Radioactive drug takes on standard therapy in lung cancer trial
NCT ID NCT04665739
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase II trial tests whether a radioactive drug called lutetium Lu 177 dotatate works better than the usual drug everolimus for people with advanced bronchial neuroendocrine tumors (a type of lung cancer). The radioactive drug targets a protein on tumor cells and delivers radiation to kill them. About 70 participants will be randomly assigned to one of the two treatments, and researchers will compare how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lutetium Lu 177 dotatate (a radioactive drug that targets tumor cells) and everolimus (a standard drug)
What this could lead to
If successful, this could offer a more effective treatment option for people with advanced bronchial neuroendocrine tumors, potentially slowing tumor growth better than current therapy.
What could go wrong
This is a phase II trial with only 70 participants, so results are preliminary. The radioactive drug may cause side effects like kidney or bone marrow damage, and it may not prove superior to everolimus.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Case Western Reserve University
RECRUITINGCleveland, Ohio, 44106, United States
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Fox Chase Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
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Huntsman Cancer Institute/University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Iowa Methodist Medical Center
RECRUITINGDes Moines, Iowa, 50309, United States
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Loma Linda University Medical Center
RECRUITINGLoma Linda, California, 92354, United States
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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MedStar Georgetown University Hospital
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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Missouri Baptist Medical Center
RECRUITINGSt Louis, Missouri, 63131, United States
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Ohio State University Comprehensive Cancer Center
SUSPENDEDColumbus, Ohio, 43210, United States
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Temple University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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Torrance Memorial Physician Network - Cancer Care
RECRUITINGTorrance, California, 90505, United States
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Tower Cancer Research Foundation
RECRUITINGBeverly Hills, California, 90211, United States
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UC Comprehensive Cancer Center at Silver Cross
RECRUITINGNew Lenox, Illinois, 60451, United States
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UCSF Medical Center-Mission Bay
RECRUITINGSan Francisco, California, 94158, United States
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITINGAnkeny, Iowa, 50023, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITINGDes Moines, Iowa, 50309, United States
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UM Sylvester Comprehensive Cancer Center at Aventura
SUSPENDEDAventura, Florida, 33180, United States
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UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITINGCoral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITINGDeerfield Beach, Florida, 33442, United States
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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITINGPlantation, Florida, 33324, United States
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University of Alabama at Birmingham Cancer Center
WITHDRAWNBirmingham, Alabama, 35233, United States
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University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Chicago Medicine-Orland Park
RECRUITINGOrland Park, Illinois, 60462, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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Vanderbilt University/Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37232, United States
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