 3,200 people aged 13-75 with as…

This study tests whether a triple-combination inhaler (containing three drugs) works better than a standard dual-combination inhaler for teenagers aged 12-17 whose asthma is not well controlled. About 292 participants will use either the triple or dual inhaler daily for 24 weeks.…

This study tests whether a mobile app, inhaler sensors, and remote coaching from an asthma coordinator can help children ages 4-17 better manage their asthma. Eighty parent-child pairs will be split into two groups: one gets the full digital toolkit with coaching, the other gets …

This phase 3 trial tests a new drug called SHR-1905 for adults with severe asthma that is not well controlled by current treatments. The study will compare the drug to a placebo to see if it reduces asthma attacks and improves lung function. About 408 participants will take part …

This study tests two ways to reduce cockroach allergens in homes of children with asthma in New Orleans. One group gets a simple cockroach bait, the other gets a tailored plan including education, mattress covers, and air purifiers. Over 12 months, researchers will track asthma s…

This study is testing whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will exercise 40-60 minutes, five times a week, for eight weeks, doing activities like brisk walking, jogging,…

This study is testing whether a smart inhaler cap and mobile app can help adults with poorly controlled asthma use their inhaler correctly and take their medication as prescribed. Sixty participants will use the smart system for one year while continuing their usual asthma treatm…

This study will test a handheld ultrasonic spirometer against a conventional hospital spirometer in 100 adults with chronic respiratory diseases like COPD or asthma. Each participant will use both devices to see if the portable one gives accurate and reliable results. If successf…

This study aims to see if a portable device that measures lung function can accurately diagnose asthma in people with symptoms like wheezing or coughing. Researchers will compare this new test to the standard breathing tests currently used. The study plans to enroll 500 adults ac…

This study is testing a device called fenoTRACK that measures a gas in your breath linked to airway inflammation. It aims to see if the device can accurately track asthma control in both children and adults, whether used at home or in a clinic. The study includes people with unco…

This study is testing whether two simple breathing tests—oscillometry and FeNO—can help primary care doctors accurately diagnose asthma and COPD, compared to the usual specialist methods. Researchers will enroll 600 adults with suspected asthma or COPD across six countries. If th…

This study is enrolling 200 adults with asthma or COPD to see if combining chest CT scans with blood, sputum, and microbiome tests can more accurately tell the two diseases apart. Researchers will also look for clues that predict how well a patient will respond to treatment. No e…

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study is testing whether two simple, non-invasive tests—a breath test (FeNO) and a blood test (eosinophil count)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires complex hospital-based breathing tests. The researchers aim t…

This study evaluates the Breathing Pattern Assessment Tool (BPAT), a checklist used by physiotherapists to diagnose breathing pattern disorder—a condition where breathing is inefficient, causing breathlessness. Researchers will compare BPAT scores with patient questionnaires and …

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study looks at whether measuring inflammation in the breath and blood can help doctors prioritize who gets lung tests first when asthma is suspected. About 1,500 people aged 6 and older will take part. The goal is to see if this approach reduces delays for those most at risk…

This study tests a wearable device called the C-mo System that automatically detects and describes coughs. Researchers want to see if it can accurately count coughs, measure their intensity, and identify wheezing. 300 people aged 2 and older with cough-related conditions will wea…

This study tests a new device that uses artificial intelligence to help diagnose ear infections, strep throat, and asthma flare-ups in children. About 84 kids aged 3 to 17 will either use the device at home with a doctor's video visit or receive standard in-person care. The goal …

This study explores whether a lung ultrasound can safely detect rejection or infection in lung transplant recipients who have no symptoms. Currently, patients need an invasive bronchoscopy with biopsy to check for rejection. If ultrasound works, it could offer a faster, safer, an…

This study tests a non-invasive imaging method called electrical impedance tomography (EIT) to monitor lung function in 400 adults with lung diseases like COPD, asthma, or pneumonia. Unlike standard spirometry, which requires active blowing, EIT works even in patients who cannot …

This study aims to find people who have asthma or COPD but don't know it yet. Participants will take an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal is t…

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study tests a small wearable device called AeviceMD that listens to lung sounds and detects wheezing. Researchers want to see if the device is as accurate as a doctor using a stethoscope. About 160 children and adults with asthma will participate. If successful, the device c…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests whether an eHealth app can help parents of children under 6 reduce their kids' exposure to second-hand smoke. About 160 families will use the app or receive standard care. The goal is to lower children's urine cotinine levels and prevent asthma and other diseases…

This study tests whether giving a soy isoflavone supplement to infants at high risk for asthma can reduce their chance of developing the condition. Researchers will give 65 babies either the supplement or a placebo twice daily for 7 months, tracking wheezing episodes and immune m…

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The trial will enroll 2000 pregnant Danish women with low blood levels of omega-3s. Participants take fish oil or placebo capsules d…

This study is testing whether taking a higher dose of vitamin D during pregnancy can prevent asthma and persistent wheezing in children up to age 3. Researchers will give 2000 pregnant women either vitamin D or a placebo daily from week 22-26 of pregnancy until one week after del…

This early-stage study tests a single dose of an experimental drug called CDX-622 in 12 adults with mild to moderate asthma. The main goal is to see if the drug is safe and to measure how it affects markers of airway inflammation. Participants will be monitored for side effects a…

This Phase 3 trial tests whether the drug Raphamin can help adults with acute bronchitis recover faster. About 308 participants will take either Raphamin or a placebo for 5 days. Researchers will track symptoms like cough and chest pain to see if Raphamin reduces illness duration…

This study tests an inhaled medication called ARO-RAGE in 36 adults with mild asthma that is triggered by allergens. The goal is to see if it improves small airway function after breathing in an allergen. Participants will receive either the drug or a placebo and be monitored for…

This study is testing whether eating a soft chew containing plant stanols every day can reduce asthma symptoms in people with allergic asthma. Plant stanols are known to lower cholesterol, but they may also shift the immune system away from the type of response that triggers asth…

This early-stage trial tests a single inhaled dose of ASY202, a drug containing dihydroergotamine, in 40 adults with stable asthma. The study is randomized and placebo-controlled, meaning some participants get the drug and some get an inactive powder. The main goal is to check sa…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study tests whether inhaling a salty mist (3% hypertonic saline) can improve breathing symptoms in people with nontuberculous mycobacterial (NTM) lung disease who haven't yet started antibiotics. About 262 adults will either start the saltwater treatment right away for 6 mon…

This study tests whether adding hand acupuncture to standard medicine can quickly improve breathing during an asthma flare-up. Researchers will measure lung function and symptom scores in 72 adults over 5 days. The goal is to see if acupuncture offers a new, drug-free option for …

This early-stage study tests an inhaled drug called GDC-6988 in people with lung conditions that cause thick mucus, like non-CF bronchiectasis and COPD. The main goal is to check if the drug is safe and tolerable. About 128 adults with stable disease and good lung function will t…

This study tests whether wearing N95 masks while golfing on smoky days helps protect lung health. Forty regular golfers will wear masks when air pollution is moderate or higher during wildfire season. Researchers will measure how often they wear the masks and check their lung fun…

This study compares two types of aerobic exercise for children with asthma: virtual reality-based games and treadmill walking. Thirty children aged 10-17 will exercise twice a week for 8 weeks. Researchers will measure lung function, exercise capacity, and quality of life to see …

This study tests a new education program called WASP that teaches adults with asthma how to manage their condition day-to-day. The goal is to see if it helps control symptoms and improves quality of life. Forty adults will take part through their GP or primary care clinic.

This study tests two simple ways to reduce fear in children aged 3-6 who need breathing treatments (nebulization) for conditions like asthma. One group uses a toy-shaped nebulizer, another uses colorful distraction cards with games, and a third group gets standard care. Researche…

This study is testing a serious video game designed to improve emotional well-being in teenagers aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to personalize activities that build coping …

This study compares two ways to help people with bronchiectasis breathe easier during a sudden worsening of their condition. Twenty patients in the ICU will receive either a high flow nasal cannula or non-invasive ventilation. Researchers will measure how long patients stay in th…

This study compares two approaches to supportive cancer care for nearly 3,000 adults with cancer. One group gets information through email or their health record, while the other works one-on-one with a lay health worker over 12 months. The goal is to see which model better impro…

This study tests an experimental oral drug called ENV-294 in 50 adults with moderate-to-severe asthma who already use standard inhalers. Participants take either the drug or a placebo once daily for 12 weeks. The goal is to see if the drug improves asthma control and lung functio…

This study compares two different doses of the steroid dexamethasone (0.3 mg/kg vs. 0.6 mg/kg) given by mouth to children aged 4-15 who come to the emergency department with an asthma attack. The goal is to see which dose works better at reducing the need for another steroid pres…

This study looks at whether moderate aerobic exercise can improve fitness, quality of life, and asthma symptoms in adults with persistent asthma. About 100 participants will follow a supervised exercise program for 3 months. The goal is to see if exercise can be a helpful additio…

This study compares two breathing exercises—alternate nostril breathing and Buteyko breathing—in 46 adults with mild to moderate asthma. The goal is to see which technique better improves breath control, reduces shortness of breath, and boosts lung function. Participants will pra…

This study follows 200 adults with bronchiectasis who use the LibAirty airway clearance system at home as part of their regular care. Researchers want to see how often lung flare-ups happen over a year. Participants fill out short questionnaires and have their medical records rev…

This study looks at two types of exercise—energy conservation exercises and circuit training—to see which one better helps people with asthma manage shortness of breath, improve physical ability, and boost quality of life. About 32 adults with mild-to-moderate asthma will take pa…

This study tests a new drug called PRA-216 in two phases. First, healthy volunteers receive single or multiple doses to check safety. Then, people with mild-to-moderate asthma receive the drug to see if it reduces airway inflammation and improves asthma control. The goal is to fi…

This study is testing whether a structured exercise program called Indonesian Asthma Gymnastic can help adults with stable asthma breathe better and feel better day-to-day. Researchers will measure walking distance, lung function, and asthma control in 35 participants who continu…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This study tests a new method for treating cat allergies called intralymphatic immunotherapy (ILIT), where allergen extracts are injected directly into a lymph node. Thirty-six adults with cat-triggered allergic rhinitis and asthma will receive 3-4 ultrasound-guided injections. T…

This study tests a device called the Lung Master, which is meant to increase lung capacity by practicing slow, deep breaths. Twenty adults with or without breathing conditions will use the device daily at home for one month. Researchers will measure lung function before and after…

This early-stage trial tests the safety of an inhaled study drug called CHF6333. It involves 45 participants: first, healthy volunteers and people with bronchiectasis receive a single dose; then, people with bronchiectasis receive repeated doses. The goal is to check for side eff…

This study tests whether a new device called Simeox, which uses gentle vibrations to loosen mucus without forced breathing, works better than standard chest physiotherapy for people with bronchiectasis. Forty adults with stable disease will try both methods in a crossover design.…

This study is testing whether a natural supplement called 5HTP can improve breathing and reduce anxiety in children aged 8-18 with mild to moderate asthma and allergies. About 20 participants will be randomly assigned to take either 5HTP or a placebo, then switch groups later. Th…

This study looks at whether adding regular walking to a low-calorie diet and metformin can improve lung function and weight in women who have both PCOS and asthma. Forty obese women will be split into two groups: one does exercise plus diet and metformin, the other only diet and …

This study tests whether giving children with asthma and their families Air Quality Index (AQI) information helps improve asthma control. 351 children will receive either EPA or commercial AQI education plus an asthma action plan, or standard care. Over 48 weeks, researchers will…

This study tests whether a short-term therapy called Enhanced Brief Interpersonal Psychotherapy (IPT-B) can reduce depression in mothers of children with asthma. Sixty Black mothers who have mild to moderate depression and a child with asthma will either receive the therapy or us…

This study tests a special breathing exercise program for adults with bronchiectasis, a chronic lung disease that causes coughing and shortness of breath. The program combines breathing muscle training with core-strengthening exercises. Researchers will measure lung function, mus…

This study is testing whether using an oscillating PEP (OPEP) device—a handheld breathing tool that helps clear mucus—can improve quality of life for people with bronchiectasis. Researchers will give questionnaires to 60 children (ages 8+) and adults before and after they start u…

This study tests whether two common antidepressants, duloxetine and amitriptyline, can reduce coughing in people with refractory chronic cough—a cough that persists despite standard treatments. About 50 adults will receive either a low or high dose of one drug or a placebo for 4 …

This study tests a new under-the-tongue treatment (MM09) for people with rhinitis or rhinoconjunctivitis caused by house mite allergy, with or without mild asthma. About 736 participants aged 12 to 65 will receive either MM09 or a placebo to see if it reduces allergy symptoms and…

This study tests a new way to help teenagers with asthma feel more in control of their condition. Teens aged 12-18 will either get a standard doctor visit or a visit where their confidence in managing asthma is assessed and addressed. After three months, researchers will compare …

This study is testing a new interactive digital breathing game designed to help children with bronchiectasis clear mucus from their lungs at home. The game aims to replace the need for a physiotherapist by using a device connected to a phone or computer. The trial will involve 40…

This study tests whether a home-based breathing and respiratory muscle training program, supported by a health coach, can help people with non-cystic fibrosis bronchiectasis improve their exercise ability and lung function. About 50 participants will use a digital program at home…

This study tests a smartphone system called ReACT that helps teens ages 13-17 with poorly controlled asthma. The app tracks medication use and symptoms, and offers personalized tips and goal-setting. 160 teens will be randomly assigned to use ReACT or a basic asthma app for six m…

This study tests whether giving intravenous magnesium (IVMg) early to children aged 2-17 with severe asthma in the emergency room can reduce their breathing distress more than a placebo. About 192 children who still have moderate-to-severe symptoms after initial treatment will re…

This study looks at whether adding specific breathing exercises (Buteyko or Pilates-style) to neck stretches can improve lung function and chest movement in adults with well-controlled asthma who also have forward head posture. Twenty-two participants will be assigned to one of t…

This study tests a new medicine called FB704A in adults with severe asthma. The goal is to see if it is safe and can help control asthma symptoms. About 20 people will receive either the drug or a placebo over 8 weeks, with follow-up for 12 more weeks.

This study tests whether encouraging people with asthma to join an online support group can improve their symptoms and quality of life. 600 adults with poorly controlled asthma will be recruited. Their doctors will introduce them to a private online community where they can read …

This early-stage trial is testing a new drug, IBI3002, in adults with asthma that is not fully controlled by their current inhalers. About 12 to 27 participants will receive either the drug or a placebo by injection to see if it is safe and how the body processes it. The study is…

This study is testing a mobile app called ASTHMAXcel Voice to see if it helps adults with asthma better control their symptoms. The app sends reminders and educational content to users. Two hundred adults with persistent asthma will either use the app or receive usual care, and r…

This study compares two COPD self-management education programs: a self-guided booklet and a counselor-led phone program. Researchers want to see which approach better reduces hospitalizations and improves quality of life. 448 adults with COPD who have been hospitalized in the pa…

This study tests whether a syrup called Atock Dry Syrup can reduce wheezing in children aged 6 months to 12 years with acute bronchitis. About 296 kids will receive either the syrup or a standard patch treatment. The main goal is to see if wheezing improves within 3 days.

This phase 3 trial tests whether a new drug called DW1807 works better than another drug (DW1807-R2) for people with year-round allergic rhinitis who also have asthma. About 274 adults will take one of the two drugs daily for 4 weeks. The main goal is to see if DW1807 improves na…

This study compares two techniques to help people with mild to moderate asthma breathe better: alternate nostril breathing (a type of yoga breathing) and using an incentive spirometer (a device that encourages deep breathing). Researchers will measure lung function and quality of…

This study tests a device that delivers gentle electric pulses to the airways to reduce chronic bronchitis symptoms in adults with COPD. About 210 participants will either receive the real treatment or a sham procedure. The goal is to see if the treatment improves breathing and q…

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study follows 900 people with bronchiectasis—a condition where airways are damaged and prone to infection—to learn why they get sick repeatedly. Researchers will collect medical history, lung function tests, and blood, urine, and sputum samples from patients and their family…

This study follows 310 children aged 6 to 17, some with asthma and some without, for one year. Researchers want to learn how different types of asthma cause symptoms and sudden attacks. Participants keep track of cold symptoms and attend regular check-ups. The goal is to better u…

This study looks at how mucus plugs in the lungs affect breathing in people with severe asthma. Researchers will use special MRI scans to see air flow in blocked areas. Only 5 adults with severe asthma will take part, and the goal is to better understand lung function, not to tes…

This study looks at whether anxiety or depression makes asthma harder to control and aims to build a model that predicts when a serious asthma attack might happen. Researchers will follow 256 people with asthma for up to two years, tracking their symptoms, mental health, and lung…

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This observational study compares how people with bronchiectasis and healthy volunteers respond to different exercise tests, including a 6-minute stepper test, a 6-minute walk test, and a 1-minute sit-to-stand test. Researchers will measure breathing, heart rate, and muscle stren…

This study is observing 5,000 adults in Russia with severe, uncontrolled asthma who are not taking biologic medications. Researchers will collect information on their current treatments, health history, and lifestyle factors. The goal is to better understand how these patients ar…

This study follows 400 adults aged 18–60 with moderate-to-severe asthma for up to 5 years. Researchers collect blood, urine, stool, dust, saliva, and lung samples at regular visits to see how bacteria and other environmental factors affect asthma symptoms and flare-ups. The goal …

This observational study is enrolling 355 adults with asthma in China to describe their clinical features, treatment patterns, and biological markers. Researchers will analyze lung function, imaging, and blood biomarkers to identify distinct asthma subtypes. The goal is to gather…

This study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…

This study follows 300 infants to understand how catching RSV very early (before 4 months old) versus later (after 6-9 months) affects their immune system and long-term health. Researchers will measure antibody responses and track asthma-like symptoms. The goal is to learn why ea…

This study reviews medical records of 500 Polynesian patients with bronchiectasis (widened airways) to understand why the condition is so common in French Polynesia. Researchers will look at age of onset, family history, infections, and CT scan patterns to see if a genetic cause …

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will examine DNA from up to 3,500 people with and without lung disease to find genetic differences. The goal is to better understand what causes these cond…

This study follows 320 Chinese adults with non-cystic fibrosis bronchiectasis (a chronic lung condition causing cough and infections) and some healthy volunteers for 12 months. Researchers will collect lung function tests, blood samples, and imaging to identify biomarkers and dis…

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study looks at how short-term exposure to air pollution affects children's breathing. Around 330 children from London schools will either take a science lesson or do physical education outdoors. Researchers will measure lung function and immune responses to see if exercising…

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This study aims to better understand asthma and COPD by comparing immune markers in blood and airways of patients versus healthy volunteers. Researchers will analyze samples from 230 adults to identify distinct immune patterns linked to disease severity. The goal is to improve di…

This study tracks over 16,000 teens and adults with severe asthma to see if the drug tezepelumab raises the risk of serious heart problems like heart attack, stroke, or heart-related death. Researchers will compare those taking tezepelumab to those on standard asthma treatments. …

This study looks at whether a structured program can help more high-risk smokers get a first lung cancer screening with a CT scan. About 500 people aged 50 to 74 who smoke or recently quit will join. The goal is to see if a dedicated network makes screening easier and more effect…

This study looks at whether airway inflammation from asthma can cause brain inflammation and affect mood. Over six visits, 50 adults with mild asthma will complete questionnaires, computer tasks, allergy tests, breathing tests, blood draws, and brain scans. The goal is to underst…

This study looks at how asthma-related inflammation in the lungs might affect the brain and contribute to depression and anxiety. Researchers will compare brain scans, blood tests, and breathing tests between 100 adults with asthma and healthy volunteers. The goal is to understan…

This study looks at how simulated high altitude (2,500 m and 4,000 m) affects the right side of the heart in people with well-controlled asthma. Eighteen participants will breathe special gas mixtures to mimic altitude while resting and doing light exercise. The goal is to learn …

This study looks at whether treating obstructive sleep apnea (OSA) with a CPAP machine can improve asthma control in people with difficult-to-treat asthma. Eighty adults will be randomly assigned to receive CPAP, no OSA treatment, or serve as a reference group without OSA. The go…

This observational study is developing a computer model to identify different types of bronchiectasis in adults. Researchers will collect health data from 750 participants over time to see if they can predict disease patterns. No treatments or interventions are given; participant…

This observational study will follow 500 adults in Taiwan who are receiving biologic treatments (such as omalizumab, mepolizumab, or dupilumab) for severe asthma. Researchers aim to see how well these drugs work in everyday practice, what factors predict better control, and how o…

This study follows 1,000 people aged 12 and older in China who have severe eosinophilic asthma and are prescribed benralizumab. Researchers will track how well the drug controls asthma symptoms over time using questionnaires, and note reasons for stopping or switching treatment. …

This study is creating a new scoring system called BASE to measure how severe bronchiectasis is and predict the chance of a flare-up over the next year. Researchers will follow 750 adults with non-cystic fibrosis bronchiectasis for 12 months, collecting routine medical data. No n…

This study looks at 80 adults—40 with NTM lung disease (not on antibiotics) and 40 with bronchiectasis alone—to see if their health needs differ. Using questionnaires and simple physical tests, researchers will assess quality of life, nutrition, mood, and muscle strength. The goa…

This study looks at how having heart problems affects the severity of lung flare-ups and quality of life in people with bronchiectasis (a chronic lung condition). Researchers will compare 30 adults with bronchiectasis who also have heart conditions to those without heart issues. …

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study is looking for 530 adults with hay fever in South-Eastern Australia to help create a tool that predicts thunderstorm asthma. Participants will have allergy and lung function tests, then track their symptoms during spring for two years. The goal is to find warning signs…

This study uses advanced lung imaging to see how two asthma medications—albuterol alone and albuterol combined with budesonide—change airflow and blood flow in the lungs. About 40 adults with asthma will undergo scans before and after taking the medications. The goal is to better…

This study is building a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, severe asthma, and psoriasis. Researchers will collect blood samples and track disease activity over time using standard medical scores. The goa…

This study is a registry that collects health information from 714 Canadian adults with severe asthma over five years. Researchers will track symptoms, medication use, and lung function to better understand the disease and how patients respond to current treatments. No new drugs …

This study is a registry that will collect information from 5,000 people with severe asthma over time. The goal is to better understand the disease, how well patients follow their treatment plans, and how different biologic medications work in everyday life. Participants must be …

This study is observing 2,500 people with asthma to learn more about their symptoms, treatments, and quality of life in everyday settings. Participants will fill out surveys and may provide blood samples or lung function tests. The goal is to better understand how asthma affects …

This study aims to understand why people with asthma produce excess mucus. Researchers will collect airway cells from 24 volunteers (some with asthma, some healthy) using a thin tube passed into the lungs. By comparing the cells' genetic activity, they hope to pinpoint key molecu…

This study follows 6,000 children in Switzerland who have breathing issues like wheezing, coughing, or trouble breathing during exercise. Researchers collect information from doctor visits and surveys to better understand these problems and improve care. The goal is to learn more…

This study is a registry that will collect information from about 9,000 adults with uncontrolled asthma across 70 clinics in Russia. Researchers will look at patients' medical records and current health to describe their characteristics, such as age, smoking habits, and lung func…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study tracks 30 adults with asthma to see if changes in indoor and outdoor air pollution are linked to asthma attacks. Participants will have sensors placed in their homes to measure pollutants like fine particles and chemicals. The goal is to understand which pollutants are…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study will check how many workers in an industrial zone in Thailand have asthma or COPD. About 310 adults will answer a questionnaire and take a breathing test. The goal is to find out how common these lung problems are in this group, not to test a treatment.

This study aims to find out how many adults with severe asthma in Thailand achieve remission and what factors might help. Researchers will ask participants about their asthma symptoms, do breathing tests, and take a blood sample once. The study does not provide any treatment—it o…

This observational study will track 289 adults with mild-to-moderate asthma in Thailand to see how many achieve remission and what factors are linked to it. Participants fill out a symptom questionnaire, take a breathing test, and give a blood sample once. The study does not test…

This study examines how germs living on and in the body, along with environmental factors like pollution, may influence allergic diseases such as asthma and eczema in people living in Mali. Researchers will collect samples and health information from 288 participants, both with a…

This study is a global registry that collects health information from 500 adults with severe asthma. The goal is to track how patients respond to treatments and understand the disease better. The data will help researchers develop improved care and therapies for severe asthma.

This study looks at how body composition (like weight and fat distribution) relates to airway tone and reactivity. Researchers will use a device called an oscillometer to measure airway resistance in 100 people who are already scheduled for a methacholine challenge test. The goal…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study follows 1,200 adults with asthma (with or without nasal polyps) for up to 7 years to see how their condition changes over time. Researchers will track symptoms, treatments, and biomarkers in blood and breath. The goal is to better understand different types of asthma a…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study is enrolling 100 adults with stable bronchiectasis (a chronic lung condition) to see if certain blood markers and CT scan findings can predict who will have frequent flare-ups. Researchers will measure inflammation markers like CRP and cell ratios, along with detailed …

This study looks at physical fitness in children aged 7 to 18 who have bronchiectasis, a lung condition. Researchers will use fun, game-like tests to measure fitness, along with lung function and muscle strength. The goal is to better understand how the disease impacts children's…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study tests a soft, wearable stethoscope that can continuously listen to a child's breathing and detect wheezing, a sign of an asthma attack. Researchers at Emory University will enroll 25 children hospitalized for asthma to wear the device for up to 8 hours. The goal is to …

This study is looking for proteins and other markers in exhaled breath that could help doctors monitor lung inflammation and infections in people with asthma or cystic fibrosis. Researchers will collect breath samples from 450 participants (including healthy volunteers) and compa…

This study looks back at how biologic drugs are being used to treat severe asthma in Hong Kong. Researchers will review the medical records of 360 adults to see which biologics are prescribed, how well they control asthma, and any side effects. The goal is to understand current p…

This study looks at how genes are linked to different types and severities of asthma in Chinese patients. Researchers will collect genetic data from 2,000 people with asthma to find common gene variants. The goal is to better understand asthma in this population, which has been u…

This study looks at how tiny organisms in the airways, like bacteria and viruses, relate to different types of asthma in adults. Researchers will collect samples from 140 adults with asthma to see if certain microbial patterns are linked to asthma severity and control. The goal i…

This study follows 500 adults in Hong Kong with severe asthma who are on high-dose treatments (step 4 or 5 of GINA guidelines). Researchers will track how well their asthma is controlled and how often they have flare-ups over two years. The goal is to gather local data to help do…

This observational study is investigating how patients with chronic airway diseases like COPD and asthma perceive breathing difficulty. Researchers will assess about 950 participants (800 patients and 150 healthy volunteers) using questionnaires, lung function tests, blood sample…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers will test if a select group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy, hig…

This study looks at 1,000 children (ages 5-18) with dust mite allergies to see if customizing allergy shots based on their specific mite protein sensitivities leads to better symptom control. Participants get a detailed blood test to map their allergy profile and are followed for…

This study looks at whether tongue images and pulse wave data can help doctors better understand and monitor asthma in children aged 5 to 18. Researchers will collect these non-invasive measurements during routine clinic visits and compare them with standard lung function tests. …

This study explores whether machine learning can analyze breathing test results to predict chronic respiratory diseases like asthma and COPD. Researchers will compare a newer technique called oscillometry with standard spirometry in 50 adults. The goal is to see if this approach …

This study is testing two new types of lung MRI that use special gases (xenon and perfluoropropane) to create detailed images of lung function. Researchers will compare these scans in 30 people with cystic fibrosis, asthma, and healthy volunteers to see if they can spot lung prob…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an NTM infection. Researchers will collect sputum and airway samples from 1000 participants to compare the lung microbiome of those with and withou…

This study is gathering detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze clinical, biological, and lifestyle factors to identify distinct disease subtypes. …

This study looks at the bacteria (microbiomes) in the airways of infants under 2 years old with severe asthma. Researchers will collect blood, nasal swabs, and sputum samples to understand how these microbiomes relate to the disease. The goal is to find new ways to improve care a…

This observational study enrolls 500 children aged 6-17 who come to the emergency department with an acute asthma attack. Researchers will check if doctors follow the latest GINA 2025 guidelines for diagnosis, treatment, and follow-up. The goal is to see if standardizing care imp…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study explores whether people who seek help for both their allergies and their mental health (like anxiety or depression) have better control over their symptoms. Researchers will look at health records from 200,000 adults over several years. The goal is to understand if com…

This study looks at how indoor air and dust pollutants in classrooms impact children's allergies and lung function. Researchers will monitor 100 children, comparing those with allergies to those without, using questionnaires, allergy tests, and breathing tests. The goal is to ide…

This study aims to understand how the throat and esophagus normally prevent stomach contents from reaching the throat in people with GERD. Researchers will use a thin tube with sensors placed through the nose to measure pressure, acid, and liquid movement, along with a tiny camer…

This long-term study follows 1,000 people with eczema and related allergies, plus healthy volunteers, to see what factors help the disease go into remission. Researchers will collect medical and lifestyle data to find patterns and possible biomarkers. The goal is to better unders…

This study aims to find the genetic causes behind certain allergic and immune system disorders. Researchers will collect blood, saliva, and tissue samples from up to 10,000 people of all ages, along with some family members. No treatments are given; the goal is simply to learn mo…

This study follows 200 infants hospitalized with lower respiratory tract infections (like bronchiolitis) to see if lung ultrasound and special breathing tests can help doctors predict how sick a child will get and who might develop asthma later. Researchers will track symptoms, h…

This study looks at how the diaphragm, the main muscle used for breathing, works in people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. About 800 adults will take breat…

This study looks at blood and urine samples from 100 children aged 12-17 with asthma to find chemical markers that signal an asthma attack. Participants continue their usual asthma medications. The goal is to better understand how asthma changes in the body, which could lead to e…

This study uses cardiac MRI and other tests to examine heart and lung function in 510 COVID-19 survivors who had symptoms like shortness of breath or cough. The goal is to find out why some people have lasting cardiopulmonary problems after COVID-19. Participants will undergo ima…

This study tests whether computer-based decision support tools can help doctors reduce unnecessary antibiotic use in children with lower respiratory tract infections like pneumonia, bronchiolitis, and asthma flare-ups. Most of these infections are caused by viruses, not bacteria,…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study will enroll 900 children aged 5-17 with asthma to see if remote monitoring—using routine health data and a smartphone app—can predict asthma attacks. Researchers will track whether this system reduces the number of attacks compared to past averages. A subset of high-ri…

This study looks at two proteins, ezrin and Pip5k1α, in the airway muscles of people with and without asthma. Researchers will analyze lung tissue samples from 120 adults to see if these proteins are different in asthma patients. The goal is to better understand asthma and find n…

This early-stage study tests a new drug called RSS0343 in 48 healthy adults to see if it is safe and how the body handles it. Participants take the drug or a placebo by mouth for a short time. The goal is to check for side effects and measure drug levels in the blood. This study …

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study interviews 15 adults with severe asthma to understand their experiences after an 8-week breathing muscle training program. Researchers want to learn how the training affects physical activity, coping with symptoms, and self-management. The goal is to gather patient ins…

This observational study will use CT scans to measure mucus plugging in the airways of people with asthma, COPD, or chronic cough, and compare them to healthy volunteers. Researchers hope to understand how mucus changes over time and find biomarkers that could guide treatment. Th…

This study follows 150 adults with bronchiectasis for two years to understand how bacteria in the airways and gut influence disease progression. Researchers will also examine how macrolide antibiotics (like azithromycin) work to improve symptoms. Participants provide sputum, stoo…

This study looks at how fungi in the environment (like mold in homes) affect people with asthma, allergic bronchopulmonary aspergillosis (ABPA), and bronchiectasis. Researchers will collect dust and sputum samples from 125 adults aged 18–80 and follow them for 6 months. The goal …

This study looks at 60 adults aged 35-75 with allergic or eosinophilic asthma to see if their symptoms, breathing problems, and frailty levels differ. Researchers will measure lung function, breathlessness, fatigue, and quality of life. The goal is to help health professionals de…

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study is testing whether wearable sensors that track things like heart rate and breathing can detect changes during a chest infection in adults with cystic fibrosis or bronchiectasis. Researchers will monitor 50 patients who are starting intravenous antibiotics for a lung in…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study aims to better understand bronchiectasis, a chronic lung disease, in Chinese patients. Researchers will collect data from 1500 adults to identify different disease types and their underlying causes. The goal is to improve diagnosis and tailor treatments for each patien…

This study follows 1,850 bronchiectasis patients over three years, collecting sputum samples monthly to analyze how lung bacteria change over time. Researchers will sequence the DNA of bacteria like Pseudomonas aeruginosa to see how they evolve and become resistant to antibiotics…

This study looks at how mucus plugs block airways in people with severe asthma. Using special xenon MRI scans, researchers will measure how these plugs affect breathing and gas exchange. Five adults with severe asthma will be scanned before and after starting biologic therapy to …

This study is a registry that collects contact information from people of all ages who are interested in joining future clinical trials for allergies or asthma. No treatments or tests are given—it simply helps researchers find volunteers for upcoming studies. Anyone from 0 to 100…

This study aims to find the genes that make some people develop severe COPD at a young age, even if they smoke. Researchers will collect DNA and health information from 2,000 participants with early-onset COPD. The goal is to understand why some people are more prone to this lung…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study aims to understand and improve how patients with COPD and asthma use their inhalers. Researchers will assess patients' inhaler technique and provide education, while also evaluating healthcare professionals' knowledge. The goal is to boost adherence to treatment and re…

This study follows 250 adults with asthma over about 5 years to see how the disease varies from person to person and changes over time. Researchers will track lung function, symptoms, triggers, and flare-ups through annual clinic visits and home assessments. The goal is to better…

This study looks at how nutrition impacts the progression of bronchiectasis, a chronic lung disease. Researchers will measure things like arm circumference, grip strength, and body mass index in 300 adults. They will track how often participants have flare-ups and how their lung …

This study looks at how the lungs of people with asthma react when exposed to common allergens like cat hair or dust mites. Researchers will use a bronchoscope to deliver tiny amounts of allergen into the lung and then collect fluid to study which immune cells show up. The goal i…

This study is creating a registry of people with emphysema to collect DNA, lung function tests, and medical information. Researchers hope to use this data to better understand the disease and develop new therapies. The registry will also help identify volunteers for future resear…

This study looks at how changing sleep time affects the immune system and breathing in urban children with asthma. Researchers will ask some children to go to bed 90 minutes later for a week, while others keep their usual bedtime. They aim to understand if short sleep worsens ast…

This study follows 1,000 adults who took part in earlier EGEA surveys, comparing those with and without asthma. Researchers will measure heart disease risk markers like the Framingham score and blood biomarkers. The goal is to understand if asthma itself increases cardiovascular …

This study tests a new care pathway for children having mild-to-moderate asthma attacks. The goal is to make sure every child gets the same high-quality treatment, like using a spacer with their inhaler. Researchers will track how well doctors follow the new plan and look for way…

This study tests two strategies to help doctors prescribe SMART therapy—a single inhaler for daily control and quick relief—for children with moderate to severe asthma. Researchers will use electronic reminders and education, plus a community health worker and nurse care manager,…

This study tests whether giving doctors extra training and electronic reminders helps them prescribe a modern asthma treatment called SMART for children with moderate to severe asthma. The study involves 18 children ages 5 to 18 at primary care clinics. Researchers will compare h…

This study looks at whether a breathing test called impulse oscillometry (IOS) can help doctors monitor asthma better than standard tests. Fifty adults with asthma will take IOS and other lung function tests, plus fill out questionnaires, at the start and again 3-6 months after a…

This study is for adults with asthma whose symptoms don't improve with standard inhalers. Researchers will use advanced MRI and CT scans to see if structural problems in the airways—like narrowing or mucus plugs—prevent inhaled medications from reaching the lungs. Participants wi…

This study surveys 384 adults in Türkiye who have completed a pulmonary rehabilitation program for lung conditions like COPD or asthma. Researchers want to learn how satisfied patients are and how the rehab team's structure affects their experience. No new treatment is being test…