Could antidepressants finally silence chronic cough?
NCT ID NCT05110144
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether two common antidepressants, duloxetine and amitriptyline, can reduce coughing in people with refractory chronic cough—a cough that persists despite standard treatments. About 50 adults will receive either a low or high dose of one drug or a placebo for 4 weeks. Researchers will measure cough frequency using a special monitor to see if these drugs offer relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
duloxetine and amitriptyline
What this could lead to
If it works, this could point toward a new treatment option for people with chronic cough that doesn't respond to other therapies.
What could go wrong
This is an early phase 2 trial with only 50 people, so results may not apply to everyone. The drugs can cause side effects like drowsiness, dry mouth, or nausea.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact
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