New shot could tame asthma Flare-Ups

NCT ID NCT06940141

Ongoing Disease control Sponsor: Connect Biopharm LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This Phase 2 trial tests whether adding rademikibart (a shot) to standard care can help adults and teens with asthma and type 2 inflammation avoid hospital visits or needing more steroids during an attack. About 160 participants will receive either the drug or a placebo. The main goal is to see if the drug reduces treatment failure within 28 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rademikibart (also known as CBP-201), given as a shot under the skin
What this could lead to: If it works, this could provide a new add-on treatment to reduce hospital visits and need for extra steroids during asthma attacks.
What could go wrong: This is an early Phase 2 trial with only 160 people, so results may not apply to everyone. The drug may not lower treatment failure rates or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute asthma asthma T2-high asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA ACUTE

Contacts and locations

Locations

Acad. Chapidze Emergency Cardiology Center LLC

Tbilisi, 0159, Georgia
Allergy & Asthma Specialists, P.S.C.

Owensboro, Kentucky, 42301, United States
Amicis Research Center

Valencia, California, 91355, United States
Bendigo Health

Bendigo, Victoria, 3550, Australia
Bradford Teaching Hospitals NHS Foundation Trust

Bradford, BD96RJ, United Kingdom
CEMER - Centro Medico de Enfermedades Respiratorias

San Juan Bautista, Buenos Aires, B1602, Argentina
Campbelltown Hospital

Campbelltown, New South Wales, 2560, Australia
Caucasus Medical Center

Tbilisi, 0159, Georgia
Centro de Diagnostico y Rehabilitación S.A. -CEDIR

Santa Fe, S3000, Argentina
Centro respiratorio Infantil

Rosario, Santa Fe Province, 2000, Argentina
Chesapeake Clinical Research, Inc.

White Marsh, Maryland, 21162, United States
Clinical Hospital Center "Dragisa Misovic - Dedinje"

Belgrade, 11040, Serbia
Clinical Hospital Center Zemun

Belgrade, 11080, Serbia
Clinical Research of Rock Hill

Rock Hill, South Carolina, 29732, United States
Columbus Clinical Services, LLC

Miami, Florida, 33215, United States
DCT- McAllen Primary Care Research, LLC dba Discovery Clinical Trials

McAllen, Texas, 78503, United States
Guy's and St Thomas' NHS Foundation Trust

London, SE1 7EH, United Kingdom
Health Center Uzice

Užice, 31000, Serbia
Health Synergy Clinical Research, LLC

West Palm Beach, Florida, 33407, United States
Hospital Italiano de Buenos Aires

Caba, Buenos Aires, C1199, Argentina
Hospital Universitario Austral

Pilar, Buenos Aires, B1629ODT, Argentina
INECO Neurociencias Oroño

Rosario, Santa Fe Province, S2000, Argentina
INSARES

Mendoza, 5500CCG, Argentina
Inquest Clinical Research

Baytown, Texas, 77521, United States
Institute for Pulmonary Diseases and Tuberculosis Nis

Niš, 18108, Serbia
Institute for Pulmonary Diseases of Vojvodina

Kamenitz, 21204, Serbia
Instituto Ave Pulmo-Fundacion Enfisema

Mar del Plata, Buenos Aires, 7600, Argentina
Investigaciones en Alergias y Enfermoedades Respiratorias (InAER)

Caba, Buenos Aires, C1425BEN, Argentina
Investigaciones en Patologias Respiratorias SRL

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
JSC "National Center for Lung Health"

Tbilisi, 0101, Georgia
Kings College Hospital NHS Foundation

London, SE5 9RS, United Kingdom
LLC "Israel-Georgian Medical Research Clinic Healthycore"

Tbilisi, 0112, Georgia
LLC Diacor

Tbilisi, 0159, Georgia
Leland Stanford Junior University, Stanford Hospital

Palo Alto, California, 94304, United States
Medicines Evaluation Unit Ltd.

Wythenshawe, Greater Manchester, M23 9QZ, United Kingdom
Nemours Children's Health

Jacksonville, Florida, 32207, United States
Nemours Children's Health, Lake Nona

Orlando, Florida, 32827, United States
Nemours Children's Hospital - DE

Wilmington, Delaware, 19803, United States
Norfolk and Norwich University Hospital NHS Foundation Trust

Norwich, Norfolk, NR4 7UY, United Kingdom
Pharmax Research of South Florida, Inc.

Miami, Florida, 33175, United States
Pivotal Research Solutions

Stonecrest, Georgia, 30038, United States
Premier Pulmonary Critical Care and Sleep Medicine

Denison, Texas, 75020, United States
Primeway Clinical Research Group

Fayetteville, Georgia, 30214, United States
Queensland Children's Hospital

South Brisbane, Queensland, 4101, Australia
Raymann, LLC

Tbilisi, 0186, Georgia
STAT Research

Caba, Buenos Aires, C1023, Argentina
Salford Royal Hospital - Northern Care Alliance NHS Foundation Trust Barnes Clinical Research Facility

Salford, Greater Manchester, M6 8HD, United Kingdom
St George Hospital, South Eastern Sydney Local Health District

Kogarah, New South Wales, 2217, Australia
St. Vincent's Hospital Sydney

Darlinghurst, New South Wales, 2010, Australia
The Canberra Hospital

Garran, Australian Capital Territory, 2605, Australia
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
University Clinical Center Kragujevac

Kragujevac, 34000, Serbia
University Hospitals Birmingham NHS Foundation Trust Birmingham Heartlands Hospital

Birmingham, B9 5SS, United Kingdom
University Hospitals Birmingham NHS Foundation Trust of Trust Headquarters Queen Elizabeth hospital Birmingham

Birmingham, B15 2GW, United Kingdom
University of Iowa

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
Vermont Lung Center

Colchester, Vermont, 05446, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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