Radioactive drug takes on standard therapy in lung cancer trial

NCT ID NCT04665739

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 13 times

Summary

This phase II trial tests whether a radioactive drug called lutetium Lu 177 dotatate works better than the usual drug everolimus for people with advanced bronchial neuroendocrine tumors (a type of lung cancer). The radioactive drug targets a protein on tumor cells and delivers radiation to kill them. About 70 participants will be randomly assigned to one of the two treatments, and researchers will compare how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lutetium Lu 177 dotatate (a radioactive drug that targets tumor cells) and everolimus (a standard drug)
What this could lead to: If successful, this could offer a more effective treatment option for people with advanced bronchial neuroendocrine tumors, potentially slowing tumor growth better than current therapy.
What could go wrong: This is a phase II trial with only 70 participants, so results are preliminary. The radioactive drug may cause side effects like kidney or bone marrow damage, and it may not prove superior to everolimus.

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Conditions

The condition(s) this trial relates to.

bronchial endocrine tumor lung neuroendocrine neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED LUNG NEUROENDOCRINE TUMOR FUNCTIONING LUNG NEUROENDOCRINE TUMOR LOCALLY ADVANCED LUNG NEUROENDOCRINE NEOPLASM LUNG NEUROENDOCRINE NEOPLASM LUNG NEUROENDOCRINE TUMOR G1 LUNG NEUROENDOCRINE TUMOR G2 METASTATIC LUNG NEUROENDOCRINE NEOPLASM METASTATIC LUNG NEUROENDOCRINE TUMOR NON-FUNCTIONING LUNG NEUROENDOCRINE TUMOR RECURRENT LUNG NEUROENDOCRINE NEOPLASM UNRESECTABLE LUNG NEUROENDOCRINE NEOPLASM UNRESECTABLE LUNG NEUROENDOCRINE TUMOR

Contacts and locations

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Locations

Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

Contact Email: •••••@•••••
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Medical Center
SUSPENDED

Durham, North Carolina, 27710, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Loma Linda University Medical Center
SUSPENDED

Loma Linda, California, 92354, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Georgetown University Hospital
SUSPENDED

Washington D.C., District of Columbia, 20007, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Ohio State University Comprehensive Cancer Center
SUSPENDED

Columbus, Ohio, 43210, United States
Temple University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
Torrance Memorial Physician Network - Cancer Care
RECRUITING

Torrance, California, 90505, United States
Tower Cancer Research Foundation
RECRUITING

Beverly Hills, California, 90211, United States

Contact Email: •••••@•••••
UC Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States

Contact Email: •••••@•••••
UCSF Medical Center-Mission Bay
SUSPENDED

San Francisco, California, 94158, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UM Sylvester Comprehensive Cancer Center at Aventura
SUSPENDED

Aventura, Florida, 33180, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Alabama at Birmingham Cancer Center
WITHDRAWN

Birmingham, Alabama, 35233, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

Contact Email: •••••@•••••
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States

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