Lung infection drug cayston fails to prove benefit in bronchiectasis trial

NCT ID NCT03696290

First seen Jan 12, 2026 · Last updated May 13, 2026 · Updated 19 times

Summary

This study tested the drug Cayston (aztreonam lysine) in adults with bronchiectasis, a chronic lung disease causing cough and frequent infections. The goal was to see if the drug could safely delay the next lung infection. The trial was stopped early after enrolling only 34 of the planned 100 participants, so results are limited.

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Contacts and locations

Locations

  • Aintree University Hospital

    Liverpool, United Kingdom

  • Cardiff & Vale University Local Health Board

    Cardiff, CF14 4HH, United Kingdom

  • Freeman Hospital

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Liverpool Heart and Chest Hospital

    Liverpool, L14 3PE, United Kingdom

  • Manchester University NHS Foundation Trust - Wythenshawe Hospital

    Manchester, M13 9WL, United Kingdom

  • NHS Lanakrshire University Hospital Hairmyres

    East Kilbride, G75 8RG, United Kingdom

  • NHS Lanarkshire: University Hospital Wishaw

    Wishaw, ML2 0DP, United Kingdom

  • NHS Tayside

    Dundee, DD1 9SY, United Kingdom

  • Royal Brompton & Harefield NHS Foundation Trust

    London, United Kingdom

  • Royal Papworth hospital NHS Foundation Trust

    Cambridge, CB2 0AY, United Kingdom

  • The Princess Alexandra Hospital NHS Trust

    Harlow, United Kingdom

  • Torbay Hospital

    Torquay, Devon, TQ2 7AA, United Kingdom

  • University Hospitals of Derby and Burton NHS Foundation Trust

    Derby, United Kingdom

  • University hospital Southampton NHS Foundation Trust

    Southampton, SO16 6YD, United Kingdom

Conditions

Explore the condition pages connected to this study.