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New asthma drug verekitug tested for Long-Term safety

NCT ID NCT06966479

Disease control Sponsor: Upstream Bio Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for adults with severe asthma who finished the earlier VALIANT trial. It tests the long-term safety and effectiveness of verekitug, a drug given as a shot. About 396 people are taking part. The main goal is to see if verekitug is safe over time and if it can reduce asthma attacks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Verekitug (also called UPB-101), given as a shot under the skin
What this could lead to
If it works, verekitug could offer a new long-term treatment option to reduce asthma attacks in people with severe asthma.
What could go wrong
This is a Phase 2 extension study, so it's still early. The drug may not prove safe or effective long-term, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

396 people

The number who actually took part.

Started

May 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Completion of the VALIANT study (UPB-CP-04 \[NCT06196879\]) per protocol. 2. Participant has signed, dated, and received a copy of the Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved written informed consent form (ICF) for the LTE study. 3. Contraceptive use by participants must be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. Exclusion Criteria: 1. Abnormal medical history, physical finding, or safety finding that in the opinion of the Investigator may obscure the study data or interfere with the participant's safety. 2. Any clinical laboratory test result outside of the reference ranges considered by the Investigator as clinically significant and that may obscure the study data or interfere with the participant's safety. 3. Participant with a history or evidence of a clinically significant pulmonary condition (other than asthma), including significant restrictive findings on pulmonary function testing, chronic bronchitis, emphysema, bronchiectasis, pulmonary fibrosis, or any other related condition that may obscure the study data (e.g., gastroesophageal reflux and vocal cord paralysis/dysfunction). 4. Pregnant or breastfeeding or planning to become pregnant or breastfeed during the study or unwilling to use adequate birth control, if of reproductive potential and sexually active. 5. Participants with significant protocol deviations in VALIANT, assessed at the discretion of the Sponsor. 6. Participant is unreliable, incapable of adhering to the protocol and visit schedule according to the judgment of the Investigator or has any disorder that may compromise their ability to give informed consent.

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Conditions

The condition(s) this trial relates to.

asthma bronchial disorder chronic asthma lung disorder respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Severe asthma

Contacts and locations

Locations

  • "Alergo-Med" Specjalistyczna Przychodnia Lekarska Spolka Z Ograniczona Odpowiedzialnoscia

    Tarnów, Malopolskie Voivodeship, 33-100, Poland

  • AA MRC

    Flint, Michigan, 48504, United States

  • ALL-MED Specjalistyczna Opieka Medyczna. Medyczny Instytut Badawczy Marek Jutel

    Wroclaw, Dolnoslaskie Voivodeship, 53-201, Poland

  • ATOPIA Niepubliczny Zakład Opieki Zdrowotnej Poradnie Specjalistyczne

    Krakow, Malopolskie Voivodeship, 31-141, Poland

  • Advance Pharma Research

    Cutler Bay, Florida, 33189, United States

  • Alina Clinical Trials, LLC

    Dallas, Texas, 75209, United States

  • Allergy & Asthma Clinical Research

    Walnut Creek, California, 94598, United States

  • Allergy & Immunology Unit, UCT Lung Institute

    Cape Town, Western Cape, 7700, South Africa

  • Allianz Research Institute

    Westminster, California, 92683, United States

  • Ambulatory For Specialized Outpatient Medical Care - Individual Practice - Dr. Nikolay Evgeniev Ruse Ltd

    Rousse, Ruse, 7000, Bulgaria

  • Asan Medical Center

    Seoul, Republic of Korea, 05505, South Korea

  • Ashford & St Peters Hospital

    Chertsey, Surrey, KT16 0PZ, United Kingdom

  • Bradford Royal Infirmary

    Bradford, West Yorkshire, BD9 6RJ, United Kingdom

  • CARE: Centro de Alergia y Enfermedades Respiratorias

    Buenos Aires, C1414AIF, Argentina

  • CIMER

    Ñuñoa, Santiago Metropolitan, 7770484, Chile

  • California Medical Research Associates Inc.

    Northridge, California, 91324, United States

  • California Medical Research Associates Inc.

    Houston, Texas, 77008, United States

  • Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust

    Cottingham, East Yorkshire, HU16 5JQ, United Kingdom

  • Centro Medico Dharma

    Mendoza, M5500, Argentina

  • Centro de Medicina Respiratoria

    Concepción del Uruguay, Entre Ríos Province, E3260, Argentina

  • Centrum Badan Klinicznych Piotr Napora lekarze Spp

    Wroclaw, Dolnoslaskie Voivodeship, 51-162, Poland

  • Centrum Medycyny Oddechowej, Mroz Spolka Jawna

    Bialystok, Podlaskie Voivodeship, 15-044, Poland

  • Centrum Medyczne "All-Med" Badania Kliniczne

    Krakow, Malopolskie Voivodeship, 30-033, Poland

  • Chesapeake Clinical Research Inc

    White Marsh, Maryland, 21162, United States

  • Chungbuk National University Hospital

    Taebuk, Republic of Korea, 28644, South Korea

  • Churchill Hospital - Centre for Clinical Vaccinology and Tropical Medicine (CCVTM)

    Oxford, OX3 7LE, United Kingdom

  • Clinical Site Partners dba Flourish research

    Winter Park, Florida, 32789, United States

  • Clinical Site Partners, LLC dba Flourish Research

    Miami, Florida, 33135, United States

  • DM Clinical Tomball

    Tomball, Texas, 77375, United States

  • Dynamic Drug Advancement

    Ajax, Ontario, L1S 2J5, Canada

  • Edward Jenner Research Group, LLC

    Plantation, Florida, 33317, United States

  • El Paso Pulmonary Association

    El Paso, Texas, 79902, United States

  • Emmed Research

    Pretoria, Gauteng, 0002, South Africa

  • Estudios Clínicos de Enfermedades Respiratorias e Inmunológicas (CIERI)

    Valparaíso, Valparaiso, 2531172, Chile

  • Eunpyeong St. Marys Hospital

    Seoul, South Korea, 03312, South Korea

  • Fukuwa Clinic

    Tokyo, Tokyo, 104-0031, Japan

  • Fundacion Cidea

    CABA, Argentina, C1121ABE, Argentina

  • Fundacion Medica San Cristobal

    Santiago, Santiago Metropolitan, 7630226, Chile

  • Fundacion Scherbovsky

    Mendoza, Mendoza Province, 5500, Argentina

  • Gannochy Research Suite, Perth Royal Infirmary

    Perth, Tayside, PH1 1NX, United Kingdom

  • Gartnavel General Hospital (Glasgow Clinical Research Facility)

    Glasgow, Scotland, G12 0YN, United Kingdom

  • Health and Life Research Institute, LLC

    Miami, Florida, 33176, United States

  • Horizon Clinical Research

    Cypress, Texas, 77429, United States

  • Hospital Gregorio Marañon

    Madrid, Madrid, 28007, Spain

  • IKF Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases

    Hessen, Germany, 60596, Germany

  • IKF Pneumologie GmbH & Co. KG

    Mainz, 55128, Germany

  • INSARES

    Mendoza, 5500, Argentina

  • Instituto Especialidades de la Salud Rosario

    Santa Fe, 2000, Argentina

  • Instituto de Medicina Respiratoria, IMeR/ Instituto Médico DAMIC

    Córdoba, Córdoba Province, X5003DCE, Argentina

  • Integrated Research of Inland Inc

    Upland, California, 91786, United States

  • Investigaciones En Patologias Respiratorias

    San Miguel de Tucumán, Tucumán Province, CP T4000IAP, Argentina

  • Investigaciones en Alergias y Enfermedades Respiratorias-InAER

    Buenos Aires, Argentina

  • KPPK Studienzentrum

    Bendorf, 56170, Germany

  • Kern Research, Inc.

    Bakersfield, California, 93301, United States

  • Kishiwada City Hospital

    Osaka, Japan, 596-8501, Japan

  • Kyung Hee University Hospital

    Seoul, Republic of Korea, 02447, South Korea

  • M3 Wake Research

    Las Vegas, Nevada, 89106, United States

  • MC Convex/DCC Convex

    Sofia, Sofia, 1680, Bulgaria

  • MC Zdrave 1

    Kozloduy, Vratsa, 3320, Bulgaria

  • ME Clinical Respiratory Research Hamburg GmbH

    Hamburg, Free and Hanseatic City of Hamburg, 22299, Germany

  • MHAT "Rahila Angelova" Pernik

    Pernik, Pernik, 2300, Bulgaria

  • Małopolskie Centrum Alergologii Spółka z ograniczoną odpowiedzialnością

    Krakow, Malopolskie Voivodeship, 31-624, Poland

  • Medical Center Excelsior (Todor Popov)

    Sofia, Sofia, 1407, Bulgaria

  • Medical Center HERA EOOD

    Sofia, 1510, Bulgaria

  • Medical Center New Rehabilitation Center EOOD

    Stara Zagora, Stara Zagora, 6001, Bulgaria

  • Medical center Pulmovizhyn

    Sofia, 1756, Bulgaria

  • Metroplex Pulmonary and Sleep Center Drive

    McKinney, Texas, 75069, United States

  • Municipal Non-Profit Enterprise "Center for Infectious Diseases of the Ivano-Frankivsk Regional Council"

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine

  • NZOZ J. Małolepszy i Partnerzy

    Wroclaw, Dolnoslaskie Voivodeship, 54-239, Poland

  • National Hospital Organization Ibarakihigashi National Hospital

    Ibaraki, Osaka, 319-1113, Japan

  • Newtown CRC

    Newtown, Johannesburg, 2001, South Africa

  • Nouvelle Clinical Research

    Miami, Florida, 33189, United States

  • OK Clinical Research, LLC

    Edmond, Oklahoma, 73034, United States

  • Office of Hector H. Altieri MD

    San Miguel de Tucumán, 4000, Argentina

  • Oji General Hospital

    Hokkaido, Hokkaido, 053-8506, Japan

  • Osaka Habikino Medical Center

    Osaka, Japan, 583-8588, Japan

  • Osaka Metropolitan University Hospital

    Osaka, Osaka, 545-0051, Japan

  • Ostrowieckie Centrum Medyczne spolka cywilna Anna Olech-Cudzik, Krzysztof Cudzik

    Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland

  • POIS Sachsen GmbH

    Leipzig, Germany, 04347, Germany

  • Pectus Respiratory Health

    Barcelona, Catalonia, 08017, Spain

  • Phoenix Medical Research

    Miami, Florida, 33165, United States

  • Plicni Stredisko Teplice S.R.O

    Teplice, 415 01, Czechia

  • Prywatny Gabinet Lekarski Malgorzata Pawlukiewicz

    Rzeszów, Podkarpackie Voivodeship, 35-051, Poland

  • Pulmonary Research Institute of Southeast Michigan (PRISM)

    Farmington Hills, Michigan, 48336, United States

  • R&B Medical Center

    Tampa, Florida, 33614, United States

  • RCMS/Lungenpraxis Hohenzollerndamm

    Berlin, Germany, 10717, Germany

  • Regional Communal Nonprofit Institution "Chernivtsi Regional Clinical Hospital"

    Chernivtsi, Chernivtsi Oblast, 58000, Ukraine

  • Research Institute of South Florida

    Miami, Florida, 33173, United States

  • Samsung Medical Center

    Seoul, Republic of Korea, 06351, South Korea

  • Seoul National University Hospital

    Seoul, Republic of Korea, 03080, South Korea

  • Sociedad medica Sy G Limitada

    Providencia, Santiago Metropolitana, CHL 7501126, Chile

  • St Augustine's Hospital/Dr. IA Abdullah

    Durban, KwaZulu-Natal, 4001, South Africa

  • Synapta Clinical Research Centre

    Durban, KwaZulu-Natal, 4001, South Africa

  • The Catholic University of Korea, Seoul St. Marys Hospital

    Seoul, Republic of Korea, 06591, South Korea

  • Tokyo-Eki Center-building Clinic

    Tokyo, Chuo-ku, 103-0027, Japan

  • Toledo Institute of Clinical Research Inc

    Toledo, Ohio, 43617, United States

  • Treasure Valley Medical Research

    Boise, Idaho, 83706, United States

  • UOC Pneumologia AOU Renato Dulbecco

    Catanzaro, Catanzaro, 88100, Italy

  • Uniwersyteckie Centrum Kliniczne, Klinika Alergologii i Pneumonologii

    Gdansk, Pomorskie Voivodeship, 80-214, Poland

  • Urban Health Plan INC

    The Bronx, New York, 10459, United States

  • Yeungnam University Hospital

    Daegu, Republic of Korea, 42415, South Korea

  • Yonsei University Health System - Severance Hospital

    Seoul, Republic of Korea, 03722, South Korea

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