Bronchiectasis drug trial halted early – what we know

NCT ID NCT03696290

Terminated Disease control Sponsor: University of Dundee Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tested the drug Cayston (aztreonam lysine) in adults with bronchiectasis, a chronic lung disease causing cough and infections. The goal was to see if it could safely delay or reduce lung flare-ups. However, the study was stopped early and only enrolled 34 people, so we have limited information on its benefits or risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aztreonam lysine (Cayston)
What this could lead to: If it works, this could point toward a treatment to reduce lung infections and hospital visits for people with bronchiectasis.
What could go wrong: The trial was terminated early with only 34 participants, so results are limited. It is unclear if the drug is effective or safe for this condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BRONCHIECTASIS ADULT are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

bronchiectasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHIECTASIS ADULT

Contacts and locations

Locations

Aintree University Hospital

Liverpool, United Kingdom
Cardiff & Vale University Local Health Board

Cardiff, CF14 4HH, United Kingdom
Freeman Hospital

Newcastle upon Tyne, NE7 7DN, United Kingdom
Liverpool Heart and Chest Hospital

Liverpool, L14 3PE, United Kingdom
Manchester University NHS Foundation Trust - Wythenshawe Hospital

Manchester, M13 9WL, United Kingdom
NHS Lanakrshire University Hospital Hairmyres

East Kilbride, G75 8RG, United Kingdom
NHS Lanarkshire: University Hospital Wishaw

Wishaw, ML2 0DP, United Kingdom
NHS Tayside

Dundee, DD1 9SY, United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

London, United Kingdom
Royal Papworth hospital NHS Foundation Trust

Cambridge, CB2 0AY, United Kingdom
The Princess Alexandra Hospital NHS Trust

Harlow, United Kingdom
Torbay Hospital

Torquay, Devon, TQ2 7AA, United Kingdom
University Hospitals of Derby and Burton NHS Foundation Trust

Derby, United Kingdom
University hospital Southampton NHS Foundation Trust

Southampton, SO16 6YD, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.