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T2-low asthma

MONDO:0956976

A chronic asthma that is characterized by the pathophysiology phenotype combination (endotype) of non-atopic, smoking, obesity related, and elderly and that is characterized by neutrophilic (sputum neutrophils > 40–60%) or paucigranulocytic (i.e., normal sputum levels of both eosinophils and neutrophils) inflammation and a lack of response to corticosteroid therapy.

1 clinical trial for this condition and its sub-types.

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Broader categories

Asthma (683) Disease (680) Respiratory system disorder (137) Chronic asthma (109) Bronchial disorder (18) Lower respiratory tract disorder (17) Human disease (14) Disease by body system or component (0)
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  • Could a Mucus-Busting drug help Hard-to-Treat asthma?

    Symptom relief Completed

    This small pilot study tested whether inhaling a drug called rhDNAse every day for 4 weeks could help adults with neutrophilic asthma, a type of asthma that often doesn't respond well to standard treatments. The drug works by breaking down DNA in lung mucus, making it thinner and…

    Phase: PHASE1, PHASE2 • Sponsor: National Jewish Health • Aim: Symptom relief

    Last updated Jun 27, 2026 12:09 UTC

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