Drug trial aims to shrink nasal polyps without surgery

NCT ID NCT04157335

Terminated Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study tested whether regular injections of benralizumab could reduce nasal polyps and improve breathing in adults with severe nasal polyps and asthma. About 295 participants received either the drug or a placebo injection every few weeks for a year. The trial was terminated early, and results were measured by changes in polyp size, breathing symptoms, and quality of life.

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Contacts and locations

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Locations

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Huntington Beach, California, 92647, United States
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Grand Junction, Colorado, 81501, United States
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Gainesville, Florida, 32605, United States
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Louisville, Kentucky, 40220, United States
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White Marsh, Maryland, 21162, United States
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The Bronx, New York, 10461, United States
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White Plains, New York, 10605, United States
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Tulsa, Oklahoma, 74136, United States
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Bethlehem, Pennsylvania, 18017, United States
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Fort Worth, Texas, 76109, United States
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McKinney, Texas, 75070, United States
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St. George, Utah, 84790, United States
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Richmond, Virginia, 23235, United States
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Bellingham, Washington, 98225, United States
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Milwaukee, Wisconsin, 53228, United States
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Buenos Aires, C1121 ABE, Argentina
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Buenos Aires, C1414AIF, Argentina
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Ciudad de Buenos Aire, C1425BEN, Argentina
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San Fernando, B1646EBJ, Argentina
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Herston, 4029, Australia
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Melbourne, 3004, Australia
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Spearwood, 6163, Australia
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Plovdiv, 4001, Bulgaria
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Sofia, 1303, Bulgaria
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Sofia, 1606, Bulgaria
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Quillota, 2260000, Chile
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Santiago, 7500588, Chile
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Santiago, 8150000, Chile
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Talca, 3481349, Chile
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Beijing, 100044, China
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Beijing, 100191, China
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Beijing, 100730, China
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Changchun, 130061, China
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Changsha, 410008, China
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Changsha, 410013, China
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Changsha, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chongqing, 400042, China
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Foshan, 528000, China
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Guangzhou, 510000, China
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Guangzhou, 510180, China
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Hangzhou, 310003, China
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Jinan, 250014, China
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Nanchang, 330006, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Qingdao, 266071, China
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Shanghai, 200065, China
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Shanghai, 200092, China
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Tianjin, 300050, China
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Ürümqi, 830054, China
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Wuhan, 430022, China
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Xi'an, 710004, China
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Xi'an, 710061, China
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Yantai, 264000, China
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Marseille, 13005, France
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Toulouse, 31059, France
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Budapest, 1033, Hungary
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Budapest, 1046, Hungary
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Győr, 9024, Hungary
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Kaposvár, 7400, Hungary
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Siófok, 8600, Hungary
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Székesfehérvár, 8000, Hungary
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Tatabánya, 2800, Hungary
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Catanzaro, 88100, Italy
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Pisa, 56124, Italy
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Roma, 00161, Italy
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Roma, 00168, Italy
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Chiba, 262-0015, Japan
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Fujisawa-shi, 251-0052, Japan
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Hiroshima, 734-8551, Japan
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Ichikawa-shi, 272-0143, Japan
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Iida-shi, 395-8505, Japan
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Kawasaki-shi, 211-0063, Japan
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Kumamoto, 860-0814, Japan
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Meguro-ku, 153-0061, Japan
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Meguro-ku, 153-8515, Japan
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Minatoku, 105-8471, Japan
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Moriguchi-shi, 570-0074, Japan
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Nagaoka-shi, 940-2085, Japan
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Osaka, 540-0008, Japan
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Shinjuku-ku, 160-0017, Japan
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Yoshida-gun, 910-1193, Japan
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Bydgoszcz, 85-231, Poland
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Elblag, 82-300, Poland
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Krakow, 31-513, Poland
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Lublin, 20-552, Poland
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Nadarzyn, 05-830, Poland
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Poznan, 60-805, Poland
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Wroclaw, 53-301, Poland
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Łodź, 90-153, Poland
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Izhevsk, 426061, Russia
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Penza, 440067, Russia
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Saint Petersburg, 196158, Russia
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 114, Taiwan
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Taipei, 235, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Khon Kaen, 40002, Thailand
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Phitsanulok, 65000, Thailand
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Aydin, 09100, Turkey (Türkiye)
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Bakırköy, 34147, Turkey (Türkiye)
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Izmir, 35340, Turkey (Türkiye)
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Malatya, 44280, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam

Conditions

Explore the condition pages connected to this study.

EOSINOPHILIC CHRONIC RHINOSINUSITIS NASAL POLYPOSIS