Scientists probe why tezepelumab doesn't stop all asthma attacks

NCT ID NCT06666504

Completed Knowledge-focused Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This observational study looks at why some people with severe asthma continue to have flare-ups even while taking tezepelumab, an approved treatment. Researchers will track 150 patients over a year, measuring changes in inflammatory cells and markers in blood and airways during an attack compared to stable periods. The goal is to better understand the underlying causes of these breakthrough exacerbations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tezepelumab
What this could lead to: If successful, this could help doctors understand why some patients still have asthma attacks on tezepelumab and potentially improve treatment strategies.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma Inflammation Pathologic Processes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE ASTHMA

Contacts and locations

Locations

Guys & St Thomas NHS Foundation Trust

London, London, SE1 7EH, United Kingdom

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Other studies related to the condition(s) this trial covers.