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Asthma drug tested for stubborn nasal polyps – trial cut short

NCT ID NCT04157335

Terminated Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tested the drug benralizumab in 295 adults with severe nasal polyps and eosinophilic chronic sinusitis. Participants received injections of benralizumab or a placebo every 4 to 8 weeks for about a year. The goal was to see if the drug could shrink polyps and improve nasal blockage and sense of smell. The trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Benralizumab (a biologic drug given as an injection)

What this could lead to

If successful, this could point toward a new treatment option for people with severe nasal polyps and chronic sinusitis.

What could go wrong

The trial was terminated early, so results are limited. Benralizumab is already approved for asthma, but its effect on nasal polyps is still uncertain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

asthma nasal cavity polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EOSINOPHILIC CHRONIC RHINOSINUSITIS NASAL POLYPOSIS

Contacts and locations

Locations

  • Research Site

    Huntington Beach, California, 92647, United States

  • Research Site

    Grand Junction, Colorado, 81501, United States

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    Gainesville, Florida, 32605, United States

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    Louisville, Kentucky, 40220, United States

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    White Marsh, Maryland, 21162, United States

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    The Bronx, New York, 10461, United States

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    White Plains, New York, 10605, United States

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    Tulsa, Oklahoma, 74136, United States

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    Bethlehem, Pennsylvania, 18017, United States

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    Fort Worth, Texas, 76109, United States

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    McKinney, Texas, 75070, United States

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    St. George, Utah, 84790, United States

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    Richmond, Virginia, 23235, United States

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    Bellingham, Washington, 98225, United States

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    Milwaukee, Wisconsin, 53228, United States

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    Buenos Aires, C1121 ABE, Argentina

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    Buenos Aires, C1414AIF, Argentina

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    Ciudad de Buenos Aire, C1425BEN, Argentina

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    San Fernando, B1646EBJ, Argentina

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    Herston, 4029, Australia

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    Melbourne, 3004, Australia

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    Spearwood, 6163, Australia

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    Brussels, 1200, Belgium

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    Ghent, 9000, Belgium

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    Leuven, 3000, Belgium

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    Plovdiv, 4001, Bulgaria

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    Sofia, 1303, Bulgaria

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    Sofia, 1606, Bulgaria

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    Quillota, 2260000, Chile

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    Santiago, 7500588, Chile

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    Santiago, 8150000, Chile

  • Research Site

    Talca, 3481349, Chile

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    Beijing, 100044, China

  • Research Site

    Beijing, 100191, China

  • Research Site

    Beijing, 100730, China

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    Changchun, 130061, China

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    Changsha, 410008, China

  • Research Site

    Changsha, 410013, China

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    Changsha, China

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    Chengdu, 610041, China

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    Chengdu, 610072, China

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    Chongqing, 400042, China

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    Foshan, 528000, China

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    Guangzhou, 510000, China

  • Research Site

    Guangzhou, 510180, China

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    Hangzhou, 310003, China

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    Jinan, 250014, China

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    Nanchang, 330006, China

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    Nanjing, 210029, China

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    Nanning, 530021, China

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    Qingdao, 266071, China

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    Shanghai, 200065, China

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    Shanghai, 200092, China

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    Tianjin, 300050, China

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    Ürümqi, 830054, China

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    Wuhan, 430022, China

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    Xi'an, 710004, China

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    Xi'an, 710061, China

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    Yantai, 264000, China

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    Marseille, 13005, France

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    Toulouse, 31059, France

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    Budapest, 1033, Hungary

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    Budapest, 1046, Hungary

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    Győr, 9024, Hungary

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    Kaposvár, 7400, Hungary

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    Siófok, 8600, Hungary

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    Székesfehérvár, 8000, Hungary

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    Tatabánya, 2800, Hungary

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    Catanzaro, 88100, Italy

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    Pisa, 56124, Italy

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    Roma, 00161, Italy

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    Roma, 00168, Italy

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    Chiba, 262-0015, Japan

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    Fujisawa-shi, 251-0052, Japan

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    Hiroshima, 734-8551, Japan

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    Ichikawa-shi, 272-0143, Japan

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    Iida-shi, 395-8505, Japan

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    Kawasaki-shi, 211-0063, Japan

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    Kumamoto, 860-0814, Japan

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    Meguro-ku, 153-0061, Japan

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    Meguro-ku, 153-8515, Japan

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    Minatoku, 105-8471, Japan

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    Moriguchi-shi, 570-0074, Japan

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    Nagaoka-shi, 940-2085, Japan

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    Osaka, 540-0008, Japan

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    Shinjuku-ku, 160-0017, Japan

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    Yoshida-gun, 910-1193, Japan

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    Bydgoszcz, 85-231, Poland

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    Elblag, 82-300, Poland

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    Krakow, 31-513, Poland

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    Lublin, 20-552, Poland

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    Nadarzyn, 05-830, Poland

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    Poznan, 60-805, Poland

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    Wroclaw, 53-301, Poland

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    Łodź, 90-153, Poland

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    Izhevsk, 426061, Russia

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    Penza, 440067, Russia

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    Saint Petersburg, 196158, Russia

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    Taipei, 10002, Taiwan

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    Taipei, 110, Taiwan

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    Taipei, 11217, Taiwan

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    Taipei, 114, Taiwan

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    Taipei, 235, Taiwan

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    Taoyuan, 333, Taiwan

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    Bangkok, 10330, Thailand

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    Bangkok, 10400, Thailand

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    Bangkok, 10700, Thailand

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    Chiang Mai, 50200, Thailand

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    Khon Kaen, 40002, Thailand

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    Phitsanulok, 65000, Thailand

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    Aydin, 09100, Turkey (Türkiye)

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    Bakırköy, 34147, Turkey (Türkiye)

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    Izmir, 35340, Turkey (Türkiye)

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    Malatya, 44280, Turkey (Türkiye)

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    Hanoi, 100000, Vietnam

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    Ho Chi Minh City, 700000, Vietnam