New asthma drug could help patients ditch their daily inhalers

NCT ID NCT06473779

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug tezepelumab can help people with severe asthma reduce their daily maintenance inhaler dose without losing control of their asthma. About 326 adolescents and adults will receive tezepelumab injections and then try to step down their usual inhaler therapy. The goal is to see if they can maintain asthma control with less medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tezepelumab (injection)
What this could lead to: If successful, this could show that tezepelumab helps people with severe asthma use less daily medication while still keeping their asthma under control.
What could go wrong: This is a phase 3 trial, but results may not apply to everyone. Reducing medication could still lead to asthma flare-ups in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE ASTHMA

Contacts and locations

Locations

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Palmdale, California, 93551, United States
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Colorado Springs, Colorado, 80907, United States
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Miami, Florida, 33136, United States
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Boston, Massachusetts, 02115, United States
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St Louis, Missouri, 63110, United States
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New Brunswick, New Jersey, 08901, United States
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Oklahoma City, Oklahoma, 73120, United States
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McAllen, Texas, 78503, United States
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Berazategui, 1104, Argentina
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CABA, C1012AAR, Argentina
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Concepción del Uruguay, 3260, Argentina
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Mendoza, 5500, Argentina
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Mendoza, M5500CCG, Argentina
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Quilmes, B1878FNR, Argentina
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Rosario, 2000, Argentina
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Rosario, 2002, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Santa Fe, 3000, Argentina
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Anderlecht, 1070, Belgium
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Edegem, 2650, Belgium
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Erpent, 5101, Belgium
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Ghent, 9000, Belgium
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Liège, 4000, Belgium
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Haskovo, 6300, Bulgaria
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Pleven, 5804, Bulgaria
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Razgrad, 7200, Bulgaria
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Rousse, 7002, Bulgaria
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Sofia, 1154, Bulgaria
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Sofia, 1431, Bulgaria
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Stara Zagora, 6003, Bulgaria
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Velika Tarnovo, 5250, Bulgaria
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Vancouver, British Columbia, V5Z 1M9, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Windsor, Ontario, N8X 1T3, Canada
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Québec, Quebec, G1V 4G5, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Regina, Saskatchewan, S7N 5A2, Canada
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Aalborg, 9000, Denmark
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Hvidovre, 2650, Denmark
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Svendborg, 5700, Denmark
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Vejle, 7100, Denmark
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Créteil, 94000, France
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La Tronche, 38700, France
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Lyon, 69004, France
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Marseille, 13915, France
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Montpellier, 34295, France
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Strasbourg, 67091, France
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Augsburg, 86150, Germany
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Bonn, 53127, Germany
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Cottbus, 03050, Germany
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Hanover, 30625, Germany
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Mainz, 55128, Germany
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Florence, 50134, Italy
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Orbassano, 10043, Italy
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Roma, 00161, Italy
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Roma, 00168, Italy
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Verona, 37134, Italy
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Chihuahua City, 31200, Mexico
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Cuauhtémoc, 06700, Mexico
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Monterrey, 64360, Mexico
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Badalona(Barcelona), 08916, Spain
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Barcelona, 08035, Spain
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Lugo, 27002, Spain
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Madrid, 28006, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Belfast, BT9 7BL, United Kingdom
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Liverpool, L7 8XP, United Kingdom
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London, SE1 9RT, United Kingdom
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Southampton, SO16 6YD, United Kingdom

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