New asthma drug verekitug tested for Long-Term safety

NCT ID NCT06966479

Ongoing Disease control Sponsor: Upstream Bio Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for adults with severe asthma who finished the earlier VALIANT trial. It tests the long-term safety and effectiveness of verekitug, a drug given as a shot. About 396 people are taking part. The main goal is to see if verekitug is safe over time and if it can reduce asthma attacks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Verekitug (also called UPB-101), given as a shot under the skin
What this could lead to: If it works, verekitug could offer a new long-term treatment option to reduce asthma attacks in people with severe asthma.
What could go wrong: This is a Phase 2 extension study, so it's still early. The drug may not prove safe or effective long-term, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma bronchial disorder chronic asthma lung disorder respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE ASTHMA

Contacts and locations

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Locations

"Alergo-Med" Specjalistyczna Przychodnia Lekarska Spolka Z Ograniczona Odpowiedzialnoscia

Tarnów, Malopolskie Voivodeship, 33-100, Poland
AA MRC

Flint, Michigan, 48504, United States
ALL-MED Specjalistyczna Opieka Medyczna. Medyczny Instytut Badawczy Marek Jutel

Wroclaw, Dolnoslaskie Voivodeship, 53-201, Poland
ATOPIA Niepubliczny Zakład Opieki Zdrowotnej Poradnie Specjalistyczne

Krakow, Malopolskie Voivodeship, 31-141, Poland
Advance Pharma Research

Cutler Bay, Florida, 33189, United States
Alina Clinical Trials, LLC

Dallas, Texas, 75209, United States
Allergy & Asthma Clinical Research

Walnut Creek, California, 94598, United States
Allergy & Immunology Unit, UCT Lung Institute

Cape Town, Western Cape, 7700, South Africa
Allianz Research Institute

Westminster, California, 92683, United States
Ambulatory For Specialized Outpatient Medical Care - Individual Practice - Dr. Nikolay Evgeniev Ruse Ltd

Rousse, Ruse, 7000, Bulgaria
Asan Medical Center

Seoul, Republic of Korea, 05505, South Korea
Ashford & St Peters Hospital

Chertsey, Surrey, KT16 0PZ, United Kingdom
Bradford Royal Infirmary

Bradford, West Yorkshire, BD9 6RJ, United Kingdom
CARE: Centro de Alergia y Enfermedades Respiratorias

Buenos Aires, C1414AIF, Argentina
CIMER

Ñuñoa, Santiago Metropolitan, 7770484, Chile
California Medical Research Associates Inc.

Northridge, California, 91324, United States
California Medical Research Associates Inc.

Houston, Texas, 77008, United States
Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust

Cottingham, East Yorkshire, HU16 5JQ, United Kingdom
Centro Medico Dharma

Mendoza, M5500, Argentina
Centro de Medicina Respiratoria

Concepción del Uruguay, Entre Ríos Province, E3260, Argentina
Centrum Badan Klinicznych Piotr Napora lekarze Spp

Wroclaw, Dolnoslaskie Voivodeship, 51-162, Poland
Centrum Medycyny Oddechowej, Mroz Spolka Jawna

Bialystok, Podlaskie Voivodeship, 15-044, Poland
Centrum Medyczne "All-Med" Badania Kliniczne

Krakow, Malopolskie Voivodeship, 30-033, Poland
Chesapeake Clinical Research Inc

White Marsh, Maryland, 21162, United States
Chungbuk National University Hospital

Taebuk, Republic of Korea, 28644, South Korea
Churchill Hospital - Centre for Clinical Vaccinology and Tropical Medicine (CCVTM)

Oxford, OX3 7LE, United Kingdom
Clinical Site Partners dba Flourish research

Winter Park, Florida, 32789, United States
Clinical Site Partners, LLC dba Flourish Research

Miami, Florida, 33135, United States
DM Clinical Tomball

Tomball, Texas, 77375, United States
Dynamic Drug Advancement

Ajax, Ontario, L1S 2J5, Canada
Edward Jenner Research Group, LLC

Plantation, Florida, 33317, United States
El Paso Pulmonary Association

El Paso, Texas, 79902, United States
Emmed Research

Pretoria, Gauteng, 0002, South Africa
Estudios Clínicos de Enfermedades Respiratorias e Inmunológicas (CIERI)

Valparaíso, Valparaiso, 2531172, Chile
Eunpyeong St. Marys Hospital

Seoul, South Korea, 03312, South Korea
Fukuwa Clinic

Tokyo, Tokyo, 104-0031, Japan
Fundacion Cidea

CABA, Argentina, C1121ABE, Argentina
Fundacion Medica San Cristobal

Santiago, Santiago Metropolitan, 7630226, Chile
Fundacion Scherbovsky

Mendoza, Mendoza Province, 5500, Argentina
Gannochy Research Suite, Perth Royal Infirmary

Perth, Tayside, PH1 1NX, United Kingdom
Gartnavel General Hospital (Glasgow Clinical Research Facility)

Glasgow, Scotland, G12 0YN, United Kingdom
Health and Life Research Institute, LLC

Miami, Florida, 33176, United States
Horizon Clinical Research

Cypress, Texas, 77429, United States
Hospital Gregorio Marañon

Madrid, Madrid, 28007, Spain
IKF Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases

Hessen, Germany, 60596, Germany
IKF Pneumologie GmbH & Co. KG

Mainz, 55128, Germany
INSARES

Mendoza, 5500, Argentina
Instituto Especialidades de la Salud Rosario

Santa Fe, 2000, Argentina
Instituto de Medicina Respiratoria, IMeR/ Instituto Médico DAMIC

Córdoba, Córdoba Province, X5003DCE, Argentina
Integrated Research of Inland Inc

Upland, California, 91786, United States
Investigaciones En Patologias Respiratorias

San Miguel de Tucumán, Tucumán Province, CP T4000IAP, Argentina
Investigaciones en Alergias y Enfermedades Respiratorias-InAER

Buenos Aires, Argentina
KPPK Studienzentrum

Bendorf, 56170, Germany
Kern Research, Inc.

Bakersfield, California, 93301, United States
Kishiwada City Hospital

Osaka, Japan, 596-8501, Japan
Kyung Hee University Hospital

Seoul, Republic of Korea, 02447, South Korea
M3 Wake Research

Las Vegas, Nevada, 89106, United States
MC Convex/DCC Convex

Sofia, Sofia, 1680, Bulgaria
MC Zdrave 1

Kozloduy, Vratsa, 3320, Bulgaria
ME Clinical Respiratory Research Hamburg GmbH

Hamburg, Free and Hanseatic City of Hamburg, 22299, Germany
MHAT "Rahila Angelova" Pernik

Pernik, Pernik, 2300, Bulgaria
Małopolskie Centrum Alergologii Spółka z ograniczoną odpowiedzialnością

Krakow, Malopolskie Voivodeship, 31-624, Poland
Medical Center Excelsior (Todor Popov)

Sofia, Sofia, 1407, Bulgaria
Medical Center HERA EOOD

Sofia, 1510, Bulgaria
Medical Center New Rehabilitation Center EOOD

Stara Zagora, Stara Zagora, 6001, Bulgaria
Medical center Pulmovizhyn

Sofia, 1756, Bulgaria
Metroplex Pulmonary and Sleep Center Drive

McKinney, Texas, 75069, United States
Municipal Non-Profit Enterprise "Center for Infectious Diseases of the Ivano-Frankivsk Regional Council"

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
NZOZ J. Małolepszy i Partnerzy

Wroclaw, Dolnoslaskie Voivodeship, 54-239, Poland
National Hospital Organization Ibarakihigashi National Hospital

Ibaraki, Osaka, 319-1113, Japan
Newtown CRC

Newtown, Johannesburg, 2001, South Africa
Nouvelle Clinical Research

Miami, Florida, 33189, United States
OK Clinical Research, LLC

Edmond, Oklahoma, 73034, United States
Office of Hector H. Altieri MD

San Miguel de Tucumán, 4000, Argentina
Oji General Hospital

Hokkaido, Hokkaido, 053-8506, Japan
Osaka Habikino Medical Center

Osaka, Japan, 583-8588, Japan
Osaka Metropolitan University Hospital

Osaka, Osaka, 545-0051, Japan
Ostrowieckie Centrum Medyczne spolka cywilna Anna Olech-Cudzik, Krzysztof Cudzik

Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland
POIS Sachsen GmbH

Leipzig, Germany, 04347, Germany
Pectus Respiratory Health

Barcelona, Catalonia, 08017, Spain
Phoenix Medical Research

Miami, Florida, 33165, United States
Plicni Stredisko Teplice S.R.O

Teplice, 415 01, Czechia
Prywatny Gabinet Lekarski Malgorzata Pawlukiewicz

Rzeszów, Podkarpackie Voivodeship, 35-051, Poland
Pulmonary Research Institute of Southeast Michigan (PRISM)

Farmington Hills, Michigan, 48336, United States
R&B Medical Center

Tampa, Florida, 33614, United States
RCMS/Lungenpraxis Hohenzollerndamm

Berlin, Germany, 10717, Germany
Regional Communal Nonprofit Institution "Chernivtsi Regional Clinical Hospital"

Chernivtsi, Chernivtsi Oblast, 58000, Ukraine
Research Institute of South Florida

Miami, Florida, 33173, United States
Samsung Medical Center

Seoul, Republic of Korea, 06351, South Korea
Seoul National University Hospital

Seoul, Republic of Korea, 03080, South Korea
Sociedad medica Sy G Limitada

Providencia, Santiago Metropolitana, CHL 7501126, Chile
St Augustine's Hospital/Dr. IA Abdullah

Durban, KwaZulu-Natal, 4001, South Africa
Synapta Clinical Research Centre

Durban, KwaZulu-Natal, 4001, South Africa
The Catholic University of Korea, Seoul St. Marys Hospital

Seoul, Republic of Korea, 06591, South Korea
Tokyo-Eki Center-building Clinic

Tokyo, Chuo-ku, 103-0027, Japan
Toledo Institute of Clinical Research Inc

Toledo, Ohio, 43617, United States
Treasure Valley Medical Research

Boise, Idaho, 83706, United States
UOC Pneumologia AOU Renato Dulbecco

Catanzaro, Catanzaro, 88100, Italy
Uniwersyteckie Centrum Kliniczne, Klinika Alergologii i Pneumonologii

Gdansk, Pomorskie Voivodeship, 80-214, Poland
Urban Health Plan INC

The Bronx, New York, 10459, United States
Yeungnam University Hospital

Daegu, Republic of Korea, 42415, South Korea
Yonsei University Health System - Severance Hospital

Seoul, Republic of Korea, 03722, South Korea

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