Bronchial disorder

This study tests an experimental nasal vaccine made from a harmless virus (Sendai virus) that is similar to the one causing croup. The goal is to see if it is safe and helps children ages 1 to 5 build protection against croup. About 54 children will receive the vaccine as nose dr…

This Phase 3 trial tests whether a daily inhaler combining fluticasone (an anti-inflammatory steroid) and albuterol (a quick-relief bronchodilator) can prevent severe asthma attacks better than albuterol alone. About 2,772 adults with asthma who have had at least one severe attac…

This study tests a new injectable drug called lunsekimig in adults with high-risk asthma who cannot currently use other biologic treatments. The goal is to see if it can reduce asthma attacks and improve breathing over about a year. Around 1,147 participants will receive either t…

This study tests whether benralizumab can improve lung structure and function in people with severe eosinophilic asthma who still have symptoms despite standard treatments. About 75 adults aged 18-70 will receive either the drug or a placebo for 48 weeks, followed by a 4-week che…

This study looks at how safe and effective Fasenra (benralizumab) is for children aged 6 to 14 with severe asthma that isn't controlled by other treatments. Researchers will track side effects and measure lung function and asthma control in 40 children over time. The goal is to s…

This study tracks 416 people with severe asthma that isn't controlled by standard treatments. All participants receive Tezspire injections and are monitored for side effects, including serious allergic reactions, infections, and heart problems. The goal is to see how safe and eff…

This Phase 2 trial tests whether adding rademikibart (a shot) to standard care can help adults and teens with asthma and type 2 inflammation avoid hospital visits or needing more steroids during an attack. About 160 participants will receive either the drug or a placebo. The main…

This Phase 2 trial tests whether semaglutide (Wegovy), a drug approved for diabetes and weight loss, can improve asthma control in 100 adults with obesity and persistent asthma despite using inhaled steroids. Participants receive weekly injections of semaglutide or a placebo for …

This study looks at whether a dedicated asthma flare-up clinic can improve how adults manage their asthma after a severe attack. About 230 participants will either get structured in-person follow-up visits or phone check-ins. Researchers will compare rates of future asthma attack…

This study looks at the long-term safety and effectiveness of a drug called lunsekimig for adults with asthma. Participants have already completed a previous study with the same drug. They will receive lunsekimig injections for up to 144 weeks. The goal is to see if the drug rema…

This phase 2 trial tests a combination of two drugs—ceralasertib (a pill) and durvalumab (an infusion)—in 39 adults with advanced or metastatic non-small cell lung cancer that has worsened after standard treatments like immunotherapy and chemotherapy. The main goal is to see if t…

This study tests whether the drug tezepelumab can help people with severe asthma reduce their daily maintenance inhaler dose without losing control of their asthma. About 326 adolescents and adults will receive tezepelumab injections and then try to step down their usual inhaler …

This study follows 155 adults with severe asthma who are starting tezepelumab, a new biologic drug. Researchers will track symptom control, quality of life, and lung function over two years in real-life clinics across Greece. The goal is to see how well the drug works outside of …

This study tests a new drug called verekitug in 666 people with moderate-to-severe COPD, a long-term lung disease that makes breathing hard. The goal is to see if it can reduce serious flare-ups and improve lung function compared to a placebo. Participants must be current or form…

This study tests a daily tablet called BI 1291583 (Verducatib) in 268 adults with bronchiectasis, a long-term lung condition. Participants who were in earlier trials continue or switch to the drug for up to one year. The main goal is to check safety and see if the drug reduces lu…

This study tests a new medicine called SHR-1905 for people with severe asthma that is not well controlled by current treatments. About 260 adults will receive either the drug or a placebo to see if it reduces asthma attacks and improves breathing and quality of life. The goal is …

This study tests a 24-week lifestyle physical activity program designed for Black women with asthma. Participants are randomly assigned to either the activity program (group sessions, activity tracking, and text support) or an asthma education control group. The goal is to see if…

This study tests two versions of the asthma inhaler Symbicort (budesonide/formoterol) in children aged 4 to 12 with asthma. The goal is to see how much of the drug gets into the blood with each version and whether they are safe. Fifteen children will take single doses of both the…

This study tests whether adding the injectable drug dupilumab (Dupixent) to a medium-dose inhaler works better than simply increasing the inhaler dose for people whose asthma is still not under control. About 120 adults with uncontrolled asthma will be randomly assigned to one of…

This study tests a new medicine called GSK5784283 for adults with asthma that is not well controlled by their current treatments. The medicine blocks a protein called TSLP that can cause inflammation in the lungs. The trial will involve about 300 people and aims to find the best …

This study tests whether a dedicated asthma navigator—a respiratory therapist who provides education, scheduling help, and phone support—can reduce repeat hospital visits for children aged 5–16 admitted to the PICU for asthma. The goal is to improve health equity by addressing ba…

This study looks at the long-term safety and effectiveness of a drug called amlitelimab for adults with moderate-to-severe asthma. Participants have already completed a previous amlitelimab study. They will receive injections of amlitelimab or a placebo for up to 144 weeks. The g…

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who cannot have surgery or radiation. Researchers…

This phase 2 trial tests two drugs, durvalumab and oleclumab, given together after standard chemoradiation in 30 people with stage III lung cancer that cannot be removed by surgery. The goal is to see if the combination can delay cancer progression. Participants must have stable …

This study tests a program called TEAM-UP for Teens that uses school-based telemedicine visits and video check-ins to help teenagers with hard-to-control asthma. The goal is to reduce asthma symptoms and emergency visits. About 333 teens aged 12-17 from low-income urban areas wil…

This study is for adults with severe asthma who finished the earlier VALIANT trial. It tests the long-term safety and effectiveness of verekitug, a drug given as a shot. About 396 people are taking part. The main goal is to see if verekitug is safe over time and if it can reduce …

This early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, a…

This study follows 125 people aged 12 and older with severe asthma who are starting tezepelumab in Russia. Over 52 weeks, researchers will track how well their symptoms are controlled using a standard questionnaire. The goal is to see how the drug works outside of clinical trials…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This study aimed to see if a generic version of the fluticasone furoate/vilanterol inhaler (Sandoz) works as well as the brand-name Breo Ellipta in adults with asthma. Participants would have stopped their usual asthma meds and used only the study inhaler or a placebo for 4 weeks…

This study tests a smartphone app designed to make asthma easier to manage for 370 teenagers and young adults. The app is a digital version of an asthma action plan, helping users track symptoms and follow treatment guidelines. The goal is to see if using the app improves asthma …

This early study tests whether giving the drug Lutathera directly into the liver artery is safe and practical for people with neuroendocrine tumors that have spread mainly to the liver. Ten participants will receive two doses into the liver artery followed by two standard IV dose…

This Phase III trial tests whether adding immunotherapy to standard chemotherapy after lung cancer surgery can delay or prevent the cancer from coming back. It enrolls 210 patients with stage IB-IIIA non-small cell lung cancer that was completely removed. Participants are randoml…

This study tests an experimental drug, solrikitug, in 145 adults with asthma who already use daily inhalers. The goal is to see if the drug can safely lower certain immune cells (eosinophils) in the blood and improve asthma control compared to a placebo. It is a Phase 2 trial, me…

This study looks at how well a virtual program called Coach McLungs works for children with asthma. The program provides education and helps doctors and families make decisions together. Researchers will track whether kids have fewer asthma attacks and need fewer emergency visits…

This pilot study is testing a wearable device called AeviceMD that lets children with asthma and their caregivers monitor breathing at home. The device sends information to doctors, who can adjust treatment without an office visit. The goal is to see if this helps kids gain bette…

This study tests whether dupilumab, an injectable biologic, can slow the decline of lung function in adults with uncontrolled moderate to severe asthma. Over 1,300 participants will receive either dupilumab or a placebo for three years, alongside their usual asthma medications. T…

This study tests an oral drug called selpercatinib in people with advanced solid tumors that have RET gene alterations, including certain lung, thyroid, and colon cancers. The goal is to find the best dose and see if the drug can shrink tumors. About 857 participants are enrolled…

This study tests a new medicine, WIN378, for adults with moderate or severe asthma. WIN378 blocks a protein that causes lung inflammation, which may improve asthma control. About 136 participants will receive either WIN378 or a placebo to check safety, how the drug works in the b…

This study tests whether switching from a standard rescue inhaler (albuterol alone) to one that also contains an anti-inflammatory steroid (budesonide) can reduce severe asthma attacks. About 1,500 adults with asthma who have had at least one severe attack in the past year will u…

Asthma affects 1 in 11 children in the UK, and many don't use their inhalers correctly, leading to poor symptom control. This study tests a Smart Spacer device that monitors when and how well children use their inhalers. Researchers will give some children tailored education base…

This study tests whether a triple-combination inhaler (FF/UMEC/VI) works better than standard dual therapy (ICS/LABA) for adults whose asthma is not well controlled. About 1,366 participants will use either the triple inhaler or their usual treatment for 24 weeks. The main goal i…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study looks at whether a type of antibiotic (macrolide) can help children during asthma attacks, even when there is no clear bacterial infection. Researchers want to see if it shortens the attack and reduces the need for steroids. The study includes 70 children from a larger…

This early-stage trial tests a new inhaled nitric oxide treatment (RESP30X) in 60 adults with non-cystic fibrosis bronchiectasis who have stubborn lung infections like Pseudomonas. The main goals are to check safety and how well the body tolerates the mist, while also seeing if i…

This study looks at whether people aged 12 and older with a certain gene variant (IL-4RαR576) respond better to the asthma drug dupilumab. 150 participants will receive either dupilumab or a placebo for 48 weeks. The main goal is to see if the drug reduces asthma attacks more in …

This study tests whether a new propellant (HFO) for the budesonide/albuterol inhaler works as well as the current one (HFA) in adults with asthma. Over 400 participants will use three different inhalers over 12 weeks to compare lung function. The goal is to see if the new propell…

This 5-year study is looking at how well a year-round allergy treatment (MATA trees or MATA grass) works for children and adults with pollen allergies, including hay fever and mild asthma. Researchers want to see if the treatment is as effective in kids as it is in adults. About …

This study tests a new antibody drug (called 610) for adults with severe asthma that is not well controlled by standard inhalers. About 225 participants will receive either the drug or a placebo to see if it improves lung function and reduces asthma attacks over 52 weeks. The dru…

This study tests whether adding dupilumab (Dupixent) to standard asthma care can prevent asthma attacks in 240 urban children and teens aged 6–17 with severe, allergy-driven asthma. Participants receive either dupilumab or a placebo for 12 months. The main goal is to see if the d…

This pilot study tests whether taking a daily probiotic supplement for 12 weeks can improve insulin resistance and asthma control in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and asthma symptoms. Only 7 people are enroll…

This pilot study tests a community-academic partnership to help children with asthma in New Haven. It offers home visits from trained community health workers (Promotoras) and an online tool for doctors to guide asthma care. The goal is to see if this approach is feasible and can…

This study tests an oral drug called selpercatinib (LOXO-292) in children with advanced solid or brain tumors that have a specific RET gene change. The trial has two parts: first finding a safe dose, then measuring how many children's tumors shrink. About 36 children whose cancer…

This program provides taletrectinib, a targeted cancer pill, to adults with advanced or metastatic ROS1-positive non-small cell lung cancer who cannot join a clinical trial or use approved treatments. Patients must have a ROS1 gene fusion and adequate organ function. The goal is …

This study aimed to see if a new lower-dose asthma inhaler (formoterol 6 mcg/fluticasone 125 mcg) works as well as an existing one (formoterol 6 mcg/budesonide 200 mcg) for people aged 12 and older with moderate asthma. The trial was withdrawn before any participants were enrolle…

This study tests a web-based program called CAMP Air to help urban teens, mostly Black and Hispanic, better control their asthma. The program teaches steps to prevent symptoms and manage the condition. Researchers will check if it reduces asthma attacks and urgent care visits.

This early-stage study is testing an experimental drug called GB-0895 in 156 adults with mild-to-moderate asthma or COPD. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as an injection under the skin.…

This study provides early access to brensocatib, an experimental tablet, for people with non-cystic fibrosis bronchiectasis who finished the ASPEN trial. Participants must have already taken brensocatib without serious side effects. The goal is to offer continued treatment while …

This study looks at whether being overweight makes children with asthma more sensitive to air pollution. About 200 children from Baltimore, half overweight and half normal weight, will get either real or fake air purifiers in their homes. Researchers will track asthma symptoms to…

This study tests whether a symptom-driven inhaler (budesonide/formoterol) works better for teens with asthma who often forget their daily maintenance inhalers. Researchers will compare adherence and asthma flare-ups between the standard daily inhaler plus rescue inhaler group and…

This Phase 2 trial is testing dupilumab (Dupixent) in 17 people with aspirin-exacerbated respiratory disease (AERD), a condition that includes asthma, nasal polyps, and severe reactions to aspirin. The study aims to see if the drug can reduce markers of inflammation and improve s…

This study looks at whether people with asthma who often forget to take their daily maintenance inhaler might do better using an inhaler only when they have symptoms. Researchers will compare adherence and asthma flare-ups between two groups: one continuing daily maintenance inha…

This study tests whether vitamin D3 supplements can improve asthma control in adolescents aged 12-17 who have obesity, non-allergic asthma, and vitamin D deficiency. Participants receive either a high or standard daily dose of vitamin D3 for three months. Researchers will measure…

This Phase 3 trial tests dexpramipexole, an oral tablet, as an add-on treatment for people with eosinophilic asthma that is not well controlled. About 600 participants aged 12 and older will receive either the drug or a placebo for 24 weeks. The study measures improvements in lun…

This study aimed to compare two treatment options for adults with T2-high asthma that remains uncontrolled despite medium-dose inhaled steroids and long-acting beta agonists. One group would receive a higher dose of the same combination, while the other would add a third medicati…

This study tests whether giving pregnant women fish oil supplements can prevent asthma, eczema, and allergies in their children. 800 mothers took fish oil or a placebo from week 24 of pregnancy until one week after birth. The children are then followed for several years to see if…

This study tests whether giving mothers high-dose vitamin D (2400 IU daily) from week 24 of pregnancy until one week after birth can prevent asthma symptoms like wheezing in their children. 600 mothers from the ABC cohort in Denmark are participating. The children are followed fo…

This study tests whether giving omalizumab (Xolair) to 2-3 year olds at high risk for asthma for two years can prevent the disease from developing. 200 children are enrolled in a double-blind, placebo-controlled trial. After treatment, they are monitored for another two years to …

This study looks at whether giving C-section babies a dose of their mother's vaginal bacteria can help prevent allergies and asthma. Researchers believe that babies born by C-section miss out on beneficial bacteria that help train the immune system. The study involves 114 infants…

This study is testing whether a breathing retraining program can improve quality of life for 300 adults with uncontrolled asthma in Denmark. Participants will learn specific breathing techniques alongside their usual asthma care. The goal is to see if this approach is practical f…

This early-stage trial is testing an experimental drug called AMG 691 in 21 healthy volunteers and people with mild-to-moderate asthma. The main goal is to see if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as an injection und…

This study tests whether an online cognitive behavior therapy (CBT) program can help children aged 8 to 17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. The st…

This study tests a new device called SonoHeal that uses sound waves to help people with cystic fibrosis, bronchiectasis, or COPD clear mucus from their lungs. Fifteen participants will try the device at home to see if it is easy to use and acceptable. The study also compares it t…

This study planned to test whether osteopathic manipulative treatment (OMT) — a hands-on technique to improve chest movement — could reduce lung inflammation and improve breathing in adults with asthma. Researchers intended to measure inflammation using a nitric oxide breath test…

This study tests a digital tool called aflo™ that attaches to asthma inhalers and gives real-time feedback on how to use them correctly. It aims to see if the tool helps people with uncontrolled asthma improve their inhaler technique, medication adherence, and overall asthma cont…

This study tests a 3-month program that helps World Trade Center responders with asthma take better control of their condition. Participants work with a health coach and an asthma educator to improve medication use and daily management. The goal is to see if this approach improve…

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This early-stage study tests a new drug called APG777 in 31 adults with mild-to-moderate asthma. The main goal is to check if the drug is safe and how the body handles it. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug…

This study looks at whether teaching children with asthma special breathing exercises can improve their quality of life and help them be more active. About 40 kids aged 10-17 with asthma and poor breathing patterns will either get breathing training plus activity advice, or just …

This study aimed to see if giving children aged 2 to 8 a nebulized steroid called budesonide after an asthma emergency room visit could lower their chance of having another attack within a month. The plan was to compare budesonide plus standard oral steroids against oral steroids…

This pilot study tests whether tezepelumab, a drug already approved for severe asthma, can also reduce nasal symptoms caused by hayfever in people who have both allergic asthma and allergic rhinitis. Nineteen participants will receive monthly injections of tezepelumab for 12 mont…

This study investigates whether T2 biomarkers, measured in sputum, can predict which people with occupational asthma will go into remission after stopping exposure to workplace triggers. Only about 30% of patients currently recover, and there is no way to predict who will. Resear…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study looks at how dupilumab changes the way the nose and blood respond to house dust mites in adults with allergic asthma. Participants will be exposed to dust mites in a special chamber and receive either dupilumab or a placebo. The goal is to understand the drug's effects…

This study looks back at medical records of 197 adults in Israel who started benralizumab for severe asthma between 2019 and 2024. Researchers will count how many asthma attacks (exacerbations) patients had before and after starting the drug. The goal is to see how well benralizu…

This study tests a computer tool called eAMS-Eco that helps doctors choose asthma inhalers with a lower carbon footprint. The tool adds environmental information to existing asthma treatment recommendations. Researchers will see if using this tool in four clinics reduces inhaler-…

This study looks at how dupilumab, a drug for severe asthma, is actually used by patients in France. Researchers will analyze health records of about 35,000 people to describe their characteristics, healthcare costs, and steroid use before and after starting the drug. The goal is…

This study looks at whether educating doctors in small and mid-sized city hospitals can improve how they test and treat patients with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more patients get the right molecular tests and targeted treat…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study aims to improve how asthma is diagnosed and treated by developing new tests and targeted therapies. Researchers will enroll 60 adults with asthma to test a special oil additive and measure lung function and quality of life. The goal is to create better tools for managi…

This study follows 300 pregnant women who had respiratory infections to see if RSV can pass from mother to baby before birth. Researchers will test blood from mothers and umbilical cords for RSV antibodies and viruses. Babies will be tracked for up to 4 years to monitor respirato…

This long-term study recruited over 12,000 non-pregnant women in Southampton, UK, and followed about 3,000 of them through pregnancy and their children's growth up to age 19. Researchers are tracking body composition, nutrition, asthma, and heart health to understand how a mother…

This study watches 100 people with severe asthma who are taking biologic drugs. Researchers measure how the body reacts to the drug and whether it affects asthma attacks. The goal is to learn more about drug effectiveness and safety.

This study follows 202 Chinese asthma patients who are already prescribed biologic medications. Researchers will track how consistently patients take their biologics over 52 weeks and describe treatment patterns. No new drug is being tested; the goal is to gather real-world data …

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This study looks at whether mepolizumab, a drug already used to reduce asthma attacks, can also improve physical activity and exercise tolerance in people with severe asthma. Researchers will track daily steps and activity levels in 62 adults over six months. The goal is to see i…

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 participants over several years to track changes in lung function. The goal is to better understand why some patients struggle wi…

This study uses artificial intelligence and natural language processing to scan electronic health records and identify people with severe asthma. Researchers will compare the AI's findings to diagnoses made by doctors. The goal is to improve how severe asthma is detected and make…

This study follows 180 infants from birth to age 2 to see how bacteria in their upper airways change over time. Researchers want to learn if certain bacteria lead to more airway inflammation and lower lung function, which could increase asthma risk. The study does not test any tr…

This observational study is collecting data from 315 patients in Italy who started treatment with tezepelumab for severe uncontrolled asthma. The goal is to describe their characteristics, medical history, and how their asthma exacerbation rates change over 12 to 24 months. It is…

This study tracks 40 people with nasal polyps and severe asthma who are taking mepolizumab, a drug that reduces inflammation. Researchers collect nose, blood, and sputum samples before treatment and at 3, 6, and 12 months to see how the drug affects symptoms, nose bacteria, and g…

This study looks at how certain immune cells, called memory Th2 cells, that stay in the lungs may trigger allergic asthma attacks when a person breathes in allergens like cat or dust mite dander. Researchers will take samples from the airways of 37 people with mild to moderate al…

This study aimed to compare standard oxygen therapy with two different flow rates of high-flow nasal cannula in children aged 2-17 with moderate to severe asthma. The goal was to see if it was possible to enroll enough patients and measure breathing improvements. However, the stu…

This project works to make sure children with common respiratory infections get the right antibiotics for the right amount of time. It involves over 259,000 kids across many clinics. The goal is to learn the best ways to help doctors follow antibiotic guidelines and reduce unnece…

This study follows 200 adults in Taiwan who have bronchiectasis, a lung condition that causes widening of the airways and leads to repeated infections. Researchers will track their health problems, treatments, and how the disease changes over time. The goal is to learn more about…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study looks at 1,600 adults in Hong Kong who have been diagnosed with asthma or COPD to find out how many have both conditions (called Asthma-COPD Overlap). Researchers will track their health for 3 years to see how they do and whether their treatment matches guidelines. The…

This study planned to use a special camera (virtual navigation bronchoscopy) to collect samples from mucus plugs in the lungs of people with asthma. The goal was to compare inflammation markers between plugged and non-plugged airways, and with healthy volunteers. However, the stu…

This study follows 376 people aged 12 and older who are starting Dupixent for asthma in real-world clinics. Researchers will track their medical history, how they use the drug, and whether it improves lung function and reduces attacks. No new treatment is given—the goal is to lea…

This study follows 499 children from birth to age 6-7 to understand how early-life factors like allergens, pollution, and microbes may lead to asthma and allergies. Parents with asthma or hay fever are included. No treatments or changes are made—just observation to uncover root c…

This study tests a digital tool called AsthmaOptimiser that helps doctors assess asthma control and find ways to improve treatment during a single visit. About 746 adults with asthma who have had recent flare-ups will take part. The goal is to see if the tool can identify better …

This study tests whether giving patients an information sheet during a doctor's visit for a respiratory infection (like bronchitis, sinusitis, or sore throat) can lower antibiotic prescribing and improve communication. About 1,100 adults in Danish general practices will either re…

This study is refining a questionnaire to help doctors detect small airway dysfunction in people with COPD. Researchers will also compare two breathing tests (spirometry and oscillometry) to see which works better in primary care. About 108 adults with asthma, COPD, or both will …

This study looks at how air pollution and the body's internal clock (circadian rhythm) interact to worsen asthma, especially at night. Researchers will measure tiny molecules called microRNAs in the sputum of 20 adults with and without asthma over 48 hours. The goal is to underst…

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This study was designed to understand how the asthma drug terbutaline sulfate works in the body when given through a vein versus under the skin. Researchers planned to enroll adults with asthma to find the best dose. However, the trial was withdrawn before any participants were e…

This study aims to find biological markers in blood, saliva, and sputum that can predict how well patients with EGPA (a rare inflammatory disease) and severe asthma respond to the drug mepolizumab. Researchers will analyze proteins in these samples before and after treatment to u…

This study aimed to see if removing mucus plugs from the airways of people with asthma is safe and could improve lung function. Researchers planned to use a thin tube with a camera (bronchoscopy) to remove the plugs and then check breathing tests one week and six months later. Ho…

This study monitors indoor air quality in 500 French schoolchildren's classrooms, measuring pollutants like chemicals, allergens, and microbes. Researchers will track asthma and allergy symptoms using questionnaires and lung function tests. The goal is to understand how combinati…

This study looks at 150 preschool children (ages 1 to 5) hospitalized for a severe asthma attack. Researchers measure inflammation markers in blood and sputum, and check for viruses and bacteria. The goal is to see if different wheezing patterns have different underlying causes, …

This study looks at how breathing in low levels of ozone—similar to what you might encounter on a typical day in Chapel Hill—affects lung function and airway inflammation in adults with mild asthma. Researchers will compare ozone exposure to filtered air in 18 participants. The g…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study follows 192 toddlers aged 18 to 36 months who are at high risk for asthma due to wheezing episodes. Researchers track their health over time to understand how asthma develops in early childhood. The goal is to find better ways to prevent and treat asthma in the future.

This study aimed to see if COVID-19 makes asthma worse or harder to control. Researchers planned to compare asthma patients who had COVID-19 with those who did not, tracking lung function and symptoms for a year. However, the study was withdrawn before enrolling anyone, so no res…

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to understand how the disease progresses and what factors influence it. Researchers measure lung function, analyze mucus, and track environmental exposures like air pollution. The goal is…

This registry is collecting blood samples and health data from 400 people with neuroendocrine tumors. The goal is to see if a new blood test called NETest can help detect tumor activity and predict disease progression. Participants include patients before and after surgery, those…

This study looks at sleep quality in 60 adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Researchers will measure how well participants sleep and see if poor sleep is linked to more severe lung disease, worse breathing tests, or more lung damage on CT sca…

This study was designed to compare certain immune cells (called ILC2) in the lungs of children with severe asthma versus children without asthma. The goal was to see if these cells are higher in asthmatic children and if they relate to other markers of airway inflammation. Howeve…

This study is looking at over 10,000 smokers to find out if certain genes make some people more likely to develop COPD, a serious long-term lung disease. Participants are having their lung function tested and getting chest CT scans. The goal is to understand why some smokers get …

This study interviews and surveys 70 adolescents and adults with sickle cell disease to understand why they sometimes skip their daily medications. Researchers will also ask what kind of text-message reminders patients would find helpful. The goal is to design a better support sy…

This study follows 362 children with severe asthma to identify different types of the disease and what makes it worse. Researchers will track their health from childhood into adulthood to see how asthma changes over time. The goal is to find risk factors and improve treatment str…

This study examines whether children with asthma have different gut bacteria compared to healthy children. Researchers will collect stool samples from 20 children aged 6 to 9 with mild asthma. The goal is to understand how gut microbes might influence asthma, which could lead to …

This study is gathering information from adults with asthma to better understand the condition. Researchers will collect medical history and lung function data to create a database for future asthma research. The study does not test any new treatments or medications.

This observational study is looking at over 1,000 adults with asthma to better understand different types of the disease. Researchers will combine real-world medical records with genetic data to see how patients respond to various treatments. The goal is to identify asthma subtyp…