Hope for severe asthma: study tests if biologics can heal lungs

NCT ID NCT07174713

Not yet recruiting Knowledge-focused Sponsor: Western University, Canada Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study looks at whether biologic therapy can reverse long-term lung damage in adults with severe asthma. Researchers will follow 150 patients and 50 healthy volunteers for two years, using advanced imaging and lung function tests. The goal is to see if treatment leads to 'clinical remission' and if the lungs can heal at the airway and blood vessel level.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Biologic therapy (a type of drug that blocks specific inflammation pathways in asthma)
What this could lead to: If successful, this could show that biologic therapy not only controls symptoms but may reverse some lung damage in adults with severe asthma, pointing toward a deeper remission.
What could go wrong: This is an observational study, not a treatment trial, so it won't prove the therapy works. Results may vary by age and asthma duration, and the study is still recruiting.

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Conditions

The condition(s) this trial relates to.

Airway Remodeling allergic asthma chronic asthma pulmonary eosinophilia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA; EOSINOPHILIC

Contacts and locations

Locations

Robarts Research Institute; The University of Western Ontario

London, Ontario, N6A 5B7, Canada

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