Could a severe asthma drug also ease hayfever symptoms?
NCT ID NCT06189742
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether tezepelumab, a drug already approved for severe asthma, can also reduce nasal symptoms caused by hayfever in people who have both allergic asthma and allergic rhinitis. Nineteen participants will receive monthly injections of tezepelumab for 12 months, and their nasal symptoms and allergic markers will be measured after exposure to allergens. The study also includes a small group of non-allergic participants for comparison.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tezepelumab (a monoclonal antibody that blocks a protein involved in allergic inflammation)
- What this could lead to
- If it works, this could point toward a new treatment option for people with both allergic asthma and hayfever, reducing nasal symptoms after allergen exposure.
- What could go wrong
- This is a very small pilot study with only 19 participants, so results may not apply to everyone. It is also open-label, meaning both participants and researchers know who gets the drug, which can bias results.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kingston Health Sciences Centre- Kingston General Hospital
Kingston, Ontario, K7L 2V7, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can an antihistamine–steroid combo pill beat standard allergy meds?
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- Allergy study seeks to pinpoint those most bothered by cats and birch pollen
- Allergy shots may unlock better asthma control by targeting hidden immune signals