Could antidepressants finally silence chronic cough?
NCT ID NCT05110144
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether two common antidepressants, duloxetine and amitriptyline, can reduce coughing in people with refractory chronic cough—a cough that persists despite standard treatments. About 50 adults will receive either a low or high dose of one drug or a placebo for 4 weeks. Researchers will measure cough frequency using a special monitor to see if these drugs offer relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- duloxetine and amitriptyline
- What this could lead to
- If it works, this could point toward a new treatment option for people with chronic cough that doesn't respond to other therapies.
- What could go wrong
- This is an early phase 2 trial with only 50 people, so results may not apply to everyone. The drugs can cause side effects like drowsiness, dry mouth, or nausea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for REFRACTORY CHRONIC COUGH are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New pill aims to silence chronic cough that Won't quit
- New pill aims to silence stubborn chronic cough
- New hope for chronic coughers: experimental drug enters final testing phase
- Can cough training and a natural inhaler silence chronic cough?
- New database aims to unravel mysteries of chronic cough
- New cough pill shows promise in clinical trial