Bronchial disorder

This study tests an experimental drug called lebrikizumab in teenagers aged 12 to 17 whose asthma is not well controlled even with daily inhalers and a second medication. Participants receive either lebrikizumab or a placebo as a shot every 4 weeks for a year, while continuing th…

This study investigates whether a 5-day course of oral azithromycin can reduce wheezing severity in preschool children (18 months to under 5 years) who come to the emergency department with a severe wheezing episode. Children are randomly assigned to receive either azithromycin o…

This Phase 3 trial tests whether tezepelumab, an injectable biologic, can help adults with severe asthma reduce their daily dose of oral corticosteroids while still keeping their asthma under control. Participants receive either tezepelumab or a placebo for 28 weeks, and doctors …

This phase 3 trial tests whether adding the chemotherapy drug carboplatin to standard palliative radiotherapy helps control tumor growth and reduce pain better than radiotherapy alone. The study includes adults with advanced lung or head and neck cancer who need palliative radiat…

This phase 2 study tested an experimental oral drug called RPT193 in 38 adults with moderate-to-severe asthma that was not fully controlled by standard inhalers. The goal was to see if RPT193 could reduce asthma attacks and improve lung function. The trial was terminated early, s…

This phase 3 study tested a new drug called pralsetinib against standard chemotherapy for people with a specific type of advanced lung cancer that has a RET gene fusion. The goal was to see if pralsetinib could better delay cancer growth. The trial was terminated early, so full r…

This phase 3 study tested the drug benralizumab in 295 adults with severe nasal polyps and eosinophilic chronic sinusitis. Participants received injections of benralizumab or a placebo every 4 to 8 weeks for about a year. The goal was to see if the drug could shrink polyps and im…

This study tested two doses of an inhaled drug called CHF6001 (Tanimilast) added to standard triple therapy in people with severe COPD and chronic bronchitis. The goal was to see if it could reduce the number of moderate or severe flare-ups over a year. The trial was terminated e…

This trial tested the drug Cayston (aztreonam lysine) in adults with bronchiectasis, a chronic lung disease causing cough and infections. The goal was to see if it could safely delay or reduce lung flare-ups. However, the study was stopped early and only enrolled 34 people, so we…

This study tested whether a drug called tiotropium works as well as inhaled steroids for children aged 6 to 11 with mild asthma that is not linked to allergies. Many children with non-allergic asthma do not respond well to steroids, so researchers wanted to see if tiotropium alon…

This study tested an experimental inhaler (CHF6001) added to standard asthma medicines in 517 adults with uncontrolled asthma. The goal was to see if it could reduce severe asthma attacks over one year. The trial was stopped early, and results are not yet available.

This study looked at the long-term safety of dexpramipexole in adults with severe eosinophilic asthma. Participants had already completed earlier phase 3 trials. The goal was to track side effects and asthma control over time. However, the study was terminated early, which may li…

This study tested a daily pill called dexpramipexole in 654 people with severe eosinophilic asthma, a type of asthma linked to high levels of certain white blood cells. The goal was to see if the drug could reduce severe asthma attacks over a year. However, the trial was terminat…

This study tested an inhaled drug called CHF6001 (Tanimilast) in people with COPD and chronic bronchitis who were already on triple therapy. The goal was to see if adding this drug could reduce flare-ups. The trial was stopped early and involved about 4,700 participants.

This Phase 3 trial tested dexpramipexole, an oral drug, in over 1,000 people with severe eosinophilic asthma that was not well controlled by standard treatments. The goal was to see if it could reduce severe asthma attacks over a year. However, the study was terminated early, so …

This phase 3 study tested an inhaled form of the antibiotic clofazimine added to standard therapy for people with MAC lung disease that did not respond to previous treatment. The goal was to see if the drug could clear the infection from sputum cultures and improve quality of lif…

This early-phase trial tested an inhaled drug called ARO-MUC5AC in healthy volunteers and people with asthma or COPD. The goal was to see if it is safe and how it affects lung function by targeting mucus production. The study was terminated early, so we have less information than…

This study tested an experimental drug called QBW251 in 42 adults with bronchiectasis, a lung condition that causes mucus buildup and infections. The goal was to see if the drug could reduce bacteria in the lungs and improve symptoms like coughing and breathing. However, the stud…

This Phase 1 trial tested a single dose of briquilimab in 17 adults with mild-to-moderate allergic asthma to see if it was safe and could reduce asthma attacks triggered by allergens. The study was terminated early, meaning it did not continue as planned. The main goal was to che…

This study tested a French version of the CAPTURE tool, which uses a short questionnaire and a peak flow breath test, to find people with undiagnosed obstructive lung disease (like COPD). Over 1,000 adults aged 40 and older who had not been diagnosed with asthma or COPD took part…

This small study tested whether adding n-acetylcysteine (NAC) to albuterol could improve lung function and reduce mucus plugs in people with moderate-to-severe asthma. Only 4 participants were enrolled before the trial was terminated early. The crossover design gave each person t…

This study looked at whether a supervised exercise program is possible for people with advanced bronchial cancer or mesothelioma. The goal was to see if patients could complete at least 6 rehab sessions to help with weakness and poor quality of life caused by the disease and its …

This study looked at how a new chewable asthma tablet called fevipiprant works in children aged 6 to 12. The goal was to measure the drug's levels in the body and check for safety. Only 11 children took part before the study was stopped early.

This study aims to collect up to 10 years of electronic medical records and a one-time questionnaire from over 1,100 asthma and COPD patients who previously took part in the Salford Lung Study. The goal is to better understand how these lung diseases progress and how treatments w…

This study aimed to see if skipping a type of muscle relaxant during general anesthesia could lower the risk of serious lung complications in high-risk surgery patients. The trial was terminated early after enrolling only 3 participants, so no meaningful conclusions can be drawn.…

This study looked at whether a variation in the PDE4 gene influences how well children with persistent asthma respond to the common rescue inhaler salbutamol. Researchers measured lung function before and after giving the drug and compared results across different gene types. The…

This study aimed to track lung function in children born prematurely (before 37 weeks) aged 3 to 5 years, comparing them to full-term children. Researchers used breathing tests and samples to look for early signs of asthma and allergies. The study was terminated early, so results…

This study aimed to see if special CT scans could detect changes in bone density and bone marrow in people with asthma who take oral steroids. Only 2 people took part before the study was stopped early. The results are too limited to draw any conclusions.

This study aimed to uncover hidden causes of asthma attacks and how inhaled steroids work. Researchers planned to analyze sputum from 67 adults with severe asthma. However, the study was terminated early, so results are limited.

This study is for people with cystic fibrosis and their family members. Its goal is to collect medical information and biological samples during regular clinic visits. These will be stored and used by researchers to learn more about how cystic fibrosis affects the body and how it…

This study looked at whether proteins that control our body's daily rhythms (clock proteins) can predict how severe asthma will get. Researchers monitored these proteins in the blood and sputum of 50 adults with severe eosinophilic asthma before and during treatment with mepolizu…

This study looked at adults with severe uncontrolled asthma in Germany to see how well their asthma was controlled over 12 months. Researchers used a simple questionnaire called AIRQ® to track symptoms, medication use, and doctor visits. The goal was to gather real-world informat…