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New asthma drug WIN378 aims to calm lung inflammation in phase 2 trial

NCT ID NCT07120503

Disease control Sponsor: Windward Bio Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new medicine, WIN378, for adults with moderate or severe asthma. WIN378 blocks a protein that causes lung inflammation, which may improve asthma control. About 136 participants will receive either WIN378 or a placebo to check safety, how the drug works in the body, and its effect on breathing and asthma symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 136 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written Informed Consent Form * Females that are not pregnant or breastfeeding with following condition: not a woman of childbearing potential or woman of childbearing potential using a highly effective contraception method * Physician-diagnosis of asthma and documented evidence of airway reversibility during prior 24 months or during screening * Airflow limitation as indicated by pre-BD FEV1 value of ≥ 30% and ≤ 90%, predicted at two visits at Screening * Low, medium-, or high-dose ICS and ≥1 maintenance asthma controller medication (LABA/LTRA/LAMA/chromones/theophylline) Exclusion Criteria: * Participants with a known, pre-existing, clinically important lung condition other than asthma * Active tuberculosis or treatment required for tuberculosis within 12 months * Current or former smokers ≥10 pack years * History of cancer * Receipt of any marketed biologic agent within 4 months or 5 half-lives prior to screening; receipt of immunoglobulin or blood products within 30 days prior to screening or during the Screening Run-in period; receipt of any live or attenuated vaccines within 15 days prior to screening * Helminth infection within 24 weeks prior to screening * Use of immunosuppressive medication within 3 months prior to Screening Visit or during the Screening Run-in period * Participants who are pregnant, lactating or breastfeeding

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Conditions

The condition(s) this trial relates to.

asthma bronchial disorder disease lung disorder respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma (diagnosis)

Contacts and locations

Locations

  • WB Contracted Clinical Research Site

    Málaga, Málaga, 29010, Spain

  • WB Contracted Clinical Research Site

    Seville, Sevilla, 41012, Spain

  • WB Contracted Clinical Research Site

    Linköping, Ostergotlands, 587 58, Sweden

  • WB Contracted Clinical Research Site

    Malmö, Skåne County, 20512, Sweden

  • WB Contracted Clinical Research Site

    Stockholm, Stockholm County, 11239, Sweden

  • WB Contracted Clinical Research Site

    Los Angeles, California, 90025-7014, United States

  • WB Contracted Clinical Research Site

    San Jose, California, 95117, United States

  • WB Contracted Clinical Research Site

    Melbourne, Florida, 32763, United States

  • WB Contracted Clinical Research Site

    Miami, Florida, 33175, United States

  • WB Contracted Clinical Research Site

    White Marsh, Maryland, 21162, United States

  • WB Contracted Clinical Research Site

    Stow, Massachusetts, 01775-1205, United States

  • WB Contracted Clinical Research Site

    Detroit, Michigan, 48202-2608, United States

  • WB Contracted Clinical Research Site

    Richfield, Minnesota, 55423-2477, United States

  • WB Contracted Clinical Research Site

    St Louis, Missouri, 98119, United States

  • WB Contracted Clinical Research Site

    Bellevue, Nebraska, 68123, United States

  • WB Contracted Clinical Research Site

    Toledo, Ohio, 43560, United States

  • WB Contracted Clinical Research Site

    Edmond, Oklahoma, 73034, United States

  • WB Contracted Clinical Research Site

    Pittsburgh, Pennsylvania, 15213-3236, United States

  • WB Contracted Clinical Research Site

    Charleston, South Carolina, 29420, United States

  • WB Contracted Clinical Research Site

    Spartanburg, South Carolina, 29303, United States

  • WB Contracted Clinical Research Site

    Austin, Texas, 78730, United States

  • WB Contracted Clinical Research Site

    El Paso, Texas, 79903, United States

  • WB Contracted Clinical Research Site

    McKinney, Texas, 75069-8085, United States

  • WB Contracted Clinical Research Site

    San Antonio, Texas, 78229, United States

  • WB Contracted Clinical Research Site

    Tyler, Texas, 75708-3154, United States

  • WB Contracted Clinical Research Site

    Richmond, Virginia, 23226, United States

  • WB Contracted Clinical Research Site

    Buenos Aires, Buenos Aires F.D., C1023AAB, Argentina

  • WB Contracted Clinical Research Site

    Buenos Aires, Buenos Aires F.D., C1121ABE, Argentina

  • WB Contracted Clinical Research Site

    Buenos Aires, Buenos Aires F.D., C1414AIF, Argentina

  • WB Contracted Clinical Research Site

    Buenos Aires, Buenos Aires F.D., C1425BEN, Argentina

  • WB Contracted Clinical Research Site

    Buenos Aires, Buenos Aires F.D., C1425FVH, Argentina

  • WB Contracted Clinical Research Site

    Buenos Aires, Buenos Aires F.D., C1426ABP, Argentina

  • WB Contracted Clinical Research Site

    Córdoba, Córdoba Province, X5003DCE, Argentina

  • WB Contracted Clinical Research Site

    Paraná, Entre Ríos Province, E3102ADP, Argentina

  • WB Contracted Clinical Research Site

    Rosario, Santa Fe Province, S2000BRH, Argentina

  • WB Contracted Clinical Research Site

    Rosario, Santa Fe Province, S2013KZD, Argentina

  • WB Contracted Clinical Research Site

    Santa Fe, Santa Fe Province, S3000ASF, Argentina

  • WB Contracted Clinical Research Site

    San Miguel de Tucumán, Tucumán Province, T4000CBC, Argentina

  • WB Contracted Clinical Research Site

    San Miguel de Tucumán, Tucumán Province, T4000IAP, Argentina

  • WB Contracted Clinical Research Site

    San Miguel de Tucumán, Tucumán Province, T4000IFL, Argentina

  • WB Contracted Clinical Research Site

    Brookvale, New South Wales, 2100, Australia

  • WB Contracted Clinical Research Site

    Coffs Harbour, New South Wales, 2450, Australia

  • WB Contracted Clinical Research Site

    Maroubra, New South Wales, 2035, Australia

  • WB Contracted Clinical Research Site

    Miranda, New South Wales, 2228, Australia

  • WB Contracted Clinical Research Site

    Wollongong, New South Wales, 2500, Australia

  • WB Contracted Clinical Research Site

    Birtinya, Queensland, 4575, Australia

  • WB Contracted Clinical Research Site

    North Altona, Victoria, 3025, Australia

  • WB Contracted Clinical Research Site

    Sofia, Grad Sofia, 1407, Bulgaria

  • WB Contracted Clinical Research Site

    Lovech, Lovech, 5500, Bulgaria

  • WB Contracted Clinical Research Site

    Rousse, Ruse, 7000, Bulgaria

  • WB Contracted Clinical Research Site

    Sofia, Sofia, 1233, Bulgaria

  • WB Contracted Clinical Research Site

    Sofia, Sofia, 1680, Bulgaria

  • WB Contracted Clinical Research Site

    Pessac, Bordeaux, 33000, France

  • WB Contracted Clinical Research Site

    Dijon, Côte-dOr, 21000, France

  • WB Contracted Clinical Research Site

    Montpellier, Hérault, 34090, France

  • WB Contracted Clinical Research Site

    La Tronche, Isère, 38700, France

  • WB Contracted Clinical Research Site

    Nantes, Loire-Atlantique, 44093, France

  • WB Contracted Clinical Research Site

    Berlin, Loire-Atlantique, 10119, Germany

  • WB Contracted Clinical Research Site

    München, Loire-Atlantique, 80539, Germany

  • WB Contracted Clinical Research Site

    Bendorf, Rhineland-Palatinate, 56170, Germany

  • WB Contracted Clinical Research Site

    Lübeck, Schleswig-Holstein, 23552, Germany

  • WB Contracted Clinical Research Site

    Darmstadt, 64283, Germany

  • WB Contracted Clinical Research Site

    Frankfurt am Main, 60389, Germany

  • WB Contracted Clinical Research Site

    Frankfurt am Main, 60596, Germany

  • WB Contracted Clinical Research Site

    Leipzig, 4347, Germany

  • WB Contracted Clinical Research Site

    Mainz, 55128, Germany

  • WB Contracted Clinical Research Site

    München, 81241, Germany

  • WB Contracted Clinical Research Site

    Chiclana de la Frontera, Cádiz, 11139, Spain

  • WB Contracted Clinical Research Site

    Madrid, Entre Ríos, 28003, Spain

  • WB Contracted Clinical Research Site

    San Sebastián, Guipúzcoa, 20014, Spain

  • WB Contracted Clinical Research Site

    Madrid, Madrid, 28050, Spain

  • WB Contracted Clinical Research Site

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • WB Contracted Clinical Research Site

    Benalmádena, Málaga, 29639, Spain

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