Could a Mucus-Busting drug help Hard-to-Treat asthma?
NCT ID NCT03994380
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small pilot study tested whether inhaling a drug called rhDNAse every day for 4 weeks could help adults with neutrophilic asthma, a type of asthma that often doesn't respond well to standard treatments. The drug works by breaking down DNA in lung mucus, making it thinner and easier to cough up. Researchers measured changes in lung function and asthma symptom control to see if the treatment was beneficial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rhDNAse (a drug that breaks down DNA in mucus, making it easier to clear from the lungs)
What this could lead to
If it works, this could point toward a new way to ease breathing and control symptoms for people with neutrophilic asthma.
What could go wrong
This is a very small, early-phase pilot study with only 19 participants, so results may not apply to everyone. The drug may not improve lung function or symptoms as hoped.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Jewish Health
Denver, Colorado, 80206, United States