New combo therapy aims to stop lung cancer return after surgery

NCT ID NCT04564157

Ongoing Disease control Sponsor: Fundación GECP Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase III trial tests whether adding immunotherapy to standard chemotherapy after lung cancer surgery can delay or prevent the cancer from coming back. It enrolls 210 patients with stage IB-IIIA non-small cell lung cancer that was completely removed. Participants are randomly assigned to receive either chemotherapy alone or chemotherapy followed by maintenance immunotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carboplatin and Paclitaxel (chemotherapy) plus immunotherapy
What this could lead to: If successful, this could show that adding immunotherapy after surgery and chemotherapy helps keep lung cancer from coming back longer than chemotherapy alone.
What could go wrong: This is a Phase III trial, but results are not yet available. Adding immunotherapy may increase side effects without guaranteeing better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bronchogenic carcinoma lung disorder non-small cell lung carcinoma respiratory tract neoplasm Thoracic Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADJUVANT CHEMOTHERAPY NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Complejo Hospitalario de Navarra

Pamplona, Pamplona, 31008, Spain
Complexo Hospitalario Universitario De Vigo

Vigo, Vigo, 36204, Spain
Hospital Clínico San Carlos

Madrid, Madrid, 28040, Spain
Hospital Clínico de Valencia

Valencia, Valencia, 46010, Spain
Hospital Fundación de Alcorcón

Madrid, Madrid, 28922, Spain
Hospital General Universitario de Alicante

Alicante, Alicante, 03010, Spain
Hospital General Universitario de Valencia

Valencia, Valencia, 46014, Spain
Hospital Parc Taulí

Barcelona, Barcelona, 08208, Spain
Hospital Puerta de Hierro

Madrid, Madrid, 28222, Spain
Hospital San Pedro De Alcántara

Cáceres, Cáceres, 10003, Spain
Hospital Son Espases

Palma de Mallorca, Palma de Mallorca, 07120, Spain
Hospital Universitari Quiron Dexeus

Barcelona, Barcelona, 08028, Spain
Hospital Universitari Vall d' Hebron

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Cruces

Barakaldo, Vizcaya, 48903, Spain
Hospital Universitario Fundación Jiménez Díaz

Madrid, Madrid, 28040, Spain
Hospital Universitario Insular de Gran canaria

Las Palmas de Gran Canaria, Gran Canaria, 35016, Spain
Hospital Universitario La Fe

Valencia, Valencia, 46026, Spain
Hospital Universitario Lucus Augusti

Lugo, Lugo, 27003, Spain
Hospital Universitario Nuestra Señora La Candelaria

Santa Cruz de Tenerife, Santa Cruz de Tenerife, 38009, Spain
Hospital Universitario Virgen de la Arrixaca

El Palmar, El Palmar, 30120, Spain
Hospital Universitario de Jaén

Jaén, Jaén, 23007, Spain
Hospital Universitario la Paz

Madrid, Madrid, 28046, Spain
Hospital Virgen del Rocío

Seville, Sevilla, 41013, Spain
Hospital de Basurto

Bilbao, Bilbao, 48013, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Barcelona, 08041, Spain
Hospitalario Universitario A Coruña

A Coruña, La Coruña, 15006, Spain
ICO Badalona, Hospital Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain
ICO Girona, Hospital Josep Trueta

Girona, Girona, 17007, Spain
ICO Hospitalet

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Instituto Valenciano De Oncología

Valencia, Valencia, 46009, Spain

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