Can cough training and a natural inhaler silence chronic cough?

NCT ID NCT06960759

Recruiting now Symptom relief Sponsor: University of Montana Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This study tests two treatments for people with chronic cough that hasn't improved with usual care. One treatment teaches techniques to control coughing, and the other adds an inhaled natural substance meant to reduce cough sensitivity. Researchers will measure how well participants can suppress coughs, how their brain responds, and whether their quality of life improves. The trial involves 135 adults and includes a no-treatment control group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: behavioral cough suppression therapy and an inhaled natural substance (capsaicin) to desensitize sensory nerves
What this could lead to: If successful, this could point toward a new, non-drug treatment option for people with chronic cough that hasn't responded to standard therapies.
What could go wrong: This is an early phase 2 trial with only 135 participants, so results may not apply to everyone. The natural substance is inhaled and may cause irritation or not work better than the behavioral therapy alone.

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Conditions

The condition(s) this trial relates to.

Chronic Cough cough hypersensitivity syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC COUGH (CC) REFRACTORY CHRONIC COUGH UNEXPLAINED CHRONIC COUGH

Contacts and locations

Locations

Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
University of Colorado Anschutz Medical Campus
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States
University of Montana
RECRUITING

Missoula, Montana, 59812, United States

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