Bronchial disorder

This study tests whether a triple-combination inhaler (containing an anti-inflammatory, a long-acting bronchodilator, and another bronchodilator) works better than a standard double-combination inhaler for people whose asthma is not well controlled. About 644 adults with asthma w…

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This phase 3 trial tests whether a daily tablet called florensocatib can reduce the number of lung flare-ups in people with bronchiectasis, a chronic lung condition. About 904 participants aged 12 to 85 will be randomly assigned to receive either the drug or a placebo for up to 7…

This study tests whether a single injection of dexamethasone works as well as a 5-day course of prednisone pills to prevent asthma patients from returning to the emergency room. About 182 adults with asthma will be randomly assigned to get either the shot or the pills. Researcher…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This study tests whether a structured remote clinic using video calls can reduce the number of severe asthma attacks in adults who have just been discharged from the hospital after an asthma flare-up. 220 participants will be randomly assigned to either two remote pulmonology vis…

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This study observes 210 patients in South Korea who are prescribed Tezepelumab for severe asthma or chronic sinusitis with nasal polyps. Researchers will track side effects and how well the drug controls symptoms in everyday use. The goal is to confirm the drug's safety and effec…

This study tests whether taking a low dose of the antibiotic azithromycin every day for a year can reduce the number of serious lung infection flare-ups in adults with non-CF bronchiectasis. About 500 participants will receive either azithromycin or a placebo pill, added to their…

This study tests whether arranging a telehealth appointment with an asthma specialist before patients leave the emergency room increases follow-up care. Forty adults who come to the ER for an asthma attack will either get a scheduled telehealth visit or usual care. The goal is to…

This study tests whether text-message reminders and coaching can help 389 teens (ages 12-18) with moderate to severe asthma take their daily inhaled steroids as prescribed. Participants will be split into three groups: one gets a basic asthma app, another adds personalized text r…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests whether a monthly injection called Tezepelumab can help adults with severe asthma avoid repeated emergency room visits and asthma attacks. One hundred participants will receive either the drug or a placebo for 90 days, followed by an open-label extension. The goa…

This study tests a family-empowered pulmonary rehabilitation program for school-age children (6-12 years) with asthma. The program includes education, skills training, and home-based guidance. Researchers will compare it to standard care in 92 children to see if it improves asthm…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether a new inhaler with three medicines (CHF 5993) works better than a standard two-medicine inhaler (CHF 1535) for people whose asthma is not well controlled. About 554 adults in China will use one of the two inhalers for 24 weeks. The main goal is to see if …

This study tests a new drug called frevecitinib (KN-002) in 512 adults with severe asthma that is not well controlled by their current treatments. Participants will take one of three doses of the drug or a placebo daily for 12 weeks. The main goal is to see if the drug improves l…

This early-stage study tests a new drug called cizutamig in about 20 adults with IgE-mediated allergies, including food allergies. The main goal is to see if the drug can safely lower IgE levels, which are antibodies that trigger allergic reactions. Researchers will also monitor …

This large study aims to create a digital screening and management system for adults with asthma and allergies. Nearly 10,000 participants will use a smartphone platform to track symptoms and receive guidance on three non-drug strategies: avoiding allergens (like dust mites), inc…

This study gives ongoing access to benralizumab (Fasenra) for people with asthma, eosinophilic granulomatosis with polyangiitis (EGPA), or hypereosinophilic syndrome (HES) who completed a prior benralizumab trial and still benefit from the drug. About 230 participants will receiv…

This study tests a program where children with asthma take their daily medicine at school, supervised by staff. The goal is to see if this helps more children take their medicine correctly and reduces asthma attacks. The trial will include 300 children in Rochester, New York, and…

This study will test whether a 12-week vegan diet can lower inflammation in adults with mild to moderate asthma compared to a balanced omnivorous diet. Researchers will measure immune markers and asthma control in 280 participants aged 18-30. The trial is not yet recruiting.

This study tests a digital health assistant called 'Alex' to help children and teens aged 10 to 19 with asthma. Over six months, the app tracks lung function, symptoms, and medication use, and later gives personalized advice. The goal is to see if it improves asthma control and m…

This study tests two ways to use asthma inhalers to prevent serious attacks. One strategy (MART) uses a combination inhaler for daily control and quick relief. The other (PARTICS) adds a separate steroid inhaler whenever a rescue inhaler is used. About 4,100 adults with moderate-…

This early-phase trial is testing whether inhaling tiny particles from stem cells (called small extracellular vesicles) can safely help people with both allergic rhinitis and asthma. About 18 adults will receive either the active treatment or a placebo via nebulizer daily for two…

This study tests whether a slow-release form of the hormone DHEA can improve asthma control in adults aged 18 to 50. Standard asthma steroids can lower the body's own DHEA, so supplementing it might help. The trial will compare DHEA capsules to a placebo in 30 participants, measu…

This Phase 2 study tests a new drug called AK139 in 160 people with moderate to severe asthma. Participants receive either AK139 or a placebo by injection under the skin. The trial measures changes in lung function and asthma control over time, while also checking for side effect…

This study tests whether installing a radon mitigation system in homes can improve asthma symptoms. Researchers will compare a real system to a sham (inactive) system in 180 adults with uncontrolled asthma. The goal is to see if lowering radon levels leads to fewer days with asth…

This Phase 2 trial tests an injectable drug called RC1416 in 195 adults with moderate to severe asthma that is not well controlled. Participants will receive either the drug or a placebo by injection. The study will measure changes in lung function and track asthma attacks over t…

This study looks at adults with asthma that is not well controlled by their current medium-dose inhaler. Researchers want to see if switching to a higher dose or a different type of inhaler can improve the function of the small airways in the lungs. About 130 participants will be…

This study tests a new once-daily inhaler called QVM149, which combines three medicines (indacaterol, glycopyrronium, and mometasone furoate) to control asthma. It will enroll 304 teenagers aged 12 to 17 and compare the new inhaler to a standard twice-daily treatment (salmeterol/…

This study tests whether children aged 6–12 with chronic lung infections (like bronchiectasis) can improve their exercise ability and lung clearance using online physiotherapy sessions. Over 12 weeks, 32 children will either receive remote guided breathing exercises and workouts …

This study tests whether giving children a single inhaler for both daily control and quick symptom relief at school can reduce asthma attacks and emergency visits. About 330 children aged 6–12 with moderate-to-severe asthma will take part across Rochester City schools. School nur…

This study tests whether adding a traditional Chinese medicine powder called Modified Shenling Baizhu Powder to standard asthma inhalers can improve symptom control in people with allergic asthma. Researchers will enroll 400 adults aged 18 to 80 who have persistent asthma and a s…

This Phase 3 trial tests a new inhaler called N0783 against a standard asthma inhaler (Alenia) in 174 adults with moderate asthma. The goal is to see if the new drug works just as well at improving lung function and controlling symptoms. Participants will be randomly assigned to …

This study tests whether adding black seed oil (Nigella sativa) to standard asthma medication can improve asthma control and lung function in children aged 6–18 with moderate persistent asthma. Ninety children will receive either a low or high dose of black seed oil capsules or a…

This study tests whether a new drug called QL2302 works as well as the approved drug Tezspire for people with severe asthma that is not controlled by current treatments. About 636 adults aged 18-80 will receive injections every 4 weeks for 48 weeks, then be monitored for another …

This phase 3 trial tests whether taking the antibiotic moxifloxacin for 7 days every 8 weeks (for a year) can reduce lung infection flare-ups in people with non-cystic fibrosis bronchiectasis. 140 adults who have had at least two flare-ups in the past year will be randomly assign…

This Phase 2 trial tests AD17002, a nasal spray that aims to calm the immune system in people with moderate to severe eosinophilic asthma that is not well controlled by current treatments. About 126 adults will receive either the spray or a placebo for 3 months. Researchers will …

This study tests a new drug, linvemastat, for adults with moderate-to-severe asthma that is not fully controlled by standard inhalers. About 135 participants will receive either one of two doses of linvemastat or a placebo, while continuing their usual medications. Over 16 weeks,…

This study compares a joint consultation with both a lung doctor (pulmonologist) and an ear-nose-throat (ENT) specialist against separate visits for people with asthma and chronic sinusitis with nasal polyps. The main goal is to see if the joint approach reduces the need for oral…

This phase 3 trial tests QL2107, a biosimilar (copy) of the cancer drug Keytruda, in 122 adults with non-small cell lung cancer that has been surgically removed. The goal is to see if the body processes QL2107 the same way as Keytruda when given as an extra treatment after surger…

This study evaluates a portable device that measures lung function using oscillometry—a technique that sends gentle sound waves into the lungs—to diagnose chronic respiratory diseases like COPD, asthma, and bronchiectasis. Researchers will enroll about 4,000 adults across 50 cent…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study will collect cough sounds, breath sounds, and symptom questionnaires from 1,400 children with respiratory symptoms like cough or fever. Researchers will use this data to build a computer model that can help diagnose conditions like asthma and pneumonia. The goal is to …

This study is testing a new, easy way to diagnose asthma and COPD using a handheld device that measures carbon dioxide in a person's breath. Instead of the current uncomfortable and time-consuming lung tests, participants simply breathe normally into the device for 75 seconds. Th…

This study will check how well two simple questionnaires (GINA-P and ACT-P) measure asthma control in adults. About 144 people with asthma will answer questions about their symptoms and take a breathing test. The goal is to see if these questionnaires can reliably tell if someone…

This study aims to find the best concentration of Blomia tropicalis (a type of dust mite) extract for allergy skin testing. About 30 adults with known dust mite allergies will receive small pricks with different extract strengths to see which causes a reaction similar to a standa…

This study tests a computer program that scans electronic medical records to help family doctors find asthma in children aged 2 to 5. The goal is to catch the disease earlier, which could reduce serious breathing problems and deaths. About 300 children from four clinics in France…

This study will follow over 200,000 infants in France to see if early immunization with nirsevimab, an antibody against RSV, reduces wheezing episodes in preschool years. Researchers will compare hospitalization rates for wheezing between immunized and non-immunized children. The…

This study tests whether an extra virgin olive oil and water mouthwash can remove more leftover asthma medication from the mouth than plain water. The medication residue can cause problems like thrush or sleep apnea. Twenty healthy adults and adults with asthma will rinse with di…

This study checks if a new propellant (HFA-152a) in asthma inhalers is as safe as the current one (HFA-134a). About 110 adults with asthma will use both types of inhalers and be monitored for side effects. The goal is to make sure the new propellant is safe for everyday use.

This study tests whether adding exercise sessions and asthma education to usual care helps children aged 10-17 manage their asthma better. 60 participants will be randomly placed into one of three groups: usual care only, education only, or exercise plus education. The goal is to…

This pilot study tests a 12-month structured nursing program called RESPiraIA-Asma for adults with poorly controlled, non-severe asthma. The program combines education, inhaler training, home peak-flow monitoring, and personalized care plans, offered in-person, digitally, or mixe…

This study tests whether wearing a special LED vest for 20 minutes twice a week can improve lung function and exercise ability in children aged 6 to 17 with mild to moderate asthma. The vest uses light to reduce inflammation without heat. Half the children will get the active ves…

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

This study tests whether acupuncture can help people with mild-to-moderate chronic asthma breathe better and feel less anxious or depressed. 180 adults will be randomly assigned to real acupuncture, fake acupuncture, or usual care. The main goal is to see if real acupuncture impr…

This study tests whether a supervised exercise and education program (pulmonary rehabilitation) can help people with long-term lung diseases like COPD, asthma, and post-TB lung damage in Nigeria, South Africa, and Cameroon. Researchers will enroll 90 patients to see if the progra…

This study looks at whether replacing gas stoves with portable electric hot plates and toaster ovens can improve indoor air quality and asthma control. About 20 adults with poorly controlled asthma who cook with gas at least three times a week will participate. Researchers will m…

This pilot study tests whether anakinra, a drug that reduces inflammation, can help people with moderate asthma attacks. 60 adults at high risk for asthma attacks will either receive anakinra or a placebo at home when they feel an attack starting. The study will check if this app…

This study tests whether giving children aged 5-17 with severe asthma attacks early breathing support (called BPAP) in the emergency room is practical and safe. About 36 children will either get standard asthma care alone or standard care plus BPAP. The goal is to see if this app…

This study tests whether a 12-week telerehabilitation program—supervised resistance and endurance training done at home—can improve exercise capacity and quality of life in 80 adults with bronchiectasis. Participants are randomly assigned to either the training program or usual c…

This study tests whether a herbal medicine called Lifei Qingchang Granules can improve breathing and quality of life in people with stable bronchiectasis, a chronic lung condition. About 150 adults aged 18-75 who have had at least one flare-up in the past year will take either th…

This study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …

This Phase 2 trial tests whether inhaling L-menthol before exercise can reduce breathlessness and improve exercise capacity in 20 adults with asthma. Participants will receive L-menthol or a strawberry-scented placebo in random order, then cycle to measure their breathing and dis…

This study looks at whether CPAP, a machine that pushes air through a mask at night, can help people with large airway collapse (LAC). LAC causes shortness of breath, cough, and wheeze, and is often mistaken for asthma. The study will test if a larger trial is possible by checkin…

This study tests a program called CALM that helps Black adults with asthma cope with stress. Researchers want to see if the program is practical and well-liked by participants. About 50 adults who have persistent, uncontrolled asthma and moderate-to-high stress will take part.

This study tests whether it is safe to repeat a procedure called metered cryospray in people with COPD and chronic bronchitis who have already had it once. Only 10 participants will be enrolled. The main goal is to see if the treatment can be fully delivered and to track any seri…

This study compares two common steroids (dexamethasone and methylprednisolone) in children aged 3-17 hospitalized for severe asthma. The goal is to see which treatment reduces the need for more steroids after leaving the hospital and improves quality of life. The trial will help …

This pilot study will test the Simeox 200, a device designed to help clear mucus from the lungs, in 35 adults with bronchiectasis who produce a lot of phlegm. Participants will use the device twice daily for two weeks, and researchers will measure how much mucus is cleared, along…

This early-stage study tests a new drug called BBT002 in healthy volunteers and people with chronic sinusitis, nasal polyps, and asthma. The main goal is to check the drug's safety and how the body processes it. Researchers will also look for signs that the drug helps control sym…

This study tests a new digital program designed to help people with moderate to severe asthma manage breathlessness and increase physical activity. Researchers will compare the program to usual care in 300 adults. The goal is to see if the program improves quality of life and ast…

This study tests whether a program called Body Awareness Therapy can help adults with asthma improve their physical function, breathing, and emotional well-being. 67 adults with stable asthma will be randomly assigned to either the therapy group or standard care. The therapy incl…

This study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.

This study compares two types of inhalers—pressurized metered dose inhalers (pMDI) and dry powder inhalers (DPI)—to see which delivers asthma medication more effectively. Researchers will enroll 210 patients with uncontrolled asthma and measure changes in symptom control after 8 …

This early-stage trial tests a single oral dose of ADO-5030 in 36 adults with mild-to-moderate asthma. Researchers will check safety and how the drug affects breathing during a controlled airway challenge. The goal is to gather initial data, not to prove the drug works yet.

This study looks at whether adding expiratory muscle training (using a handheld device) to standard pulmonary rehabilitation can improve lung function, breathing strength, and exercise capacity in adults with bronchiectasis. Forty participants will be randomly assigned to rehab a…

This study will compare two methods of giving N-acetylcysteine—a drug that thins mucus—to 70 adults hospitalized with bronchiectasis. Half will receive the drug through a nebulizer (inhaled), and half through an IV. Researchers will measure how well each method reduces sputum thi…

This study tests whether adding a Chinese herbal formula called Liqin Zhike to standard asthma inhalers (ICS/LABA) can reduce the chance of cough returning in people with cough variant asthma. About 236 adults aged 18 to 70 who are newly diagnosed will take either the inhaler alo…

This Phase 3 trial tests an experimental drug called AG2001 in 300 adults with acute bronchitis. Participants take the drug three times daily for 7 days. The goal is to see if AG2001 reduces cough and mucus better than two other active drugs by day 4. The study is not yet recruit…

This study uses a quick, non-invasive breath test (FeNO) to measure airway inflammation in adults with asthma who are treated in primary care or community specialty clinics. The goal is to see how many patients have type 2 inflammation, which often goes undetected. Researchers ho…

This study follows people with chronic lung diseases like bronchiectasis, cystic fibrosis, and COPD to understand how bacteria become resistant to antibiotics. Researchers will collect samples and health data over time to map resistance patterns and genetic causes. The goal is to…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study looks at how to get all pediatric clinics and hospitals in the Basque Health Service to use a proven care plan for children with asthma attacks. About 4,680 children will be involved. The goal is to see which strategies work best to make sure every child gets the right…

This study compares a new visual bronchial blocker (with a tiny camera) to the standard blind method for placing a breathing tube during lung surgery. About 652 adults having lung, esophagus, or chest surgery will take part. The goal is to see if the camera-guided tool improves f…

This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to peopl…

This study aims to find out how often people with FLNA gene mutations develop emphysema, a type of lung disease. Researchers will use chest CT scans, blood tests, and lung function tests in 70 participants. The goal is to confirm if FLNA changes are a cause of unexplained emphyse…

This study will test 60 adults with bronchiectasis (a chronic lung condition) to see if they have an undiagnosed genetic disorder called primary ciliary dyskinesia (PCD). Researchers will measure nitric oxide in the nose and examine tiny hair-like cells from a nasal swab under a …

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study aims to find out how often rhinovirus (the virus behind many common colds) causes serious breathing problems that require hospital care in children. Researchers will follow 120 young children at home for 3 years and study 450 hospitalized infants and children, plus 100…

This study looks at whether eating all your meals between 8 AM and 4 PM (early time-restricted eating) can improve health and quality of life. Researchers will compare results in 36 adults—some with mild, well-controlled asthma and some without asthma. Participants eat their norm…

This study will look at how well asthma is controlled in 42,000 children in China and what types of airway inflammation they have. Researchers will use tests to measure asthma control and inflammation patterns. The goal is to find ways to improve treatment, educate families, and …

This study will ask 460 teenagers with asthma in China to fill out questionnaires about their asthma control, anxiety, depression, and self-care skills. The goal is to understand how mental health and disease management are connected in this age group. No new treatments or medica…

This study follows 270 preterm babies (born before 32 weeks) from birth to age 3. Researchers will regularly swab their noses to analyze the bacteria and other microbes living there. The goal is to see if the nose microbiome can predict which babies will develop bronchopulmonary …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study will analyze data from 500 adults to see if depression and asthma are connected, and if one might cause the other. Researchers will use medical records and genetic information to identify factors like age, smoking, or weight that could influence the link. No new treatm…

This study tests a mobile app called ALRITE that helps health workers in Uganda diagnose and manage breathing illnesses in young children. The app guides them through patient information and gives treatment recommendations. Researchers will see if using the app improves how often…

This study will enroll 120 adults with asthma or COPD to see how changes in lung function tests (spirometry and impulse oscillometry) relate to how much their breathing improves after using a bronchodilator. Participants will take a standard reversibility test and report their sy…

This study will test whether a brief educational session led by a nurse can help children aged 6-17 with asthma better manage their condition and use their inhaler correctly. The session covers understanding treatment, distinguishing between maintenance and rescue medications, an…

This study will follow 100 adults hospitalized for a sudden worsening of bronchiectasis. Researchers will track how conditions like COPD, diabetes, and heart disease, along with disease severity, affect the need for intensive care, length of hospital stay, and risk of death. The …

This study looks at 300 adults with bronchiectasis, a chronic lung condition, to understand why many also experience anxiety and depression. Researchers will collect blood, sputum, and stool samples to analyze metabolic pathways and identify biomarkers. The goal is to find clues …

This study uses artificial intelligence to understand how air pollution and climate change impact respiratory diseases like allergic rhinitis and asthma. Researchers will gather health data from about 1,900 patients across Europe and analyze it with AI tools to find better ways t…

This study tests whether watching a medical TV drama can improve asthma knowledge in people aged 18–35 without medical backgrounds. About 48 participants from different countries will be randomly assigned to watch the drama or not. Researchers will measure changes in asthma-relat…

This study compares two oral formulations of pranlukast, a drug used for asthma and allergic rhinitis, to see if they are equivalent. Sixty healthy adults will receive a single dose of each version in random order under fasting conditions. The main goal is to measure drug levels …

This observational study will analyze samples from 160 children with asthma, protracted bacterial bronchitis, or chronic cough to find biomarkers that predict disease progression and treatment response. Participants will undergo a bronchoscopy to collect lung fluid and tissue sam…

This study looks at how other health problems (comorbidities) and certain substances in the blood (biomarkers and microRNAs) affect asthma severity and treatment response in children aged 6 to 12. Researchers will track 82 children for one year to see which kids improve their lun…

This study looks at whether biologic therapy can reverse long-term lung damage in adults with severe asthma. Researchers will follow 150 patients and 50 healthy volunteers for two years, using advanced imaging and lung function tests. The goal is to see if treatment leads to 'cli…