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Could a biologic drug free severe asthma patients from High-Dose steroids?

NCT ID NCT07713498

ENROLLING_BY_INVITATION Disease control Sponsor: Franciscus Gasthuis Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study looks at whether people with severe asthma who start taking tezepelumab can safely lower their dose of inhaled corticosteroids. Researchers will track steroid use, asthma control, and flare-ups over 12 months in a real-world setting. The goal is to see if tezepelumab can reduce the need for steroids and their side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tezepelumab, a biologic drug, combined with tapering of inhaled corticosteroids
What this could lead to
If successful, this could show that tezepelumab allows people with severe asthma to use lower doses of inhaled steroids, reducing side effects while keeping asthma under control.
What could go wrong
This is a small, real-world study without a control group, so results may not prove cause and effect. Tapering steroids might lead to more asthma attacks in some patients.

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE ASTHMA

Contacts and locations

Locations

  • Franciscus Gasthuis & Vlietland

    Rotterdam, South Holland, 3045PM, Netherlands

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