New pill aims to silence stubborn chronic cough
NCT ID NCT07671924
First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 3 times
Summary
This study tests a new extended-release tablet called nalbuphine for people with refractory chronic cough—a cough that persists despite treatment. About 100 adults will receive either the drug or a placebo for 6 weeks. The main goal is to see if the drug reduces how often people cough over 24 hours.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nalbuphine extended-release tablets
- What this could lead to
- If successful, this could provide a new treatment option for people with chronic cough that doesn't respond to other therapies.
- What could go wrong
- This is an early Phase 2 trial with only 100 participants, so results may not be conclusive. The drug may not reduce cough better than placebo, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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BLC Clinical Research
RECRUITINGBurlington, L7N3V2, Canada
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Centre D'Investigation Clinique Mauricie Inc (CIC Mauricie)
RECRUITINGTrois-Rivières, G8T7A1, Canada
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Clinique Specialisee En Allergie De La Capitale
RECRUITINGQuébec, G1V4W2, Canada
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Clinque DE Pneumologie ET Du Sommeil DE Lanaudiere
RECRUITINGSaint-Charles-Borromée, J6E 2B4, Canada
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Diex Recherche - Quebec
RECRUITINGQuébec, G1V4T3, Canada
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Diex Recherche-Victoriaville
RECRUITINGVictoriaville, G6P3Z8, Canada
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Dynamic Drug Advancement Ltd
RECRUITINGAjax, L1S 2J5, Canada
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Fadia El Boreky Medicine Prof. Corp.
RECRUITINGWaterloo, N2J1C4, Canada
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Medical Arts Health Research Group - North Vancouver
RECRUITINGNorth Van Couver, V7P2T4, Canada
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Recherche GCP Research
RECRUITINGMontreal, H1Y3H5, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New pill aims to silence chronic cough that Won't quit
- New hope for chronic coughers: experimental drug enters final testing phase
- Can cough training and a natural inhaler silence chronic cough?
- New database aims to unravel mysteries of chronic cough
- New cough pill shows promise in clinical trial
- New pill aims to silence stubborn coughs